FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012839084> ?p ?o ?g. }

• W2012839084 endingPage "359" @default.
• W2012839084 startingPage "353" @default.
• W2012839084 abstract "Patients suffering from chronic renal failure (CRF) are exposed to increased oxidative stress generated by uremic toxins, factors connected with hemodialysis, chronic inflammatory state, lack of vitamins A, E and selenium, advanced age, and parenteral iron administration. Their antioxidative system is inefficient. In erythrocytes, hexosemonophosphate (HMP) cycle does not assure an adequate amount of reductive equivalents (NADPH) necessary to restore reduced glutathione (GSH), an important free radical scavenger. Hemodialysis treatment also causes a large loss of glucose, which is the basic substrate for that metabolic pathway. The object of the research was to establish the influence of glucose present in dialysate on antioxidant defense system in red blood cells.A group of 51 patients undergoing regular hemodialysis using glucose (26 subjects, GL+ HD) or non-glucose fluid (25 subjects, GL- HD) was studied. The GSH concentration, glucose-6-phosphate dehydrogenase (G-6-P DH) and glutathione reductase (GSSG-R) activities were determined. Glucose concentration before and after the hemodialysis session was also measured.The activity of G-6-P DH was significantly higher in GL+ HD both before (p = 0.000) and after (p = 0.0002) the dialysis treatment compared to GL- HD, respectively, and to the healthy subjects (p = 0.000). The hemodialysis session caused a decrease in the activity of the enzyme in GL+ HD from 4.91 +/- 1.53 to 4.42 +/- 1.40 U/g Hb (p = 0.004) as well as in GL- HD from 3.97 +/- 1.00 to 3.59 +/- 0.87 U/g Hb (p = 0.007). The GSSG-R showed an increase in activity in CRF patients before HD (in GL+ HD to 2.57 +/- 0.76 and in GL- HD to 2.82 +/- 0.98 U/gHb). After dialysis, lower values were observed, particularly in GL+ HD (2.05 +/- 0.59 U/g Hb, p = 0.004). GSH concentrations in the examined group were higher (in GL+ HD 0.0205 +/- 0.008 and in GL- HD 0.0196 +/- 0.008 mmol/g Hb) than in controlled subjects (0.0142 +/- 0.002 mmol/g Hb) and decreased during dialysis treatment (considerably only in GL- HD to 0.0183 +/- 0.007 mmol/g Hb, p = 0.056). Glucose concentrations in GL+ HD were significantly higher compared to GL- HD (p < 0.002).Glucose presence in dialyzing fluid improves the HMP cycle activity as well as glutathione system reactions and determines a better antioxidant status of erythrocytes. It limits hemolysis and improves the hematological parameters in CRF." @default.
• W2012839084 created "2016-06-24" @default.
• W2012839084 creator A5013028311 @default.
• W2012839084 creator A5028880122 @default.
• W2012839084 creator A5054955592 @default.
• W2012839084 creator A5055264509 @default.
• W2012839084 creator A5076325081 @default.
• W2012839084 creator A5088366789 @default.
• W2012839084 date "2006-04-01" @default.
• W2012839084 modified "2023-10-14" @default.
• W2012839084 title "Erythrocyte Antioxidant Defense System in Patients with Chronic Renal Failure According to the Hemodialysis Conditions" @default.
• W2012839084 cites W139318294 @default.
• W2012839084 cites W1738546326 @default.
• W2012839084 cites W1963753712 @default.
• W2012839084 cites W1982820468 @default.
• W2012839084 cites W1988755634 @default.
• W2012839084 cites W1992380078 @default.
• W2012839084 cites W2000725664 @default.
• W2012839084 cites W2014627151 @default.
• W2012839084 cites W2044935153 @default.
• W2012839084 cites W2074207584 @default.
• W2012839084 cites W2094343090 @default.
• W2012839084 cites W2133376251 @default.
• W2012839084 cites W2136128927 @default.
• W2012839084 cites W2136748937 @default.
• W2012839084 cites W2142260767 @default.
• W2012839084 cites W2150052162 @default.
• W2012839084 cites W2330220730 @default.
• W2012839084 doi "https://doi.org/10.1016/j.arcmed.2005.07.012" @default.
• W2012839084 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16513484" @default.
• W2012839084 hasPublicationYear "2006" @default.
• W2012839084 type Work @default.
• W2012839084 sameAs 2012839084 @default.
• W2012839084 citedByCount "21" @default.
• W2012839084 countsByYear W20128390842012 @default.
• W2012839084 countsByYear W20128390842013 @default.
• W2012839084 countsByYear W20128390842014 @default.
• W2012839084 countsByYear W20128390842015 @default.
• W2012839084 countsByYear W20128390842016 @default.
• W2012839084 countsByYear W20128390842018 @default.
• W2012839084 countsByYear W20128390842022 @default.
• W2012839084 crossrefType "journal-article" @default.
• W2012839084 hasAuthorship W2012839084A5013028311 @default.
• W2012839084 hasAuthorship W2012839084A5028880122 @default.
• W2012839084 hasAuthorship W2012839084A5054955592 @default.
• W2012839084 hasAuthorship W2012839084A5055264509 @default.
• W2012839084 hasAuthorship W2012839084A5076325081 @default.
• W2012839084 hasAuthorship W2012839084A5088366789 @default.
• W2012839084 hasConcept C126322002 @default.
• W2012839084 hasConcept C134018914 @default.
• W2012839084 hasConcept C165069038 @default.
• W2012839084 hasConcept C181199279 @default.
• W2012839084 hasConcept C185592680 @default.
• W2012839084 hasConcept C2776151105 @default.
• W2012839084 hasConcept C2778004101 @default.
• W2012839084 hasConcept C2778063415 @default.
• W2012839084 hasConcept C2778760513 @default.
• W2012839084 hasConcept C2778979269 @default.
• W2012839084 hasConcept C2779978075 @default.
• W2012839084 hasConcept C2993356106 @default.
• W2012839084 hasConcept C538909803 @default.
• W2012839084 hasConcept C55493867 @default.
• W2012839084 hasConcept C71924100 @default.
• W2012839084 hasConceptScore W2012839084C126322002 @default.
• W2012839084 hasConceptScore W2012839084C134018914 @default.
• W2012839084 hasConceptScore W2012839084C165069038 @default.
• W2012839084 hasConceptScore W2012839084C181199279 @default.
• W2012839084 hasConceptScore W2012839084C185592680 @default.
• W2012839084 hasConceptScore W2012839084C2776151105 @default.
• W2012839084 hasConceptScore W2012839084C2778004101 @default.
• W2012839084 hasConceptScore W2012839084C2778063415 @default.
• W2012839084 hasConceptScore W2012839084C2778760513 @default.
• W2012839084 hasConceptScore W2012839084C2778979269 @default.
• W2012839084 hasConceptScore W2012839084C2779978075 @default.
• W2012839084 hasConceptScore W2012839084C2993356106 @default.
• W2012839084 hasConceptScore W2012839084C538909803 @default.
• W2012839084 hasConceptScore W2012839084C55493867 @default.
• W2012839084 hasConceptScore W2012839084C71924100 @default.
• W2012839084 hasIssue "3" @default.
• W2012839084 hasLocation W20128390841 @default.
• W2012839084 hasLocation W20128390842 @default.
• W2012839084 hasOpenAccess W2012839084 @default.
• W2012839084 hasPrimaryLocation W20128390841 @default.
• W2012839084 hasRelatedWork W1989911237 @default.
• W2012839084 hasRelatedWork W1992181654 @default.
• W2012839084 hasRelatedWork W2077735452 @default.
• W2012839084 hasRelatedWork W2103558449 @default.
• W2012839084 hasRelatedWork W2410694141 @default.
• W2012839084 hasRelatedWork W2748952813 @default.
• W2012839084 hasRelatedWork W2793794267 @default.
• W2012839084 hasRelatedWork W2913678864 @default.
• W2012839084 hasRelatedWork W3082631906 @default.
• W2012839084 hasRelatedWork W4309491691 @default.
• W2012839084 hasVolume "37" @default.
• W2012839084 isParatext "false" @default.
• W2012839084 isRetracted "false" @default.
• W2012839084 magId "2012839084" @default.
• W2012839084 workType "article" @default.