FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012849499> ?p ?o ?g. }

• W2012849499 endingPage "636" @default.
• W2012849499 startingPage "630" @default.
• W2012849499 abstract "Intraperitoneal inoculation of rhesus rotavirus (RRV) was shown to cause atretic-appearing segments of the extrahepatic bile ducts (EHBDs) in a murine model. The factors responsible for the injury of bile ducts, however, remain unknown. In this study, the morphologic status of nuclear factor- kappa B (NF- kappa B) activation in the liver and in the EHBDs from murine model of biliary atresia induced by intraperitoneal injection of rotavirus was investigated.Within the first 24 hours of life, the newborn mice were infected through intraperitoneal route with a volume of 50 microL containing different titers of RRV. The pups were killed on days 5, 10, 15, 21, and 28 after inoculation and prepared under a dissecting microscope with photographic documentation. Consecutive sections of specimens were stained with H & E and used for histopathologic studies. The methods of modified Vision immunohistochemical staining was used to detect viral antigen of VP7 and active NF- kappa B. The distribution and intensity of staining were analyzed by image analysis software (GT-2 model, Huakang Co, Chengdu, China).The viral antigen was detected by immunohistochemical staining in specimens from experimental groups on day 5 after infection. The occlusion of the EHBDs could be visualized after intraperitoneal injection of 10(7) plaque-forming unit (pfu) of RRV, whereas the incidence of cholestasis was reduced with an infection dosage of 10(6) pfu or less. Obliteration of the EHBDs did not occur when the injection dosage of RRV was reduced to 10(5) pfu or when inoculation of 10(7) pfu of RRV was combined with pyrolidine dithiocarbamate (PDTC), a chemical inhibitor of active NF- kappa B. The antigen of active NF- kappa B was detected by immunohistochemical staining in the liver and in the EHBDs from pups after inoculation of 10(7), 10(6), and 10(5) pfu RRV. Low or no expression of active NF- kappa B was noted in the specimens obtained from the control group. As the inflammatory reaction in the liver and in the EHBDs gradually subsided on day 28 after inoculation, the expression of active NF- kappa B also decreased. The expression of active NF- kappa B after injection of RRV combined with PDTC was similar to the expression in the control group on days 5 and 10 after infection.The authors found that occlusion of the EHBDs could be noted in pups after inoculation of 10(7) pfu RRV. Meanwhile, the expression of active NF- kappa B in the liver and in the EHBDs was increased after inoculation of RRV. Simultaneous intraperitoneal injection of PDTC, however, was shown to prevent the obstruction of EHBDs secondary to inoculation of RRV. These results show that the murine biliary atresia induced by RRV is mediated by active NF- kappa B." @default.
• W2012849499 created "2016-06-24" @default.
• W2012849499 creator A5010103479 @default.
• W2012849499 creator A5017101632 @default.
• W2012849499 creator A5046908490 @default.
• W2012849499 creator A5051103878 @default.
• W2012849499 creator A5058775061 @default.
• W2012849499 date "2005-04-01" @default.
• W2012849499 modified "2023-09-24" @default.
• W2012849499 title "Rotavirus-induced murine biliary atresia is mediated by nuclear factor-κB" @default.
• W2012849499 cites W1480466711 @default.
• W2012849499 cites W1900911764 @default.
• W2012849499 cites W1966098811 @default.
• W2012849499 cites W1979256820 @default.
• W2012849499 cites W1984380214 @default.
• W2012849499 cites W2021012809 @default.
• W2012849499 cites W2025173334 @default.
• W2012849499 cites W2031375858 @default.
• W2012849499 cites W2051410178 @default.
• W2012849499 cites W2058289691 @default.
• W2012849499 cites W2064711537 @default.
• W2012849499 cites W2064776807 @default.
• W2012849499 cites W2068840478 @default.
• W2012849499 cites W2072072513 @default.
• W2012849499 cites W2074010058 @default.
• W2012849499 cites W2154781639 @default.
• W2012849499 cites W2164098641 @default.
• W2012849499 cites W2169294522 @default.
• W2012849499 cites W4241173789 @default.
• W2012849499 cites W4254439161 @default.
• W2012849499 doi "https://doi.org/10.1016/j.jpedsurg.2004.12.004" @default.
• W2012849499 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15852269" @default.
• W2012849499 hasPublicationYear "2005" @default.
• W2012849499 type Work @default.
• W2012849499 sameAs 2012849499 @default.
• W2012849499 citedByCount "25" @default.
• W2012849499 countsByYear W20128494992012 @default.
• W2012849499 countsByYear W20128494992013 @default.
• W2012849499 countsByYear W20128494992014 @default.
• W2012849499 countsByYear W20128494992015 @default.
• W2012849499 countsByYear W20128494992016 @default.
• W2012849499 countsByYear W20128494992018 @default.
• W2012849499 countsByYear W20128494992020 @default.
• W2012849499 countsByYear W20128494992022 @default.
• W2012849499 crossrefType "journal-article" @default.
• W2012849499 hasAuthorship W2012849499A5010103479 @default.
• W2012849499 hasAuthorship W2012849499A5017101632 @default.
• W2012849499 hasAuthorship W2012849499A5046908490 @default.
• W2012849499 hasAuthorship W2012849499A5051103878 @default.
• W2012849499 hasAuthorship W2012849499A5058775061 @default.
• W2012849499 hasConcept C126322002 @default.
• W2012849499 hasConcept C142724271 @default.
• W2012849499 hasConcept C159654299 @default.
• W2012849499 hasConcept C16685009 @default.
• W2012849499 hasConcept C203014093 @default.
• W2012849499 hasConcept C204232928 @default.
• W2012849499 hasConcept C2778593092 @default.
• W2012849499 hasConcept C2779243279 @default.
• W2012849499 hasConcept C2779609443 @default.
• W2012849499 hasConcept C2779802037 @default.
• W2012849499 hasConcept C2780159080 @default.
• W2012849499 hasConcept C2781367151 @default.
• W2012849499 hasConcept C2911091166 @default.
• W2012849499 hasConcept C32611913 @default.
• W2012849499 hasConcept C71924100 @default.
• W2012849499 hasConcept C74864618 @default.
• W2012849499 hasConceptScore W2012849499C126322002 @default.
• W2012849499 hasConceptScore W2012849499C142724271 @default.
• W2012849499 hasConceptScore W2012849499C159654299 @default.
• W2012849499 hasConceptScore W2012849499C16685009 @default.
• W2012849499 hasConceptScore W2012849499C203014093 @default.
• W2012849499 hasConceptScore W2012849499C204232928 @default.
• W2012849499 hasConceptScore W2012849499C2778593092 @default.
• W2012849499 hasConceptScore W2012849499C2779243279 @default.
• W2012849499 hasConceptScore W2012849499C2779609443 @default.
• W2012849499 hasConceptScore W2012849499C2779802037 @default.
• W2012849499 hasConceptScore W2012849499C2780159080 @default.
• W2012849499 hasConceptScore W2012849499C2781367151 @default.
• W2012849499 hasConceptScore W2012849499C2911091166 @default.
• W2012849499 hasConceptScore W2012849499C32611913 @default.
• W2012849499 hasConceptScore W2012849499C71924100 @default.
• W2012849499 hasConceptScore W2012849499C74864618 @default.
• W2012849499 hasIssue "4" @default.
• W2012849499 hasLocation W20128494991 @default.
• W2012849499 hasLocation W20128494992 @default.
• W2012849499 hasOpenAccess W2012849499 @default.
• W2012849499 hasPrimaryLocation W20128494991 @default.
• W2012849499 hasRelatedWork W1992481203 @default.
• W2012849499 hasRelatedWork W1993946980 @default.
• W2012849499 hasRelatedWork W2013745628 @default.
• W2012849499 hasRelatedWork W2015905852 @default.
• W2012849499 hasRelatedWork W2035464821 @default.
• W2012849499 hasRelatedWork W2040976599 @default.
• W2012849499 hasRelatedWork W2052513855 @default.
• W2012849499 hasRelatedWork W2429210815 @default.
• W2012849499 hasRelatedWork W50742768 @default.
• W2012849499 hasRelatedWork W68975081 @default.
• W2012849499 hasVolume "40" @default.

• next