Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012853846> ?p ?o ?g. }
- W2012853846 endingPage "342" @default.
- W2012853846 startingPage "322" @default.
- W2012853846 abstract "The vectorial transport of bile salts from blood into bile is essential for the generation of bile flow, solubilization of cholesterol in bile, and emulsification of lipids in the intestine. Major transport proteins involved in the enterohepatic circulation of bile salts include the hepatocellular bile salt export pump (BSEP, ABCB11), the apical sodium-dependent bile salt transporter (ASBT, SLC10A2) in cholangiocytes and enterocytes, the sodium-dependent hepatocyte bile salt uptake system NTCP (SLC10A1), the organic anion transporting polypeptides OATP-C (SLC21A6), OATP8 (SLC21A8) and OATP-A (SLC21A3), and the multidrug resistance protein MRP3 (ABCC3). Synthesis and transport of bile salts are intricately linked processes that undergo extensive feedback and feed-forward regulation by transcriptional and posttranscriptional mechanisms. A key regulator of hepatocellular bile salt homeostasis is the bile acid receptor/farnesoid X receptor FXR, which activates transcription of the BSEP and OATP8 genes and of the small heterodimer partner 1 (SHP). SHP is a transcriptional repressor that mediates bile acid-induced repression of the bile salt uptake systems rat Ntcp and human OATP-C. A nuclear receptor that activates rodent Oatp2 (Slc21a5) and human MRP2 (ABCC2) is the pregnane X receptor/steroid X receptor PXR/SXR. Intracellular trafficking and membrane insertion of bile salt transporters is regulated by lipid, protein, and extracellular signal-related kinases in response to physiologic stimuli such as cyclic adenosine monophosphate or taurocholate. Finally, dysfunction of individual bile salt transporters such as BSEP, on account of genetic mutations, steric inhibition, suppression of gene expression, or disturbed signaling, is an important cause of cholestatic liver disease." @default.
- W2012853846 created "2016-06-24" @default.
- W2012853846 creator A5042283235 @default.
- W2012853846 creator A5062829076 @default.
- W2012853846 creator A5089543992 @default.
- W2012853846 date "2004-01-01" @default.
- W2012853846 modified "2023-10-18" @default.
- W2012853846 title "Enterohepatic bile salt transporters in normal physiology and liver disease" @default.
- W2012853846 cites W133736261 @default.
- W2012853846 cites W1524711469 @default.
- W2012853846 cites W1526386980 @default.
- W2012853846 cites W1526388393 @default.
- W2012853846 cites W1545401674 @default.
- W2012853846 cites W1564537703 @default.
- W2012853846 cites W1570388980 @default.
- W2012853846 cites W1586509449 @default.
- W2012853846 cites W1591670239 @default.
- W2012853846 cites W1607399348 @default.
- W2012853846 cites W1651066421 @default.
- W2012853846 cites W1665210332 @default.
- W2012853846 cites W1751757376 @default.
- W2012853846 cites W1802502124 @default.
- W2012853846 cites W1860908381 @default.
- W2012853846 cites W1862042053 @default.
- W2012853846 cites W1862564406 @default.
- W2012853846 cites W1879942467 @default.
- W2012853846 cites W1963755909 @default.
- W2012853846 cites W1966052494 @default.
- W2012853846 cites W1967201184 @default.
- W2012853846 cites W1968320356 @default.
- W2012853846 cites W1968535758 @default.
- W2012853846 cites W1968607001 @default.
- W2012853846 cites W1969586827 @default.
- W2012853846 cites W1969880653 @default.
- W2012853846 cites W1971604750 @default.
- W2012853846 cites W1971649416 @default.
- W2012853846 cites W1972845409 @default.
- W2012853846 cites W1973243569 @default.
- W2012853846 cites W1974599572 @default.
- W2012853846 cites W1975405461 @default.
- W2012853846 cites W1976457322 @default.
- W2012853846 cites W1976621716 @default.
- W2012853846 cites W1977045356 @default.
- W2012853846 cites W1977141350 @default.
- W2012853846 cites W1978017146 @default.
- W2012853846 cites W1978412289 @default.
- W2012853846 cites W1979656599 @default.
- W2012853846 cites W1980479215 @default.
- W2012853846 cites W1984613701 @default.
- W2012853846 cites W1984893706 @default.
- W2012853846 cites W1985460941 @default.
- W2012853846 cites W1987227282 @default.
- W2012853846 cites W1988193927 @default.
- W2012853846 cites W1990722724 @default.
- W2012853846 cites W1990819179 @default.
- W2012853846 cites W1991492489 @default.
- W2012853846 cites W1991834715 @default.
- W2012853846 cites W1992739395 @default.
- W2012853846 cites W1994235168 @default.
- W2012853846 cites W1996011325 @default.
- W2012853846 cites W1997652842 @default.
- W2012853846 cites W1997675547 @default.
- W2012853846 cites W1997947304 @default.
- W2012853846 cites W1998275215 @default.
- W2012853846 cites W1999004536 @default.
- W2012853846 cites W2002121467 @default.
- W2012853846 cites W2003151572 @default.
- W2012853846 cites W2003334133 @default.
- W2012853846 cites W2005320735 @default.
- W2012853846 cites W2007043808 @default.
- W2012853846 cites W2008450021 @default.
- W2012853846 cites W2008825561 @default.
- W2012853846 cites W2009084021 @default.
- W2012853846 cites W2012257016 @default.
- W2012853846 cites W2012910839 @default.
- W2012853846 cites W2015193975 @default.
- W2012853846 cites W2016351055 @default.
- W2012853846 cites W2016573606 @default.
- W2012853846 cites W2016629748 @default.
- W2012853846 cites W2018424848 @default.
- W2012853846 cites W2019532583 @default.
- W2012853846 cites W2020369029 @default.
- W2012853846 cites W2021444563 @default.
- W2012853846 cites W2022186415 @default.
- W2012853846 cites W2027233092 @default.
- W2012853846 cites W2027531328 @default.
- W2012853846 cites W2027663543 @default.
- W2012853846 cites W2028013465 @default.
- W2012853846 cites W2028751507 @default.
- W2012853846 cites W2030026755 @default.
- W2012853846 cites W2030910975 @default.
- W2012853846 cites W2031188909 @default.
- W2012853846 cites W2031580730 @default.
- W2012853846 cites W2031595392 @default.
- W2012853846 cites W2031861312 @default.
- W2012853846 cites W2032033638 @default.
- W2012853846 cites W2032655125 @default.
- W2012853846 cites W2033672481 @default.