Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012863722> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2012863722 endingPage "579" @default.
- W2012863722 startingPage "577" @default.
- W2012863722 abstract "Extracellular nucleotide-induced stimulation and activation of neutrophil in the inflammatory foci followed by chemotaxis in to inflamed vasculature plays a critical role in inflammatory diseases and coronary artery diseases. The extracellular nucleotides stimulate a P2Y receptor(s) on human PMN with the pharmacological profile similar to that of the P2Y2 receptor. Consequent to the activation of P2Y2, arachidonic acid is formed from the membrane bound lipids by phospholipase A2, which subsequently metabolized by 5 lipoxygenase to form the leukotrienes. Of the several leukotrienes generated, LTB 4 is a potent proinflammatory chemokine. Upon its release LTB 4 binds to the PMN by autocrine manner in the same neutrophil and also in a paracrine manner to other neutrophils, leading to the accelerated Mac-1 expression on PMN membrane resulting chemotaxis. Thus it is suggested that the extracellular nucleotide(s) released from the activated platelets and other damaged cell types exacerbate inflammatory response by leukotriene generation. In turn the leukotriene will act in both autocrine and paracrine manner to amplify the process of chemotaxis in PMN by upregulation of Mac-1 expression." @default.
- W2012863722 created "2016-06-24" @default.
- W2012863722 creator A5069388969 @default.
- W2012863722 date "2003-11-01" @default.
- W2012863722 modified "2023-10-17" @default.
- W2012863722 title "Neutrophil chemotaxis: potential role of chemokine receptors in extracellular nucleotide induced Mac-1 expression" @default.
- W2012863722 cites W1489609153 @default.
- W2012863722 cites W1672565987 @default.
- W2012863722 cites W1815757713 @default.
- W2012863722 cites W1947888345 @default.
- W2012863722 cites W1968353682 @default.
- W2012863722 cites W1972195777 @default.
- W2012863722 cites W1975035330 @default.
- W2012863722 cites W2010383714 @default.
- W2012863722 cites W2063670503 @default.
- W2012863722 cites W2072737535 @default.
- W2012863722 cites W2080225527 @default.
- W2012863722 cites W2088629626 @default.
- W2012863722 cites W2095942761 @default.
- W2012863722 doi "https://doi.org/10.1016/s0306-9877(03)00234-2" @default.
- W2012863722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14592789" @default.
- W2012863722 hasPublicationYear "2003" @default.
- W2012863722 type Work @default.
- W2012863722 sameAs 2012863722 @default.
- W2012863722 citedByCount "11" @default.
- W2012863722 countsByYear W20128637222012 @default.
- W2012863722 crossrefType "journal-article" @default.
- W2012863722 hasAuthorship W2012863722A5069388969 @default.
- W2012863722 hasConcept C12823836 @default.
- W2012863722 hasConcept C128240485 @default.
- W2012863722 hasConcept C13373296 @default.
- W2012863722 hasConcept C134897094 @default.
- W2012863722 hasConcept C170493617 @default.
- W2012863722 hasConcept C185592680 @default.
- W2012863722 hasConcept C203014093 @default.
- W2012863722 hasConcept C2776685179 @default.
- W2012863722 hasConcept C2776914184 @default.
- W2012863722 hasConcept C28406088 @default.
- W2012863722 hasConcept C45240729 @default.
- W2012863722 hasConcept C54166955 @default.
- W2012863722 hasConcept C55493867 @default.
- W2012863722 hasConcept C7876069 @default.
- W2012863722 hasConcept C86803240 @default.
- W2012863722 hasConcept C95444343 @default.
- W2012863722 hasConceptScore W2012863722C12823836 @default.
- W2012863722 hasConceptScore W2012863722C128240485 @default.
- W2012863722 hasConceptScore W2012863722C13373296 @default.
- W2012863722 hasConceptScore W2012863722C134897094 @default.
- W2012863722 hasConceptScore W2012863722C170493617 @default.
- W2012863722 hasConceptScore W2012863722C185592680 @default.
- W2012863722 hasConceptScore W2012863722C203014093 @default.
- W2012863722 hasConceptScore W2012863722C2776685179 @default.
- W2012863722 hasConceptScore W2012863722C2776914184 @default.
- W2012863722 hasConceptScore W2012863722C28406088 @default.
- W2012863722 hasConceptScore W2012863722C45240729 @default.
- W2012863722 hasConceptScore W2012863722C54166955 @default.
- W2012863722 hasConceptScore W2012863722C55493867 @default.
- W2012863722 hasConceptScore W2012863722C7876069 @default.
- W2012863722 hasConceptScore W2012863722C86803240 @default.
- W2012863722 hasConceptScore W2012863722C95444343 @default.
- W2012863722 hasIssue "5-6" @default.
- W2012863722 hasLocation W20128637221 @default.
- W2012863722 hasLocation W20128637222 @default.
- W2012863722 hasOpenAccess W2012863722 @default.
- W2012863722 hasPrimaryLocation W20128637221 @default.
- W2012863722 hasRelatedWork W1902473583 @default.
- W2012863722 hasRelatedWork W1974159999 @default.
- W2012863722 hasRelatedWork W2012863722 @default.
- W2012863722 hasRelatedWork W2223116116 @default.
- W2012863722 hasRelatedWork W2903763288 @default.
- W2012863722 hasRelatedWork W2980380964 @default.
- W2012863722 hasRelatedWork W2980670417 @default.
- W2012863722 hasRelatedWork W3179900722 @default.
- W2012863722 hasRelatedWork W3200882416 @default.
- W2012863722 hasRelatedWork W4244962782 @default.
- W2012863722 hasVolume "61" @default.
- W2012863722 isParatext "false" @default.
- W2012863722 isRetracted "false" @default.
- W2012863722 magId "2012863722" @default.
- W2012863722 workType "article" @default.