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- W2012877375 abstract "Institute {or Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111, U.S.A. One of the few central tenets of cellular immunology today is that some antigens can induce antibody syn- thesis without the obvious co-operation of T lympho- cytes while many other antigens require the overt helper function of a subset of T cells for the successful generation of an immune response. The former class of antigens are termed 'thymus-independent' (TI) and the latter 'thymus-dependent' (TD), and this opera- tional definition has been useful even though im- proved techniques for lymphocyte separation have led to the conclusion that some small number of anti- gens may belong in an intermediate category. In practice, the assignment of a given antigen to the TI class always is the result of a negative experiment (the best available method of T-lymphocyte depletion fails significantly to reduce the immune response to the antigen), so that it always is formally possible that a TI antigen will be later reclassified as TD but not" @default.
- W2012877375 created "2016-06-24" @default.
- W2012877375 creator A5019314608 @default.
- W2012877375 creator A5059343866 @default.
- W2012877375 date "1982-08-01" @default.
- W2012877375 modified "2023-09-23" @default.
- W2012877375 title "Thymus-independent antigens: complexity of B-lymphocyte activation revealed" @default.
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- W2012877375 doi "https://doi.org/10.1016/0167-5699(82)90095-0" @default.
- W2012877375 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25289853" @default.
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