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- W2012882076 abstract "Five infants,6 to 14 month old,undernurished of III degree were prospectively studied. All received hypercaloric milk formulas as exclusive diet. At 0-30-60-90 days the following test were done: ceruloplasmin,CBC,serum iron,TIBC,transferrin saturation,FEP,serum ferritin,red blood cell folates. Sequencial CBC were also taken. At the begining of the study bone marrow aspirate,serum protein and long bone x rays were done. In all the patients a copper deficiency was found,they were treated for 90 days as follows: copper sulphate 2.5 mg a day for 30 days,continuing with 1 mg a day till the end of the study. From the 30th day in addition Fe++ 2.5 mg a day was given for 60 days. From the 60th day 1 mg of folic acid was added. Results: A group of 3 infants had a severe copper deficiency with ceruloplasmin 0 mg%, neutropenia < 500 × mm3 and microcitic hypochromic anemia. The other group of 2 infants presented moderate copper deficiency with ceruloplasmin 0 mg%, neutropenia > 1000 and without anemia. During the treatment in both groups a fast recovery of ceruloplasmin and neutrophils were observed. In the first group a constant hematocrit increase was founded with important changes in iron nutrition parameters and folates. In the second group no hematocrit variations was obtained during the exclusive copper therapy and minor variations in iron metabolism and folates were observed." @default.
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- W2012882076 date "1981-02-01" @default.
- W2012882076 modified "2023-09-26" @default.
- W2012882076 title "12 COPPER DEFICIENCY. ORIGIN OF ANEMIA AND NEUTROPENIA IN MAN" @default.
- W2012882076 doi "https://doi.org/10.1203/00006450-198102000-00032" @default.
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