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• W2012887211 abstract "Strong associations exist between tumor necrosis factor-α (TNF-α) and metabolic syndrome (MetS). Although TNF-α is associated with bipolar depression (BD), its role in atypical antipsychotic (AAP)-associated MetS in BD is unclear. Here, we investigate the potential intervening role of TNF-α in the indirect relationship between AAP treatment and MetS in BD.Using a cross-sectional design, 99 euthymic BD volunteers were stratified by the presence or the absence of MetS (National Cholesterol Education Program Adult Treatment Panel III). Serum TNF-α concentration, determined via chemiluminescent immunometric assays, was compared between groups (ie, MetS or no MetS). We investigated the intervening effect of TNF-α on the relation between AAP treatment and MetS in BD using regression techniques.Treatment with those antipsychotics believed associated with a higher risk for MetS (ie, AAPs: olanzapine, quetiapine, risperidone, paliperidone, clozapine) was found to be associated with significantly greater TNF-α (F 1,88 = 11.2, P = 0.001, mean difference of 1.7 ± 0.51) and a higher likelihood of MetS (F 1,88 = 4.5, P = 0.036) than in those not receiving treatment with an AAP. Additionally, TNF-α was greater (trending toward significance; T 52 = 2.0, P = 0.05) in BD volunteers with MetS and was found to have a statistically significant effect on the indirect relationship between AAP treatment and elevated waist circumference in these BD volunteers.These results identify TNF-α as a potential intervening variable of AAP-associated MetS in BD, not previously identified in this population. Future prospective studies could assess the predictive potential of TNF-α in determining risk of AAP-associated MetS in BD. Given previous evidence relating TNF-α and mood state in BD, this study increases the importance in understanding the role of TNF-α in mind-body interactions and renews discussions of the utility of research into the clinical efficacy of TNF-α antagonist treatment in mood disorders." @default.
• W2012887211 created "2016-06-24" @default.
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• W2012887211 date "2013-04-01" @default.
• W2012887211 modified "2023-10-16" @default.
• W2012887211 title "A Pilot Study Investigating Tumor Necrosis Factor-α as a Potential Intervening Variable of Atypical Antipsychotic–Associated Metabolic Syndrome in Bipolar Disorder" @default.
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• W2012887211 doi "https://doi.org/10.1097/ftd.0b013e31827e18d2" @default.
• W2012887211 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3623939" @default.
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