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• W2012893162 abstract "We have used αoligomers as antisense oligonucleotides complementary to three different sequences of the rabbit β-globin mRNA: a region adjacent to the cap site, a region spanning the AUG initiation codon or a sequence in the coding region. These αoligonucleotides were synthesized either with a free 5′ OH group or linked to an acrldine derivative. The effect of these oligonucleotides on mRNA translation was investigated in cell-free extracts and in Xenopus oocytes. In rabbit reticulocyte lysate and in wheat germ extracts oligomers targeted to the cap site and the initiation codon reduced β-globin synthesis in a dose-dependent manner, whereas the target mRNA remained intact. The anti-cap αoligomer was even more efficient that its β-counterpart in rabbit reticulocyte lysate. In contrast, only the α-oligomer,linked to the acridine derivatives, complementary to the cap region displayed significant antisense properties in Xenopuse oocytes. Therefore initiation of translation can be arrested by oligonucleotide/RNA hybrids which are not substrates for RNase-H." @default.
• W2012893162 created "2016-06-24" @default.
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• W2012893162 date "1991-01-01" @default.
• W2012893162 modified "2023-10-17" @default.
• W2012893162 title "Inhibition of translation initiation by antisense oligonucleotides via an RNase-H independent mechanism" @default.
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• W2012893162 doi "https://doi.org/10.1093/nar/19.5.1113" @default.
• W2012893162 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/333789" @default.
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