FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012896317> ?p ?o ?g. }

• W2012896317 endingPage "904" @default.
• W2012896317 startingPage "895" @default.
• W2012896317 abstract "Metabolically generated acid is the major physiological stimulus for increasing proximal tubule citrate reabsorption, which leads to a decrease in citrate excretion. The activity of the Na-citrate cotransporter, NaDC-1, is increased in vivo by acid ingestion and in vitro by an acidic pH medium. In opossum kidney cells the acid stimulatory effect and the ability of endothelin-1 (ET-1) to stimulate NaDC-1 activity are both blocked by the endothelin B (ET(B)) receptor antagonist, BQ788. Acid feeding had no effect on brush border membrane NaDC-1 activity in mice in which ET(B) receptor expression was knocked out, whereas a stimulatory effect was found in wild-type mice. Using ET(A)/ET(B) chimeric and ET(B) C-terminal tail truncated constructs, ET-1 stimulation of NaDC-1 required a receptor C-terminal tail from either ET(A) or ET(B). The ET-1 effect was greatest when either the ET(B) transmembrane domain and C-terminal tail were present or the ET(B) C-terminal tail was linked to the ET(A) transmembrane domain. This effect was smaller when the ET(B) transmembrane domain was linked to the ET(A) C-terminal tail. Thus, the acid-activated pathway mediating stimulation of NaDC-1 activity requires a functional ET(B) receptor in vivo and in vitro, as does acid stimulation of NHE3 activity. Since increased NaDC-1 and NHE3 activities constitute part of the proximal tubule adaptation to an acid load, these studies indicate that there are similarities in the signaling pathway mediating these responses." @default.
• W2012896317 created "2016-06-24" @default.
• W2012896317 creator A5005873362 @default.
• W2012896317 creator A5016370854 @default.
• W2012896317 creator A5021809579 @default.
• W2012896317 creator A5032722053 @default.
• W2012896317 creator A5035732349 @default.
• W2012896317 creator A5074951873 @default.
• W2012896317 creator A5083333758 @default.
• W2012896317 creator A5084169173 @default.
• W2012896317 date "2010-11-01" @default.
• W2012896317 modified "2023-10-11" @default.
• W2012896317 title "Acid regulation of NaDC-1 requires a functional endothelin B receptor" @default.
• W2012896317 cites W1507895014 @default.
• W2012896317 cites W1522018513 @default.
• W2012896317 cites W1978111199 @default.
• W2012896317 cites W1985400548 @default.
• W2012896317 cites W1988524334 @default.
• W2012896317 cites W1998567456 @default.
• W2012896317 cites W1999952424 @default.
• W2012896317 cites W2002562838 @default.
• W2012896317 cites W2005356697 @default.
• W2012896317 cites W2006185273 @default.
• W2012896317 cites W2010078093 @default.
• W2012896317 cites W2018139276 @default.
• W2012896317 cites W2018252235 @default.
• W2012896317 cites W2029820261 @default.
• W2012896317 cites W2032954258 @default.
• W2012896317 cites W2050885954 @default.
• W2012896317 cites W2082819736 @default.
• W2012896317 cites W2095156960 @default.
• W2012896317 cites W2112747245 @default.
• W2012896317 cites W2125704085 @default.
• W2012896317 cites W2133842518 @default.
• W2012896317 cites W2134796677 @default.
• W2012896317 cites W2135628348 @default.
• W2012896317 cites W2139552462 @default.
• W2012896317 cites W2153833534 @default.
• W2012896317 cites W2156403523 @default.
• W2012896317 cites W2164737308 @default.
• W2012896317 cites W2167077199 @default.
• W2012896317 cites W2276541799 @default.
• W2012896317 cites W2295313459 @default.
• W2012896317 cites W2315232639 @default.
• W2012896317 cites W4255858411 @default.
• W2012896317 doi "https://doi.org/10.1038/ki.2010.264" @default.
• W2012896317 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20703215" @default.
• W2012896317 hasPublicationYear "2010" @default.
• W2012896317 type Work @default.
• W2012896317 sameAs 2012896317 @default.
• W2012896317 citedByCount "23" @default.
• W2012896317 countsByYear W20128963172012 @default.
• W2012896317 countsByYear W20128963172013 @default.
• W2012896317 countsByYear W20128963172014 @default.
• W2012896317 countsByYear W20128963172015 @default.
• W2012896317 countsByYear W20128963172016 @default.
• W2012896317 countsByYear W20128963172017 @default.
• W2012896317 countsByYear W20128963172018 @default.
• W2012896317 countsByYear W20128963172019 @default.
• W2012896317 countsByYear W20128963172020 @default.
• W2012896317 countsByYear W20128963172021 @default.
• W2012896317 countsByYear W20128963172022 @default.
• W2012896317 crossrefType "journal-article" @default.
• W2012896317 hasAuthorship W2012896317A5005873362 @default.
• W2012896317 hasAuthorship W2012896317A5016370854 @default.
• W2012896317 hasAuthorship W2012896317A5021809579 @default.
• W2012896317 hasAuthorship W2012896317A5032722053 @default.
• W2012896317 hasAuthorship W2012896317A5035732349 @default.
• W2012896317 hasAuthorship W2012896317A5074951873 @default.
• W2012896317 hasAuthorship W2012896317A5083333758 @default.
• W2012896317 hasAuthorship W2012896317A5084169173 @default.
• W2012896317 hasBestOaLocation W20128963171 @default.
• W2012896317 hasConcept C126322002 @default.
• W2012896317 hasConcept C134018914 @default.
• W2012896317 hasConcept C149601957 @default.
• W2012896317 hasConcept C150903083 @default.
• W2012896317 hasConcept C170493617 @default.
• W2012896317 hasConcept C178790620 @default.
• W2012896317 hasConcept C185592680 @default.
• W2012896317 hasConcept C188053792 @default.
• W2012896317 hasConcept C207001950 @default.
• W2012896317 hasConcept C24998067 @default.
• W2012896317 hasConcept C2780091579 @default.
• W2012896317 hasConcept C537181965 @default.
• W2012896317 hasConcept C55493867 @default.
• W2012896317 hasConcept C56906281 @default.
• W2012896317 hasConcept C71924100 @default.
• W2012896317 hasConcept C86803240 @default.
• W2012896317 hasConceptScore W2012896317C126322002 @default.
• W2012896317 hasConceptScore W2012896317C134018914 @default.
• W2012896317 hasConceptScore W2012896317C149601957 @default.
• W2012896317 hasConceptScore W2012896317C150903083 @default.
• W2012896317 hasConceptScore W2012896317C170493617 @default.
• W2012896317 hasConceptScore W2012896317C178790620 @default.
• W2012896317 hasConceptScore W2012896317C185592680 @default.
• W2012896317 hasConceptScore W2012896317C188053792 @default.
• W2012896317 hasConceptScore W2012896317C207001950 @default.
• W2012896317 hasConceptScore W2012896317C24998067 @default.

• next