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- W2012902521 abstract "This study develops a mathematical model for calculating the tumour oxygen consumption rate and investigates the correlation with tumour volume. Near-infrared spectroscopy (NIRS) was used to measure changes of oxygenated haemoglobin concentration (?[HbO2]) before and after potassium chloride (KCl) induced cardiac arrest. Measurements were made in five 13762NF mammary adenocarcinomas implanted in female adult Fisher 344 rats, while the anaesthetized rats breathed air. After 5?10?min of baseline NIRS measurement, KCl overdose was administered intravenously in the tail. NIRS showed a significant drop in tumour vascular oxygenation immediately following KCl induced cardiac arrest. The tumour oxygen consumption rate was calculated by fitting the model to the measured ?[HbO2] data, and a relationship between the tumour oxygen consumption rate and tumour volume was analysed using linear regression. A strong negative linear relationship was found between the mean tumour oxygen consumption rate and tumour volume. This study demonstrates that the NIRS can provide an efficient and real-time approach to quantify tumour oxygen consumption rate, while further development is required to make it non-invasive." @default.
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- W2012902521 date "2005-07-22" @default.
- W2012902521 modified "2023-10-16" @default.
- W2012902521 title "Investigation of rat breast tumour oxygen consumption by near-infrared spectroscopy" @default.
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- W2012902521 doi "https://doi.org/10.1088/0022-3727/38/15/021" @default.
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