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- W2012904123 abstract "The superior diastolic blood pressure reduction (BP) of high‐dose combination therapy with trandolapril (Tr) and verapamil‐SR (Ve) compared with monotherapy has previously been reported. Guideline changes, placing greater emphasis on systolic BP, prompted a re‐evaluation of TV‐51 and an assessment of a subset of patients from the INternational VErapamil‐SR Trandolapril STudy (INVEST). The objective of this analysis was to determine if the short‐term antihypertensive effects of high‐dose Tr+Ve (Tr/Ve study) could be confirmed in a sample of higher‐risk INVEST patients with longer follow‐up. The Tr/Ve study was a double‐blind, randomized, parallel‐group, placebo‐controlled trial to evaluate the antihypertensive effects of trandolapril and verapamil‐SR alone or in combination in 631 patients randomized to placebo, 4 mg trandolapril, 240 mg verapamil‐SR or 4mg/240mg Tr+Ve combination for 6 weeks; 581 INVEST patients were selected for comparison with 24‐month BP data, 90% use of trandolapril and verapamil‐SR combination therapy and no triple therapy. Tr+Ve combination treatment achieved significantly greater systolic and diastolic BP reduction versus monotherapy. The BP‐lowering effects of high‐dose Tr+Ve achieved during short‐term treatment were confirmed in INVEST during longer follow‐up. Despite differences in the risk profiles of previously studied patients and INVEST patients, the antihypertensive effects of Ve+Tr were similar." @default.
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- W2012904123 date "2007-01-01" @default.
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- W2012904123 title "Antihypertensive properties of a high‐dose combination of trandolapril and verapamil‐SR" @default.
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- W2012904123 doi "https://doi.org/10.1080/08038020600744582" @default.
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