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- W2012912228 abstract "Background: The purpose of this study was to elucidate why odontogenic keratocysts (OKC) can form cystic lesions but not tumor masses, notwithstanding their prominent proliferative activity. Methods: We investigated cellular proliferation, cell death, and expression of apoptosis‐related proteins in the lining cells of OKCs and of dentigerous cysts (DGCs). Results: TdT‐mediated dUTP‐biotin nick end labeling (TUNEL)‐positive cells were observed in the surface layers of OKCs and of DGCs. However, no TUNEL‐positive cells were seen in the basal or intermediate layers of both cysts. Ki67‐positive ratio in the intermediate layer was the highest in OKCs. The p53‐positive ratio of the intermediate layer was highest in OKCs. Bcl‐2‐positive cells were discernible exclusively in the basal layer of OKCs. Conclusions: These results suggest that cellular proliferation and death is regulated in association with apoptosis‐related proteins in the lining epithelia of OKCs, and subsequently those cysts are seen as cystic lesions but not as tumor masses." @default.
- W2012912228 created "2016-06-24" @default.
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- W2012912228 date "2005-03-30" @default.
- W2012912228 modified "2023-10-15" @default.
- W2012912228 title "Cell proliferation, apoptosis and apoptosis-related factors in odontogenic keratocysts and in dentigerous cysts" @default.
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- W2012912228 doi "https://doi.org/10.1111/j.1600-0714.2005.00314.x" @default.
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