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• W2012912679 abstract "The development of novel antimicrobial agents having high selectivity toward bacterial cells over mammalian cells is urgently required to curb the widespread emergence of infectious diseases caused by pathogenic bacteria. Toward this end, we have developed a set of cationic dimeric amphiphiles (bearing cleavable amide linkages between the headgroup and the hydrocarbon tail with different methylene spacers) that showed high antibacterial activity against human pathogenic bacteria (Escherichia coli and Staphylococcus aureus) and low cytotoxicity. The Minimum Inhibitory Concentrations (MIC) were found to be very low for the dimeric amphiphiles and were lower or comparable to the monomeric counterpart. In the case of dimeric amphiphiles, MIC was found to decrease with the increase in the spacer chain length (n = 2 to 6) and again to increase at higher spacer length (n > 6). It was found that the compound with six methylene spacers was the most active among all of the amphiphiles (MICs = 10-13 μM). By fluorescence spectroscopy, fluorescence microscopy, and field-emission scanning electron microscopy (FESEM), it was revealed that these cationic amphiphiles interact with the negatively charged bacterial cell membrane and disrupt the membrane integrity, thus killing the bacteria. All of the cationic amphiphiles showed low hemolytic activity (HC(50)) and high selectivity against both gram-positive and gram-negative bacteria. The most active amphiphile (n = 6) had a 10-13-fold higher HC(50) than did the MIC. Also, this amphiphile did not show any cytotoxicity against mammalian cells (HeLa cells) even at a concentration above the MIC (20 μM). The critical micellar concentration (CMC) values of gemini surfactants were found to be very low (CMC = 0.30-0.11 mM) and were 10-27 times smaller than the corresponding monomeric analogue (CMC = 2.9 mM). Chemical hydrolysis and thermogravimetric analysis (TGA) proved that these amphiphiles are quite stable under both acidic and thermal conditions. Collectively, these properties make the newly synthesized amphiphiles potentially superior disinfectants and antiseptics for various biomedical and biotechnological applications." @default.
• W2012912679 created "2016-06-24" @default.
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• W2012912679 date "2012-08-08" @default.
• W2012912679 modified "2023-09-29" @default.
• W2012912679 title "Cleavable Cationic Antibacterial Amphiphiles: Synthesis, Mechanism of Action, and Cytotoxicities" @default.
• W2012912679 cites W1517744955 @default.
• W2012912679 cites W1598136901 @default.
• W2012912679 cites W1964894938 @default.
• W2012912679 cites W1966084369 @default.
• W2012912679 cites W1968497746 @default.
• W2012912679 cites W1970845333 @default.
• W2012912679 cites W1972581429 @default.
• W2012912679 cites W1974194706 @default.
• W2012912679 cites W1979973356 @default.
• W2012912679 cites W1980320854 @default.
• W2012912679 cites W1980926666 @default.
• W2012912679 cites W1983410492 @default.
• W2012912679 cites W1984870247 @default.
• W2012912679 cites W1986153977 @default.
• W2012912679 cites W1986286007 @default.
• W2012912679 cites W1986326797 @default.
• W2012912679 cites W1993906884 @default.
• W2012912679 cites W1993995978 @default.
• W2012912679 cites W1997152791 @default.
• W2012912679 cites W1998966261 @default.
• W2012912679 cites W1999876290 @default.
• W2012912679 cites W2002787967 @default.
• W2012912679 cites W2003493354 @default.
• W2012912679 cites W2007331931 @default.
• W2012912679 cites W2011376158 @default.
• W2012912679 cites W2019066144 @default.
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• W2012912679 cites W2019930935 @default.
• W2012912679 cites W2022112316 @default.
• W2012912679 cites W2036337946 @default.
• W2012912679 cites W2036628662 @default.
• W2012912679 cites W2038512626 @default.
• W2012912679 cites W2038968326 @default.
• W2012912679 cites W2039510774 @default.
• W2012912679 cites W2040641713 @default.
• W2012912679 cites W2042487849 @default.
• W2012912679 cites W2042656577 @default.
• W2012912679 cites W2047090400 @default.
• W2012912679 cites W2050140989 @default.
• W2012912679 cites W2051154783 @default.
• W2012912679 cites W2051158595 @default.
• W2012912679 cites W2054602599 @default.
• W2012912679 cites W2057514251 @default.
• W2012912679 cites W2058952776 @default.
• W2012912679 cites W2066959435 @default.
• W2012912679 cites W2071404078 @default.
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• W2012912679 cites W2131380952 @default.
• W2012912679 cites W2131565767 @default.
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• W2012912679 cites W2951334879 @default.
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• W2012912679 cites W4231635416 @default.
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• W2012912679 doi "https://doi.org/10.1021/la302303d" @default.
• W2012912679 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22838496" @default.
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