Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012912776> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2012912776 endingPage "63" @default.
- W2012912776 startingPage "49" @default.
- W2012912776 abstract "The humoral immune response against α(l→3) dextran (Dex) in BALB/c mice is characterized by the formation of predominantly IgM antibodies bearing the J558 idiotype. IgG antibodies do not appear in euthymic mice. In athymic animals, however, the response proceeds to a vigorous IgG production. In euthymic mice formation of IgG is suppressed by J558 idiotype specific regulatory T cells recognizing in association with I-Ed and in cognate T/B interaction the VH CDR3 derived peptide of the J558 idiotype. Only B-2 lymphocytes produce IgG whereas B-1 cells do not participate in the production of this Ig class. Using novel synthetic all α(1→3)-D-gluco configurated tetrasaccharide the Dex-specific B cells can for the first time be analyzed in FACS. In experiments using this newly designed low molecular Dex no signs of B cell apoptosis can be found. This demonstrates a true silencing of persisting Bγ memory cells as previously suggested by adoptive transfer experiments. In this suppression a further involvement of CD28 and B7-1 interaction can be demonstrated which delivers a necessary costimulatory suppression signal in addition to the cognate TCR/peptide-I-Ed interaction beween J558 specific T cells and J558 idiotype bearing B cells." @default.
- W2012912776 created "2016-06-24" @default.
- W2012912776 creator A5012124060 @default.
- W2012912776 creator A5038262324 @default.
- W2012912776 creator A5043269865 @default.
- W2012912776 creator A5047552166 @default.
- W2012912776 creator A5048257990 @default.
- W2012912776 creator A5058593568 @default.
- W2012912776 date "1999-09-01" @default.
- W2012912776 modified "2023-10-18" @default.
- W2012912776 title "Involvement of CD28 Cosignalling in the T Cell-Mediated Suppression of the IgG Antibody Response against the TI-2 Antigen α(1→3) Dextran" @default.
- W2012912776 cites W1529773650 @default.
- W2012912776 cites W1606782385 @default.
- W2012912776 cites W1652509807 @default.
- W2012912776 cites W1897024726 @default.
- W2012912776 cites W1963562796 @default.
- W2012912776 cites W1981152986 @default.
- W2012912776 cites W1988422289 @default.
- W2012912776 cites W2017596457 @default.
- W2012912776 cites W2019345195 @default.
- W2012912776 cites W2024292761 @default.
- W2012912776 cites W2042621160 @default.
- W2012912776 cites W2055669282 @default.
- W2012912776 cites W2056671237 @default.
- W2012912776 cites W2061540100 @default.
- W2012912776 cites W2061927365 @default.
- W2012912776 cites W2078547612 @default.
- W2012912776 cites W2078843264 @default.
- W2012912776 cites W2094468094 @default.
- W2012912776 cites W2125430697 @default.
- W2012912776 cites W2134812217 @default.
- W2012912776 doi "https://doi.org/10.1016/s0171-2985(99)80046-1" @default.
- W2012912776 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10532280" @default.
- W2012912776 hasPublicationYear "1999" @default.
- W2012912776 type Work @default.
- W2012912776 sameAs 2012912776 @default.
- W2012912776 citedByCount "5" @default.
- W2012912776 crossrefType "journal-article" @default.
- W2012912776 hasAuthorship W2012912776A5012124060 @default.
- W2012912776 hasAuthorship W2012912776A5038262324 @default.
- W2012912776 hasAuthorship W2012912776A5043269865 @default.
- W2012912776 hasAuthorship W2012912776A5047552166 @default.
- W2012912776 hasAuthorship W2012912776A5048257990 @default.
- W2012912776 hasAuthorship W2012912776A5058593568 @default.
- W2012912776 hasConcept C147483822 @default.
- W2012912776 hasConcept C148125776 @default.
- W2012912776 hasConcept C153911025 @default.
- W2012912776 hasConcept C159654299 @default.
- W2012912776 hasConcept C185592680 @default.
- W2012912776 hasConcept C19317047 @default.
- W2012912776 hasConcept C203014093 @default.
- W2012912776 hasConcept C2776090121 @default.
- W2012912776 hasConcept C2778453870 @default.
- W2012912776 hasConcept C542903549 @default.
- W2012912776 hasConcept C74505204 @default.
- W2012912776 hasConcept C86803240 @default.
- W2012912776 hasConcept C8891405 @default.
- W2012912776 hasConcept C90375314 @default.
- W2012912776 hasConceptScore W2012912776C147483822 @default.
- W2012912776 hasConceptScore W2012912776C148125776 @default.
- W2012912776 hasConceptScore W2012912776C153911025 @default.
- W2012912776 hasConceptScore W2012912776C159654299 @default.
- W2012912776 hasConceptScore W2012912776C185592680 @default.
- W2012912776 hasConceptScore W2012912776C19317047 @default.
- W2012912776 hasConceptScore W2012912776C203014093 @default.
- W2012912776 hasConceptScore W2012912776C2776090121 @default.
- W2012912776 hasConceptScore W2012912776C2778453870 @default.
- W2012912776 hasConceptScore W2012912776C542903549 @default.
- W2012912776 hasConceptScore W2012912776C74505204 @default.
- W2012912776 hasConceptScore W2012912776C86803240 @default.
- W2012912776 hasConceptScore W2012912776C8891405 @default.
- W2012912776 hasConceptScore W2012912776C90375314 @default.
- W2012912776 hasIssue "1" @default.
- W2012912776 hasLocation W20129127761 @default.
- W2012912776 hasLocation W20129127762 @default.
- W2012912776 hasOpenAccess W2012912776 @default.
- W2012912776 hasPrimaryLocation W20129127761 @default.
- W2012912776 hasRelatedWork W1930743608 @default.
- W2012912776 hasRelatedWork W1976270794 @default.
- W2012912776 hasRelatedWork W2014891488 @default.
- W2012912776 hasRelatedWork W2054999194 @default.
- W2012912776 hasRelatedWork W2063323573 @default.
- W2012912776 hasRelatedWork W2064077365 @default.
- W2012912776 hasRelatedWork W2072345275 @default.
- W2012912776 hasRelatedWork W2075890355 @default.
- W2012912776 hasRelatedWork W2076243094 @default.
- W2012912776 hasRelatedWork W3029500041 @default.
- W2012912776 hasVolume "201" @default.
- W2012912776 isParatext "false" @default.
- W2012912776 isRetracted "false" @default.
- W2012912776 magId "2012912776" @default.
- W2012912776 workType "article" @default.