Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012927900> ?p ?o ?g. }
- W2012927900 endingPage "2500" @default.
- W2012927900 startingPage "2483" @default.
- W2012927900 abstract "Aims: Macrophage (MΦ) infiltration during myocardial infarction (MI) amplifies cardiac inflammation and remodeling. We investigated whether activation of the NRLP3 inflammasome by a calcium sensing receptor (CaSR) in MΦ subsets contributes to cardiac remodeling following MI. Methods and Results: Infiltrated MΦ exhibited biphasic activation after MI; M1MΦ peaked at MI 3d and decreased until MI 14d, whereas M2MΦ peaked at MI 7d and decreased at MI 14d as shown via immunohistochemistry. IL-1β co-infiltrated with both M1MΦ and M2MΦ; IL-1β exhibited the same infiltrating tendency as M1MΦ, which was detected by immunohistochemistry. Increasing ventricular fibrosis was confirmed by Masson staining. CaSR and NLRP3 inflammasome in the MI group were upregulated in MΦ subsets in myocardium and peritoneal MΦ (p-MΦ) compared with the sham groups which were detected by immunofluorescence and western blotting. CaSR-activated NLRP3 inflammasome played a role in M1MΦ via PLC-IP3 but did not play a role in M2MΦ which were polarized by the THP-1 as shown by western blotting and intracellular calcium measurement. CaSR/NLRP3 inflammasome activation in M1MΦ led to the following effects: upregulated α-sma, MMP-2 and MMP-9, and collagen secretion; and downregulated TIMP-2 in cardiac fibroblasts via IL-1β-IL-1RI, which was detected by coculturing M1MΦ and cardiac fibroblasts. Conclusions: We suggest that the CaSR/NLRP3 inflammasome plays an essential role via the PLC-IP3 pathway in M1MΦ to promote cardiac remodeling post-MI in rats, including accelerated cardiac fibroblast phenotypic transversion, increased collagen and extracellular matrix (ECM) secretion; however, the CaSR/NLRP3 inflammasome does not play a role in this process in M2MΦ." @default.
- W2012927900 created "2016-06-24" @default.
- W2012927900 creator A5001937247 @default.
- W2012927900 creator A5006651636 @default.
- W2012927900 creator A5007999482 @default.
- W2012927900 creator A5017200569 @default.
- W2012927900 creator A5037172649 @default.
- W2012927900 creator A5039629749 @default.
- W2012927900 creator A5048895247 @default.
- W2012927900 creator A5049644175 @default.
- W2012927900 creator A5060361805 @default.
- W2012927900 creator A5091620323 @default.
- W2012927900 date "2015-01-01" @default.
- W2012927900 modified "2023-10-01" @default.
- W2012927900 title "Activation in M1 but not M2 Macrophages Contributes to Cardiac Remodeling after Myocardial Infarction in Rats: a Critical Role of the Calcium Sensing Receptor/NRLP3 Inflammasome" @default.
- W2012927900 cites W1503505561 @default.
- W2012927900 cites W1510017290 @default.
- W2012927900 cites W1572259854 @default.
- W2012927900 cites W1845689355 @default.
- W2012927900 cites W1889002087 @default.
- W2012927900 cites W1971915082 @default.
- W2012927900 cites W1976731065 @default.
- W2012927900 cites W1981044204 @default.
- W2012927900 cites W1984338631 @default.
- W2012927900 cites W1986660466 @default.
- W2012927900 cites W1987329700 @default.
- W2012927900 cites W1992010324 @default.
- W2012927900 cites W1994029289 @default.
- W2012927900 cites W1995253472 @default.
- W2012927900 cites W1995638940 @default.
- W2012927900 cites W1996507370 @default.
- W2012927900 cites W1998988555 @default.
- W2012927900 cites W2009441758 @default.
- W2012927900 cites W2010592415 @default.
- W2012927900 cites W2013243629 @default.
- W2012927900 cites W2013471060 @default.
- W2012927900 cites W2016878697 @default.
- W2012927900 cites W2020744745 @default.
- W2012927900 cites W2037600884 @default.
- W2012927900 cites W2050506186 @default.
- W2012927900 cites W2051658957 @default.
- W2012927900 cites W2057954455 @default.
- W2012927900 cites W2061448989 @default.
- W2012927900 cites W2071517838 @default.
- W2012927900 cites W2114389121 @default.
- W2012927900 cites W2118221757 @default.
- W2012927900 cites W2118403357 @default.
- W2012927900 cites W2120815988 @default.
- W2012927900 cites W2128060092 @default.
- W2012927900 cites W2135683612 @default.
- W2012927900 cites W2145190952 @default.
- W2012927900 cites W2146684396 @default.
- W2012927900 cites W2156403998 @default.
- W2012927900 cites W2159004384 @default.
- W2012927900 cites W2159366550 @default.
- W2012927900 cites W2162173979 @default.
- W2012927900 cites W2164229991 @default.
- W2012927900 cites W2169804106 @default.
- W2012927900 cites W2170168704 @default.
- W2012927900 doi "https://doi.org/10.1159/000374048" @default.
- W2012927900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25967877" @default.
- W2012927900 hasPublicationYear "2015" @default.
- W2012927900 type Work @default.
- W2012927900 sameAs 2012927900 @default.
- W2012927900 citedByCount "76" @default.
- W2012927900 countsByYear W20129279002016 @default.
- W2012927900 countsByYear W20129279002017 @default.
- W2012927900 countsByYear W20129279002018 @default.
- W2012927900 countsByYear W20129279002019 @default.
- W2012927900 countsByYear W20129279002020 @default.
- W2012927900 countsByYear W20129279002021 @default.
- W2012927900 countsByYear W20129279002022 @default.
- W2012927900 countsByYear W20129279002023 @default.
- W2012927900 crossrefType "journal-article" @default.
- W2012927900 hasAuthorship W2012927900A5001937247 @default.
- W2012927900 hasAuthorship W2012927900A5006651636 @default.
- W2012927900 hasAuthorship W2012927900A5007999482 @default.
- W2012927900 hasAuthorship W2012927900A5017200569 @default.
- W2012927900 hasAuthorship W2012927900A5037172649 @default.
- W2012927900 hasAuthorship W2012927900A5039629749 @default.
- W2012927900 hasAuthorship W2012927900A5048895247 @default.
- W2012927900 hasAuthorship W2012927900A5049644175 @default.
- W2012927900 hasAuthorship W2012927900A5060361805 @default.
- W2012927900 hasAuthorship W2012927900A5091620323 @default.
- W2012927900 hasBestOaLocation W20129279001 @default.
- W2012927900 hasConcept C104317684 @default.
- W2012927900 hasConcept C126322002 @default.
- W2012927900 hasConcept C127561419 @default.
- W2012927900 hasConcept C134018914 @default.
- W2012927900 hasConcept C142590548 @default.
- W2012927900 hasConcept C170493617 @default.
- W2012927900 hasConcept C185592680 @default.
- W2012927900 hasConcept C2776914184 @default.
- W2012927900 hasConcept C2777209026 @default.
- W2012927900 hasConcept C2777420927 @default.
- W2012927900 hasConcept C2779537366 @default.
- W2012927900 hasConcept C2780559512 @default.
- W2012927900 hasConcept C500558357 @default.