FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012932406> ?p ?o ?g. }

• W2012932406 endingPage "e100513" @default.
• W2012932406 startingPage "e100513" @default.
• W2012932406 abstract "CD97 is a widely expressed adhesion class G-protein-coupled receptor (aGPCR). Here, we investigated the presence of CD97 in normal and malignant human skeletal muscle as well as the ultrastructural and functional consequences of CD97 deficiency in mice. In normal human skeletal muscle, CD97 was expressed at the peripheral sarcolemma of all myofibers, as revealed by immunostaining of tissue sections and surface labeling of single myocytes using flow cytometry. In muscle cross-sections, an intracellular polygonal, honeycomb-like CD97-staining pattern, typical for molecules located in the T-tubule or sarcoplasmatic reticulum (SR), was additionally found. CD97 co-localized with SR Ca2+-ATPase (SERCA), a constituent of the longitudinal SR, but not with the receptors for dihydropyridine (DHPR) or ryanodine (RYR), located in the T-tubule and terminal SR, respectively. Intracellular expression of CD97 was higher in slow-twitch compared to most fast-twitch myofibers. In rhabdomyosarcomas, CD97 was strongly upregulated and in part more N-glycosylated compared to normal skeletal muscle. All tumors were strongly CD97-positive, independent of the underlying histological subtype, suggesting high sensitivity of CD97 for this tumor. Ultrastructural analysis of murine skeletal myofibers confirmed the location of CD97 in the SR. CD97 knock-out mice had a dilated SR, resulting in a partial increase in triad diameter yet not affecting the T-tubule, sarcomeric, and mitochondrial structure. Despite these obvious ultrastructural changes, intracellular Ca2+ release from single myofibers, force generation and fatigability of isolated soleus muscles, and wheel-running capacity of mice were not affected by the lack of CD97. We conclude that CD97 is located in the SR and at the peripheral sarcolemma of human and murine skeletal muscle, where its absence affects the structure of the SR without impairing skeletal muscle function." @default.
• W2012932406 created "2016-06-24" @default.
• W2012932406 creator A5004801433 @default.
• W2012932406 creator A5010946359 @default.
• W2012932406 creator A5011107306 @default.
• W2012932406 creator A5021116855 @default.
• W2012932406 creator A5038761581 @default.
• W2012932406 creator A5047533498 @default.
• W2012932406 creator A5054408949 @default.
• W2012932406 creator A5060136306 @default.
• W2012932406 creator A5064872740 @default.
• W2012932406 creator A5065351929 @default.
• W2012932406 creator A5081700551 @default.
• W2012932406 creator A5090162618 @default.
• W2012932406 creator A5090299482 @default.
• W2012932406 date "2014-06-20" @default.
• W2012932406 modified "2023-10-18" @default.
• W2012932406 title "Skeletal Muscle Expression of the Adhesion-GPCR CD97: CD97 Deletion Induces an Abnormal Structure of the Sarcoplasmatic Reticulum but Does Not Impair Skeletal Muscle Function" @default.
• W2012932406 cites W1528760252 @default.
• W2012932406 cites W1552651901 @default.
• W2012932406 cites W1558371851 @default.
• W2012932406 cites W1583577648 @default.
• W2012932406 cites W1919230608 @default.
• W2012932406 cites W1936362758 @default.
• W2012932406 cites W1965173162 @default.
• W2012932406 cites W1981158262 @default.
• W2012932406 cites W1984842433 @default.
• W2012932406 cites W1992062945 @default.
• W2012932406 cites W1995016025 @default.
• W2012932406 cites W2008430800 @default.
• W2012932406 cites W2013636098 @default.
• W2012932406 cites W2017317593 @default.
• W2012932406 cites W2017365291 @default.
• W2012932406 cites W2041491674 @default.
• W2012932406 cites W2045268402 @default.
• W2012932406 cites W2050170351 @default.
• W2012932406 cites W2055018361 @default.
• W2012932406 cites W2067146747 @default.
• W2012932406 cites W2076271057 @default.
• W2012932406 cites W2080689645 @default.
• W2012932406 cites W2083356518 @default.
• W2012932406 cites W2087606375 @default.
• W2012932406 cites W2099987453 @default.
• W2012932406 cites W2103538258 @default.
• W2012932406 cites W2106273483 @default.
• W2012932406 cites W2111605834 @default.
• W2012932406 cites W2111689719 @default.
• W2012932406 cites W2140858431 @default.
• W2012932406 cites W2146497075 @default.
• W2012932406 cites W2147204470 @default.
• W2012932406 cites W2148927308 @default.
• W2012932406 cites W2148968067 @default.
• W2012932406 cites W2150633163 @default.
• W2012932406 cites W2151218235 @default.
• W2012932406 cites W2154507105 @default.
• W2012932406 cites W2161331106 @default.
• W2012932406 cites W2163039494 @default.
• W2012932406 cites W2170167354 @default.
• W2012932406 cites W68451256 @default.
• W2012932406 doi "https://doi.org/10.1371/journal.pone.0100513" @default.
• W2012932406 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4065095" @default.
• W2012932406 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24949957" @default.
• W2012932406 hasPublicationYear "2014" @default.
• W2012932406 type Work @default.
• W2012932406 sameAs 2012932406 @default.
• W2012932406 citedByCount "11" @default.
• W2012932406 countsByYear W20129324062015 @default.
• W2012932406 countsByYear W20129324062016 @default.
• W2012932406 countsByYear W20129324062019 @default.
• W2012932406 countsByYear W20129324062020 @default.
• W2012932406 countsByYear W20129324062021 @default.
• W2012932406 countsByYear W20129324062022 @default.
• W2012932406 countsByYear W20129324062023 @default.
• W2012932406 crossrefType "journal-article" @default.
• W2012932406 hasAuthorship W2012932406A5004801433 @default.
• W2012932406 hasAuthorship W2012932406A5010946359 @default.
• W2012932406 hasAuthorship W2012932406A5011107306 @default.
• W2012932406 hasAuthorship W2012932406A5021116855 @default.
• W2012932406 hasAuthorship W2012932406A5038761581 @default.
• W2012932406 hasAuthorship W2012932406A5047533498 @default.
• W2012932406 hasAuthorship W2012932406A5054408949 @default.
• W2012932406 hasAuthorship W2012932406A5060136306 @default.
• W2012932406 hasAuthorship W2012932406A5064872740 @default.
• W2012932406 hasAuthorship W2012932406A5065351929 @default.
• W2012932406 hasAuthorship W2012932406A5081700551 @default.
• W2012932406 hasAuthorship W2012932406A5090162618 @default.
• W2012932406 hasAuthorship W2012932406A5090299482 @default.
• W2012932406 hasBestOaLocation W20129324061 @default.
• W2012932406 hasConcept C11171543 @default.
• W2012932406 hasConcept C113217602 @default.
• W2012932406 hasConcept C126322002 @default.
• W2012932406 hasConcept C134018914 @default.
• W2012932406 hasConcept C15744967 @default.
• W2012932406 hasConcept C158617107 @default.
• W2012932406 hasConcept C176038584 @default.
• W2012932406 hasConcept C181199279 @default.
• W2012932406 hasConcept C185592680 @default.
• W2012932406 hasConcept C199096232 @default.

• next