FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012932421> ?p ?o ?g. }

• W2012932421 endingPage "63" @default.
• W2012932421 startingPage "57" @default.
• W2012932421 abstract "Donepezil hydrochloride (donepezil: (+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-indan-1-one monohydrochloride) is a potent acetylcholinesterase inhibitor used for treatment of Alzheimer's disease. Although acetylcholinesterase inhibitors are used as a symptomatic treatment for Alzheimer's disease, it is not clear whether or not they are effective against progressive degeneration of neuronal cells. In this study, we investigated the neuroprotective effects of donepezil and other acetylcholinesterase inhibitors used for treatment of Alzheimer's disease, i.e., galantamine, rivastigmine, and tacrine. As a neurodegenerative model, we used rat cortical neurons exposed to oxygen-glucose deprivation. Lactate dehydrogenase (LDH) released into the culture medium was measured as a marker of neuronal cell damage. First, the effects of donepezil (10 microM) on three different treatment schedules (from 12 h before to 24 h after oxygen-glucose deprivation (pre-12 h), from 1 h before to 24 h after oxygen-glucose deprivation (pre-1 h) and from 1 h after to 24 h after oxygen-glucose deprivation (post-1 h)) were compared. The pre-12-h treatment most effectively inhibited LDH release. The protective effect of donepezil was confirmed morphologically. Next, the effects of donepezil and the other three acetylcholinesterase inhibitors were compared under the pre-12-h treatment condition. Donepezil (0.1, 1, and 10 microM) significantly decreased LDH release in a concentration-dependent manner. However, galantamine (1, 10, and 100 microM), tacrine (0.1, 1, and 10 microM), and rivastigmine (0.1, 1, and 10 microM) did not significantly decrease LDH release. The neuroprotective effect of donepezil was not antagonized by scopolamine or mecamylamine. These results demonstrate that donepezil has a protective effect against oxygen-glucose deprivation-induced injury to rat primary cultured cerebral cortical neurons. Besides, it is suggested that this effect of donepezil is independent of muscarinic cholinergic system and nicotinic cholinergic system. Thus, donepezil is expected to have a protective effect against progressive degeneration of brain neuronal cells in ischemic cerebrovascular disease and Alzheimer's disease." @default.
• W2012932421 created "2016-06-24" @default.
• W2012932421 creator A5003751302 @default.
• W2012932421 creator A5051525612 @default.
• W2012932421 creator A5067200402 @default.
• W2012932421 creator A5081839064 @default.
• W2012932421 date "2003-07-01" @default.
• W2012932421 modified "2023-10-03" @default.
• W2012932421 title "Protective effect of donepezil in a primary culture of rat cortical neurons exposed to oxygen–glucose deprivation" @default.
• W2012932421 cites W1546522923 @default.
• W2012932421 cites W1966030100 @default.
• W2012932421 cites W1979243823 @default.
• W2012932421 cites W1980766639 @default.
• W2012932421 cites W1985215852 @default.
• W2012932421 cites W1999054724 @default.
• W2012932421 cites W2013350002 @default.
• W2012932421 cites W2018097963 @default.
• W2012932421 cites W2025774809 @default.
• W2012932421 cites W2031053930 @default.
• W2012932421 cites W2041026703 @default.
• W2012932421 cites W2044037918 @default.
• W2012932421 cites W2054162453 @default.
• W2012932421 cites W2085273994 @default.
• W2012932421 cites W2092677781 @default.
• W2012932421 cites W2099452732 @default.
• W2012932421 cites W2099945778 @default.
• W2012932421 cites W2102493638 @default.
• W2012932421 cites W2138394292 @default.
• W2012932421 cites W2144816691 @default.
• W2012932421 cites W2156688243 @default.
• W2012932421 cites W2165773859 @default.
• W2012932421 cites W68643383 @default.
• W2012932421 doi "https://doi.org/10.1016/s0014-2999(03)01865-x" @default.
• W2012932421 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12860473" @default.
• W2012932421 hasPublicationYear "2003" @default.
• W2012932421 type Work @default.
• W2012932421 sameAs 2012932421 @default.
• W2012932421 citedByCount "70" @default.
• W2012932421 countsByYear W20129324212012 @default.
• W2012932421 countsByYear W20129324212013 @default.
• W2012932421 countsByYear W20129324212014 @default.
• W2012932421 countsByYear W20129324212015 @default.
• W2012932421 countsByYear W20129324212016 @default.
• W2012932421 countsByYear W20129324212017 @default.
• W2012932421 countsByYear W20129324212019 @default.
• W2012932421 countsByYear W20129324212021 @default.
• W2012932421 countsByYear W20129324212022 @default.
• W2012932421 countsByYear W20129324212023 @default.
• W2012932421 crossrefType "journal-article" @default.
• W2012932421 hasAuthorship W2012932421A5003751302 @default.
• W2012932421 hasAuthorship W2012932421A5051525612 @default.
• W2012932421 hasAuthorship W2012932421A5067200402 @default.
• W2012932421 hasAuthorship W2012932421A5081839064 @default.
• W2012932421 hasConcept C126322002 @default.
• W2012932421 hasConcept C181199279 @default.
• W2012932421 hasConcept C185592680 @default.
• W2012932421 hasConcept C25498285 @default.
• W2012932421 hasConcept C2776332859 @default.
• W2012932421 hasConcept C2777318727 @default.
• W2012932421 hasConcept C2777544248 @default.
• W2012932421 hasConcept C2778816929 @default.
• W2012932421 hasConcept C2779046751 @default.
• W2012932421 hasConcept C2779056891 @default.
• W2012932421 hasConcept C2779134260 @default.
• W2012932421 hasConcept C2779483572 @default.
• W2012932421 hasConcept C2780904820 @default.
• W2012932421 hasConcept C31896038 @default.
• W2012932421 hasConcept C502032728 @default.
• W2012932421 hasConcept C55493867 @default.
• W2012932421 hasConcept C71924100 @default.
• W2012932421 hasConcept C98274493 @default.
• W2012932421 hasConceptScore W2012932421C126322002 @default.
• W2012932421 hasConceptScore W2012932421C181199279 @default.
• W2012932421 hasConceptScore W2012932421C185592680 @default.
• W2012932421 hasConceptScore W2012932421C25498285 @default.
• W2012932421 hasConceptScore W2012932421C2776332859 @default.
• W2012932421 hasConceptScore W2012932421C2777318727 @default.
• W2012932421 hasConceptScore W2012932421C2777544248 @default.
• W2012932421 hasConceptScore W2012932421C2778816929 @default.
• W2012932421 hasConceptScore W2012932421C2779046751 @default.
• W2012932421 hasConceptScore W2012932421C2779056891 @default.
• W2012932421 hasConceptScore W2012932421C2779134260 @default.
• W2012932421 hasConceptScore W2012932421C2779483572 @default.
• W2012932421 hasConceptScore W2012932421C2780904820 @default.
• W2012932421 hasConceptScore W2012932421C31896038 @default.
• W2012932421 hasConceptScore W2012932421C502032728 @default.
• W2012932421 hasConceptScore W2012932421C55493867 @default.
• W2012932421 hasConceptScore W2012932421C71924100 @default.
• W2012932421 hasConceptScore W2012932421C98274493 @default.
• W2012932421 hasIssue "1-2" @default.
• W2012932421 hasLocation W20129324211 @default.
• W2012932421 hasLocation W20129324212 @default.
• W2012932421 hasOpenAccess W2012932421 @default.
• W2012932421 hasPrimaryLocation W20129324211 @default.
• W2012932421 hasRelatedWork W1461127813 @default.
• W2012932421 hasRelatedWork W1985503561 @default.
• W2012932421 hasRelatedWork W2017645489 @default.
• W2012932421 hasRelatedWork W2063268875 @default.

• next