Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012932684> ?p ?o ?g. }
- W2012932684 endingPage "3231" @default.
- W2012932684 startingPage "3221" @default.
- W2012932684 abstract "The Rho family of small GTPases play a pivotal role in the dynamic regulation of the actin cytoskeleton. Recent studies have suggested that these signalling proteins also have wide-ranging functions in membrane trafficking pathways. The Rho family member RhoB was shown to localise to vesicles of the endocytic compartment, suggesting a potential function in regulation of endocytic traffic. In keeping with this, we have previously shown that expression of active RhoB causes a delay in the intracellular trafficking of the epidermal growth factor (EGF) receptor; however, the site of action of RhoB within the endocytic pathway is still unknown. RhoB exists as two prenylated forms in cells: geranylgeranylated RhoB (RhoB-GG) and farnesylated RhoB (RhoB-F). Here we use farnesyltransferase inhibitors (FTIs) to show that prenylation specifies the cellular localisation of RhoB. RhoB-GG localises to multivesicular late endosomes and farnesylated RhoB (RhoB-F) localises to the plasma membrane. The gain of endosomal RhoB-GG elicited by FTI treatment reduces sorting of EGF receptor to the lysosome and increases recycling to the plasma membrane. Ultrastructural analysis shows that activation of RhoB through drug treatment or mutation has no effect the sorting of receptor into late endosomes, but instead inhibits the subsequent transfer of late endosomal receptor to the lysosome." @default.
- W2012932684 created "2016-06-24" @default.
- W2012932684 creator A5025481585 @default.
- W2012932684 creator A5048265536 @default.
- W2012932684 creator A5068913126 @default.
- W2012932684 creator A5082181446 @default.
- W2012932684 date "2004-07-01" @default.
- W2012932684 modified "2023-10-11" @default.
- W2012932684 title "Farnesyltransferase inhibitors disrupt EGF receptor traffic through modulation of the RhoB GTPase" @default.
- W2012932684 cites W1508097413 @default.
- W2012932684 cites W1517546728 @default.
- W2012932684 cites W1523918896 @default.
- W2012932684 cites W1821459756 @default.
- W2012932684 cites W1848923750 @default.
- W2012932684 cites W1910650341 @default.
- W2012932684 cites W1964633722 @default.
- W2012932684 cites W1965028987 @default.
- W2012932684 cites W1965995529 @default.
- W2012932684 cites W1966242743 @default.
- W2012932684 cites W1968826282 @default.
- W2012932684 cites W1970920351 @default.
- W2012932684 cites W1974653642 @default.
- W2012932684 cites W1976127915 @default.
- W2012932684 cites W1990934479 @default.
- W2012932684 cites W1995574514 @default.
- W2012932684 cites W1996286203 @default.
- W2012932684 cites W1999441881 @default.
- W2012932684 cites W2010577277 @default.
- W2012932684 cites W2011897485 @default.
- W2012932684 cites W2014018734 @default.
- W2012932684 cites W2017098460 @default.
- W2012932684 cites W2019987740 @default.
- W2012932684 cites W2028248159 @default.
- W2012932684 cites W2035477123 @default.
- W2012932684 cites W2052043073 @default.
- W2012932684 cites W2054246670 @default.
- W2012932684 cites W2058111213 @default.
- W2012932684 cites W2059431360 @default.
- W2012932684 cites W2060957113 @default.
- W2012932684 cites W2062977562 @default.
- W2012932684 cites W2067005574 @default.
- W2012932684 cites W2067374132 @default.
- W2012932684 cites W2079472461 @default.
- W2012932684 cites W2089906643 @default.
- W2012932684 cites W2092654348 @default.
- W2012932684 cites W2094630875 @default.
- W2012932684 cites W2094703210 @default.
- W2012932684 cites W2097645517 @default.
- W2012932684 cites W2098432765 @default.
- W2012932684 cites W2098924026 @default.
- W2012932684 cites W2101218054 @default.
- W2012932684 cites W2101496796 @default.
- W2012932684 cites W2105746559 @default.
- W2012932684 cites W2121042036 @default.
- W2012932684 cites W2125589729 @default.
- W2012932684 cites W2133708306 @default.
- W2012932684 cites W2133837411 @default.
- W2012932684 cites W2137045315 @default.
- W2012932684 cites W2151429860 @default.
- W2012932684 cites W2157502463 @default.
- W2012932684 cites W2160996325 @default.
- W2012932684 cites W2163985137 @default.
- W2012932684 cites W2168946425 @default.
- W2012932684 cites W2169290377 @default.
- W2012932684 cites W2171205888 @default.
- W2012932684 cites W2303125984 @default.
- W2012932684 cites W3023026532 @default.
- W2012932684 cites W4239814545 @default.
- W2012932684 doi "https://doi.org/10.1242/jcs.01193" @default.
- W2012932684 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15226397" @default.
- W2012932684 hasPublicationYear "2004" @default.
- W2012932684 type Work @default.
- W2012932684 sameAs 2012932684 @default.
- W2012932684 citedByCount "111" @default.
- W2012932684 countsByYear W20129326842012 @default.
- W2012932684 countsByYear W20129326842013 @default.
- W2012932684 countsByYear W20129326842014 @default.
- W2012932684 countsByYear W20129326842015 @default.
- W2012932684 countsByYear W20129326842016 @default.
- W2012932684 countsByYear W20129326842017 @default.
- W2012932684 countsByYear W20129326842018 @default.
- W2012932684 countsByYear W20129326842019 @default.
- W2012932684 countsByYear W20129326842020 @default.
- W2012932684 countsByYear W20129326842021 @default.
- W2012932684 countsByYear W20129326842022 @default.
- W2012932684 countsByYear W20129326842023 @default.
- W2012932684 crossrefType "journal-article" @default.
- W2012932684 hasAuthorship W2012932684A5025481585 @default.
- W2012932684 hasAuthorship W2012932684A5048265536 @default.
- W2012932684 hasAuthorship W2012932684A5068913126 @default.
- W2012932684 hasAuthorship W2012932684A5082181446 @default.
- W2012932684 hasBestOaLocation W20129326841 @default.
- W2012932684 hasConcept C102747710 @default.
- W2012932684 hasConcept C170493617 @default.
- W2012932684 hasConcept C181199279 @default.
- W2012932684 hasConcept C207332259 @default.
- W2012932684 hasConcept C2777093181 @default.
- W2012932684 hasConcept C2778917187 @default.