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• W2012935431 abstract "The human 8q24 gene desert contains multiple enhancers that form tissue-specific long-range chromatin loops with the MYC oncogene, but how chromatin looping at the MYC locus is regulated remains poorly understood. Here we demonstrate that a long noncoding RNA (lncRNA), CCAT1-L, is transcribed specifically in human colorectal cancers from a locus 515 kb upstream of MYC. This lncRNA plays a role in MYC transcriptional regulation and promotes long-range chromatin looping. Importantly, the CCAT1-L locus is located within a strong super-enhancer and is spatially close to MYC. Knockdown of CCAT1-L reduced long-range interactions between the MYC promoter and its enhancers. In addition, CCAT1-L interacts with CTCF and modulates chromatin conformation at these loop regions. These results reveal an important role of a previously unannotated lncRNA in gene regulation at the MYC locus." @default.
• W2012935431 created "2016-06-24" @default.
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• W2012935431 date "2014-03-25" @default.
• W2012935431 modified "2023-10-17" @default.
• W2012935431 title "Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus" @default.
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• W2012935431 doi "https://doi.org/10.1038/cr.2014.35" @default.
• W2012935431 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4152739" @default.
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