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• W2012940513 abstract "Pyrithiamine-induced thiamine deficiency (PTD) was used to produce a rodent model of Wernicke–Korsakoff syndrome that results in acute neurological disturbances, thalamic lesions, and learning and memory impairments. There is also cholinergic septohippocampal dysfunction in the PTD model. Systemic (Experiment 1) and intrahippocampal (Experiment 2) injections of the acetylcholinesterase inhibitor physostigmine were administered to determine if increasing acetylcholine levels would eliminate the behavioral impairment produced by PTD. Prior to spontaneous alternation testing, rats received injections of either physostigmine (systemic = 0.075 mg/kg; intrahippocampal = 20, 40 ng/μL) or saline. In Experiment 2, intrahippocampal injections of physostigmine significantly enhanced alternation rates in the PTD-treated rats. In addition, although intrahippocampal infusions of 40 ng of physostigmine increased the available amount of ACh in both pair-fed (PF) and PTD rats, it did so to a greater extent in PF rats. The increase in ACh levels induced by the direct hippocampal application of physostigmine in the PTD model likely increased activation of the extended limbic system, which was dysfunctional, and therefore led to recovery of function on the spontaneous alternation task. In contrast, the lack of behavioral improvement by intrahippocampal physostigmine infusion in the PF rats, despite a greater rise in hippocampal ACh levels, supports the theory that there is an optimal range of cholinergic tone for optimal behavioral and hippocampal function." @default.
• W2012940513 created "2016-06-24" @default.
• W2012940513 creator A5029497057 @default.
• W2012940513 creator A5053848138 @default.
• W2012940513 creator A5061240937 @default.
• W2012940513 creator A5077109422 @default.
• W2012940513 date "2008-10-01" @default.
• W2012940513 modified "2023-10-08" @default.
• W2012940513 title "Increasing hippocampal acetylcholine levels enhance behavioral performance in an animal model of diencephalic amnesia" @default.
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• W2012940513 doi "https://doi.org/10.1016/j.brainres.2008.07.090" @default.
• W2012940513 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2614338" @default.

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