Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012945687> ?p ?o ?g. }
- W2012945687 endingPage "2739" @default.
- W2012945687 startingPage "2731" @default.
- W2012945687 abstract "Abstract Single nucleotide polymorphism arrays (SNP-A) have recently been widely applied as a powerful karyotyping tool in numerous translational cancer studies. SNP-A complements traditional metaphase cytogenetics with the unique ability to delineate a previously hidden chromosomal defect, copy neutral loss of heterozygosity (CN-LOH). Emerging data demonstrate that selected hematologic malignancies exhibit abundant CN-LOH, often in the setting of a normal metaphase karyotype and no previously identified clonal marker. In this review, we explore emerging biologic and clinical features of CN-LOH relevant to hematologic malignancies. In myeloid malignancies, CN-LOH has been associated with the duplication of oncogenic mutations with concomitant loss of the normal allele. Examples include JAK2, MPL, c-KIT, and FLT3. More recent investigations have focused on evaluation of candidate genes contained in common CN-LOH and deletion regions and have led to the discovery of tumor suppressor genes, including c-CBL and family members, as well as TET2. Investigations into the underlying mechanisms generating CN-LOH have great promise for elucidating general cancer mechanisms. We anticipate that further detailed characterization of CN-LOH lesions will probably facilitate our discovery of a more complete set of pathogenic molecular lesions, disease and prognosis markers, and better understanding of the initiation and progression of hematologic malignancies." @default.
- W2012945687 created "2016-06-24" @default.
- W2012945687 creator A5072987784 @default.
- W2012945687 creator A5078527108 @default.
- W2012945687 creator A5085974329 @default.
- W2012945687 date "2010-04-08" @default.
- W2012945687 modified "2023-09-30" @default.
- W2012945687 title "Copy neutral loss of heterozygosity: a novel chromosomal lesion in myeloid malignancies" @default.
- W2012945687 cites W1502393135 @default.
- W2012945687 cites W1964295470 @default.
- W2012945687 cites W1968002146 @default.
- W2012945687 cites W1970375103 @default.
- W2012945687 cites W1973850616 @default.
- W2012945687 cites W1977052779 @default.
- W2012945687 cites W1980568348 @default.
- W2012945687 cites W1983602304 @default.
- W2012945687 cites W1984065010 @default.
- W2012945687 cites W1987453064 @default.
- W2012945687 cites W1987577960 @default.
- W2012945687 cites W1988275985 @default.
- W2012945687 cites W1988633385 @default.
- W2012945687 cites W1997671124 @default.
- W2012945687 cites W2001048486 @default.
- W2012945687 cites W2001931464 @default.
- W2012945687 cites W2005276393 @default.
- W2012945687 cites W2007214149 @default.
- W2012945687 cites W2007389278 @default.
- W2012945687 cites W2010512581 @default.
- W2012945687 cites W2013726626 @default.
- W2012945687 cites W2013738288 @default.
- W2012945687 cites W2015391036 @default.
- W2012945687 cites W2018764412 @default.
- W2012945687 cites W2022930434 @default.
- W2012945687 cites W2023773505 @default.
- W2012945687 cites W2031916348 @default.
- W2012945687 cites W2032703975 @default.
- W2012945687 cites W2038244338 @default.
- W2012945687 cites W2039234691 @default.
- W2012945687 cites W2039356250 @default.
- W2012945687 cites W2041152829 @default.
- W2012945687 cites W2041724441 @default.
- W2012945687 cites W2046311586 @default.
- W2012945687 cites W2048434099 @default.
- W2012945687 cites W2052024543 @default.
- W2012945687 cites W2052721941 @default.
- W2012945687 cites W2053817716 @default.
- W2012945687 cites W2058449327 @default.
- W2012945687 cites W2059143188 @default.
- W2012945687 cites W2059852420 @default.
- W2012945687 cites W2071128187 @default.
- W2012945687 cites W2073449138 @default.
- W2012945687 cites W2075776925 @default.
- W2012945687 cites W2078017786 @default.
- W2012945687 cites W2079349819 @default.
- W2012945687 cites W2082312262 @default.
- W2012945687 cites W2083276287 @default.
- W2012945687 cites W2084334750 @default.
- W2012945687 cites W2088375930 @default.
- W2012945687 cites W2094186176 @default.
- W2012945687 cites W2096717046 @default.
- W2012945687 cites W2098739456 @default.
- W2012945687 cites W2104479178 @default.
- W2012945687 cites W2113802211 @default.
- W2012945687 cites W2115721890 @default.
- W2012945687 cites W2116526365 @default.
- W2012945687 cites W2118943389 @default.
- W2012945687 cites W2122550449 @default.
- W2012945687 cites W2126150922 @default.
- W2012945687 cites W2129359631 @default.
- W2012945687 cites W2135284044 @default.
- W2012945687 cites W2140247198 @default.
- W2012945687 cites W2144126823 @default.
- W2012945687 cites W2145342515 @default.
- W2012945687 cites W2150536104 @default.
- W2012945687 cites W2153362877 @default.
- W2012945687 cites W2157838058 @default.
- W2012945687 cites W2160854895 @default.
- W2012945687 cites W2163688965 @default.
- W2012945687 cites W2164143675 @default.
- W2012945687 cites W2169172058 @default.
- W2012945687 cites W2201323538 @default.
- W2012945687 cites W2395930097 @default.
- W2012945687 doi "https://doi.org/10.1182/blood-2009-10-201848" @default.
- W2012945687 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2854422" @default.
- W2012945687 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20107230" @default.
- W2012945687 hasPublicationYear "2010" @default.
- W2012945687 type Work @default.
- W2012945687 sameAs 2012945687 @default.
- W2012945687 citedByCount "194" @default.
- W2012945687 countsByYear W20129456872012 @default.
- W2012945687 countsByYear W20129456872013 @default.
- W2012945687 countsByYear W20129456872014 @default.
- W2012945687 countsByYear W20129456872015 @default.
- W2012945687 countsByYear W20129456872016 @default.
- W2012945687 countsByYear W20129456872017 @default.
- W2012945687 countsByYear W20129456872018 @default.
- W2012945687 countsByYear W20129456872019 @default.
- W2012945687 countsByYear W20129456872020 @default.