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- W2012964104 abstract "In 1957 Akerfeldt 1 reported that when the N,N-dimethyl form of p -phenylenediamine (PPD) is added to serum the PPD becomes oxidized to a red-colored substance. He found that serum from schizophrenic patients oxidized PPD at a faster rate than serum from normal controls. A rapid rate of oxidation was also found in a large percentage of patients with liver disease, neoplasm, and pregnancy in the last trimester. 2 In this reaction a 0.1% solution of N,N-dimethyl- p -phenylenediamine is added to an equal quantity of serum. The increase in optical density is then measured spectrophotometrically for six minutes at wavelength 552 mμ. A time curve is then derived which is believed to be the resultant of a number of factors in serum, 3 among which are ascorbic acid concentration, ceruloplasmin activity, and certain sulfhydryl compounds. (A typical curve is shown in Figure 1.) The lag period before the initial" @default.
- W2012964104 created "2016-06-24" @default.
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- W2012964104 date "1959-05-01" @default.
- W2012964104 modified "2023-10-14" @default.
- W2012964104 title "An Effect of Exercise, Skin Shock, and Ascorbic Acid on Serum Oxidase Activity" @default.
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- W2012964104 doi "https://doi.org/10.1001/archneurpsyc.1959.02340170086009" @default.
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