FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012982706> ?p ?o ?g. }

• W2012982706 endingPage "2639" @default.
• W2012982706 startingPage "2633" @default.
• W2012982706 abstract "The Middle Cerebral Artery Embolism Local Fibrinolytic Intervention Trial (MELT) Japan was organized to determine the safety and clinical efficacy of intraarterial infusion of urokinase (UK) in patients with stroke within 6 hours of onset.Patients with ischemic stroke presenting within 6 hours of onset and displaying occlusions of the M1 or M2 portion of the middle cerebral artery on carotid angiography were randomized to the UK or control groups. Clinical outcome was assessed by the modified Rankin Scale, National Institutes of Health Stroke Scale, and Barthel Index.The Independent Monitoring Committee recommended stopping the trial after approval of intravenous infusion of recombinant tissue plasminogen activator in Japan. A total of 114 patients underwent randomization, 57 patients in each group. Background characteristics were comparable between the 2 groups. The primary end point of favorable outcome (modified Rankin Scale 0 to 2) at 90 days was somewhat more frequent in the UK group than in the control group (49.1% and 38.6%, OR: 1.54, 95% CI: 0.73 to 3.23) but did not reach a significant level (P=0.345). However, excellent functional outcome (modified Rankin Scale 0 to 1) at 90 days, a preplanned secondary end point, was more frequent in the UK group than in the control group (42.1% and 22.8%, P=0.045, OR: 2.46, 95% CI: 1.09 to 5.54). There were significantly more patients with National Institutes of Health Stroke Scale 0 or 1 at 90 days in the UK group than the control group (P=0.017). The 90-day cumulative mortality was 5.3% in the UK group and 3.5% in the control group (P=1.000), and intracerebral hemorrhage within 24 hours of treatment occurred in 9% and 2%, respectively (P=0.206).The trial was aborted prematurely and the primary end point did not reach statistical significance. Nevertheless, the secondary analyses suggested that intraarterial fibrinolysis has the potential to increase the likelihood of excellent functional outcome." @default.
• W2012982706 created "2016-06-24" @default.
• W2012982706 creator A5011179401 @default.
• W2012982706 creator A5023019678 @default.
• W2012982706 creator A5036244962 @default.
• W2012982706 creator A5042534277 @default.
• W2012982706 creator A5048258194 @default.
• W2012982706 creator A5050144186 @default.
• W2012982706 creator A5072564461 @default.
• W2012982706 creator A5079975386 @default.
• W2012982706 creator A5091161390 @default.
• W2012982706 date "2007-10-01" @default.
• W2012982706 modified "2023-09-26" @default.
• W2012982706 title "Randomized Trial of Intraarterial Infusion of Urokinase Within 6 Hours of Middle Cerebral Artery Stroke" @default.
• W2012982706 cites W1967149686 @default.
• W2012982706 cites W1972353723 @default.
• W2012982706 cites W1973913902 @default.
• W2012982706 cites W2026456381 @default.
• W2012982706 cites W2061751634 @default.
• W2012982706 cites W2075518123 @default.
• W2012982706 cites W2081769749 @default.
• W2012982706 cites W2087605514 @default.
• W2012982706 cites W2098032054 @default.
• W2012982706 cites W2099706007 @default.
• W2012982706 cites W2118738743 @default.
• W2012982706 cites W2129357435 @default.
• W2012982706 cites W2138423664 @default.
• W2012982706 cites W2151968079 @default.
• W2012982706 cites W2157281786 @default.
• W2012982706 cites W2292308933 @default.
• W2012982706 cites W2471537412 @default.
• W2012982706 cites W2531503442 @default.
• W2012982706 cites W4292339830 @default.
• W2012982706 cites W70903732 @default.
• W2012982706 doi "https://doi.org/10.1161/strokeaha.107.488551" @default.
• W2012982706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17702958" @default.
• W2012982706 hasPublicationYear "2007" @default.
• W2012982706 type Work @default.
• W2012982706 sameAs 2012982706 @default.
• W2012982706 citedByCount "441" @default.
• W2012982706 countsByYear W20129827062012 @default.
• W2012982706 countsByYear W20129827062013 @default.
• W2012982706 countsByYear W20129827062014 @default.
• W2012982706 countsByYear W20129827062015 @default.
• W2012982706 countsByYear W20129827062016 @default.
• W2012982706 countsByYear W20129827062017 @default.
• W2012982706 countsByYear W20129827062018 @default.
• W2012982706 countsByYear W20129827062019 @default.
• W2012982706 countsByYear W20129827062020 @default.
• W2012982706 countsByYear W20129827062021 @default.
• W2012982706 countsByYear W20129827062022 @default.
• W2012982706 countsByYear W20129827062023 @default.
• W2012982706 crossrefType "journal-article" @default.
• W2012982706 hasAuthorship W2012982706A5011179401 @default.
• W2012982706 hasAuthorship W2012982706A5023019678 @default.
• W2012982706 hasAuthorship W2012982706A5036244962 @default.
• W2012982706 hasAuthorship W2012982706A5042534277 @default.
• W2012982706 hasAuthorship W2012982706A5048258194 @default.
• W2012982706 hasAuthorship W2012982706A5050144186 @default.
• W2012982706 hasAuthorship W2012982706A5072564461 @default.
• W2012982706 hasAuthorship W2012982706A5079975386 @default.
• W2012982706 hasAuthorship W2012982706A5091161390 @default.
• W2012982706 hasBestOaLocation W20129827061 @default.
• W2012982706 hasConcept C126322002 @default.
• W2012982706 hasConcept C127413603 @default.
• W2012982706 hasConcept C141071460 @default.
• W2012982706 hasConcept C168563851 @default.
• W2012982706 hasConcept C203092338 @default.
• W2012982706 hasConcept C204243189 @default.
• W2012982706 hasConcept C2775841333 @default.
• W2012982706 hasConcept C2776892390 @default.
• W2012982706 hasConcept C2780645631 @default.
• W2012982706 hasConcept C2780931571 @default.
• W2012982706 hasConcept C3020199598 @default.
• W2012982706 hasConcept C42219234 @default.
• W2012982706 hasConcept C535046627 @default.
• W2012982706 hasConcept C541997718 @default.
• W2012982706 hasConcept C71924100 @default.
• W2012982706 hasConcept C78519656 @default.
• W2012982706 hasConceptScore W2012982706C126322002 @default.
• W2012982706 hasConceptScore W2012982706C127413603 @default.
• W2012982706 hasConceptScore W2012982706C141071460 @default.
• W2012982706 hasConceptScore W2012982706C168563851 @default.
• W2012982706 hasConceptScore W2012982706C203092338 @default.
• W2012982706 hasConceptScore W2012982706C204243189 @default.
• W2012982706 hasConceptScore W2012982706C2775841333 @default.
• W2012982706 hasConceptScore W2012982706C2776892390 @default.
• W2012982706 hasConceptScore W2012982706C2780645631 @default.
• W2012982706 hasConceptScore W2012982706C2780931571 @default.
• W2012982706 hasConceptScore W2012982706C3020199598 @default.
• W2012982706 hasConceptScore W2012982706C42219234 @default.
• W2012982706 hasConceptScore W2012982706C535046627 @default.
• W2012982706 hasConceptScore W2012982706C541997718 @default.
• W2012982706 hasConceptScore W2012982706C71924100 @default.
• W2012982706 hasConceptScore W2012982706C78519656 @default.
• W2012982706 hasIssue "10" @default.
• W2012982706 hasLocation W20129827061 @default.
• W2012982706 hasLocation W20129827062 @default.

• next