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- W2012988304 abstract "To determine whether chronic angiotensin II (Ang II) type I receptor (ATR) antagonism improves recovery of left ventricular (LV) function after ischemia-reperfusion (IR) and increases AT,R and Ang II type 2 receptor (AT 2 R) protein expression in isolated working rat hearts, rats were randomized to pretreatment with either losartan (30 mg/kg/day) or UP269-6 (3 mg/kg/day), or no drug (control), for 1 week or 3 weeks before IR (50 min perfusion, 25 min ischemia, 40 min reperfusion). In vitro LV work and power and ex vivo AT,R and AT 2 R proteins (immunoblots) were measured. Compared to baseline perfusion, LV work and power showed variable recovery in control, losartan, and UP269-6 groups. Compared to control, losartan preserved recovery of LV work and power while UP269-6 showed less recovery after IR at both 1 week and 3 weeks. Both antagonists increased AT 2 R but not AT,R protein. The duration of pretreatment did not affect the expression of ATR or AT 2 R proteins. The results indicate that chronic AT,R blockade over 1 or 3 weeks increases AT 2 R (not ATIR) protein expression and may preserve but not improve postischemic functional recovery compared to controls in isolated working rat hearts." @default.
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- W2012988304 date "2001-06-01" @default.
- W2012988304 modified "2023-09-24" @default.
- W2012988304 title "Effect of Chronic AT1 Receptor Antagonism on Postischemic Functional Recovery and AT1/AT2 Receptor Proteins in Isolated Working Rat Hearts" @default.
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- W2012988304 doi "https://doi.org/10.1177/107424840100600210" @default.
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