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- W2012989539 endingPage "375" @default.
- W2012989539 startingPage "355" @default.
- W2012989539 abstract "Boron neutron capture therapy (BNCT) is based on the preferential targeting of tumor cells with (10)B and subsequent activation with thermal neutrons to produce a highly localized radiation. In theory, it is possible to selectively irradiate a tumor and the associated infiltrating tumor cells with large single doses of high-LET radiation while sparing the adjacent normal tissues. The mixture of high- and low-LET dose components created in tissue during neutron irradiation complicates the radiobiology of BNCT. Much of the complexity has been unravelled through a combination of preclinical experimentation and clinical dose escalation experience. Over 350 patients have been treated in a number of different facilities worldwide. The accumulated clinical experience has demonstrated that BNCT can be delivered safely but is still defining the limits of normal brain tolerance. Several independent BNCT clinical protocols have demonstrated that BNCT can produce median survivals in patients with glioblastoma that appear to be equivalent to conventional photon therapy. This review describes the individual components and methodologies required for effect BNCT: the boron delivery agents; the analytical techniques; the neutron beams; the dosimetry and radiation biology measurements; and how these components have been integrated into a series of clinical studies. The single greatest weakness of BNCT at the present time is non-uniform delivery of boron into all tumor cells. Future improvements in BNCT effectiveness will come from improved boron delivery agents, improved boron administration protocols, or through combination of BNCT with other modalities." @default.
- W2012989539 created "2016-06-24" @default.
- W2012989539 creator A5001063819 @default.
- W2012989539 creator A5004332266 @default.
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- W2012989539 creator A5015428535 @default.
- W2012989539 creator A5023913184 @default.
- W2012989539 creator A5078915962 @default.
- W2012989539 date "2003-10-01" @default.
- W2012989539 modified "2023-10-10" @default.
- W2012989539 title "Boron Neutron Capture Therapy: Cellular Targeting of High Linear Energy Transfer Radiation" @default.
- W2012989539 cites W1247052291 @default.
- W2012989539 cites W134080584 @default.
- W2012989539 cites W141434044 @default.
- W2012989539 cites W147704120 @default.
- W2012989539 cites W1558863261 @default.
- W2012989539 cites W1581886599 @default.
- W2012989539 cites W170806990 @default.
- W2012989539 cites W180313986 @default.
- W2012989539 cites W18253019 @default.
- W2012989539 cites W187225084 @default.
- W2012989539 cites W1873944504 @default.
- W2012989539 cites W1905286104 @default.
- W2012989539 cites W1934324555 @default.
- W2012989539 cites W1949438132 @default.
- W2012989539 cites W1965838160 @default.
- W2012989539 cites W1970556497 @default.
- W2012989539 cites W1972038810 @default.
- W2012989539 cites W1977392502 @default.
- W2012989539 cites W1977934288 @default.
- W2012989539 cites W1979037465 @default.
- W2012989539 cites W1979126480 @default.
- W2012989539 cites W1985538171 @default.
- W2012989539 cites W1991142673 @default.
- W2012989539 cites W1992133515 @default.
- W2012989539 cites W1996099807 @default.
- W2012989539 cites W1996863402 @default.
- W2012989539 cites W2001660159 @default.
- W2012989539 cites W2004939389 @default.
- W2012989539 cites W2007657675 @default.
- W2012989539 cites W2009217240 @default.
- W2012989539 cites W2012124868 @default.
- W2012989539 cites W2012200796 @default.
- W2012989539 cites W2018690980 @default.
- W2012989539 cites W2019425530 @default.
- W2012989539 cites W2019845574 @default.
- W2012989539 cites W2020821501 @default.
- W2012989539 cites W2023024303 @default.
- W2012989539 cites W2025853365 @default.
- W2012989539 cites W2029200505 @default.
- W2012989539 cites W2033996844 @default.
- W2012989539 cites W2038263015 @default.
- W2012989539 cites W2042560297 @default.
- W2012989539 cites W2048668469 @default.
- W2012989539 cites W2050756955 @default.
- W2012989539 cites W2050834311 @default.
- W2012989539 cites W2051307955 @default.
- W2012989539 cites W2051757792 @default.
- W2012989539 cites W2052321259 @default.
- W2012989539 cites W2053344788 @default.
- W2012989539 cites W2054232940 @default.
- W2012989539 cites W2063847863 @default.
- W2012989539 cites W2067043175 @default.
- W2012989539 cites W2069255784 @default.
- W2012989539 cites W2069589091 @default.
- W2012989539 cites W2071533736 @default.
- W2012989539 cites W2079488899 @default.
- W2012989539 cites W2082614165 @default.
- W2012989539 cites W2084526557 @default.
- W2012989539 cites W2088472732 @default.
- W2012989539 cites W2088682243 @default.
- W2012989539 cites W2089954351 @default.
- W2012989539 cites W2090716553 @default.
- W2012989539 cites W2092903037 @default.
- W2012989539 cites W2095424297 @default.
- W2012989539 cites W2097512974 @default.
- W2012989539 cites W2097670451 @default.
- W2012989539 cites W2097807191 @default.
- W2012989539 cites W2101335232 @default.
- W2012989539 cites W2103875971 @default.
- W2012989539 cites W2111002016 @default.
- W2012989539 cites W2143210785 @default.
- W2012989539 cites W2151051629 @default.
- W2012989539 cites W2154510366 @default.
- W2012989539 cites W2155460816 @default.
- W2012989539 cites W2163176102 @default.
- W2012989539 cites W2166455547 @default.
- W2012989539 cites W2170967865 @default.
- W2012989539 cites W2202998915 @default.
- W2012989539 cites W2234068060 @default.
- W2012989539 cites W2266866961 @default.
- W2012989539 cites W2324383846 @default.
- W2012989539 cites W2324739686 @default.
- W2012989539 cites W2325770298 @default.
- W2012989539 cites W2334892113 @default.
- W2012989539 cites W233548966 @default.
- W2012989539 cites W2444395074 @default.
- W2012989539 cites W2502783538 @default.