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- W2012996875 startingPage "161" @default.
- W2012996875 abstract "Pancreatic beta-cell mass expands through beta-cell proliferation and neogenesis while it decreases mainly via apoptosis. The loss of balance between beta-cell death and regeneration leads to a reduction of beta-cell functional mass, thus contributing to the pathogenesis of type 2 diabetes mellitus (T2DM). The pathogenetic mechanisms causing T2DM are complex, and also include a significant reduction of the incretin effect. A better understanding of the role of incretin hormones in glucose homeostasis has led to the development of incretin-based therapies. Recently, incretin hormones have been shown to stimulate the beta-cell growth and differentiation from pancreas-derived stem/progenitor cells, as well as to exert cytoprotective, antiapoptotic effects on beta-cells. However, the role and the molecular mechanisms by which GLP-1 and its agonists regulate beta-cell mass have not been fully investigated. This review focuses the current findings and the missing understanding of the effects of incretin hormones on beta-cell mass expansion." @default.
- W2012996875 created "2016-06-24" @default.
- W2012996875 creator A5031637864 @default.
- W2012996875 creator A5069364785 @default.
- W2012996875 date "2013-05-23" @default.
- W2012996875 modified "2023-09-23" @default.
- W2012996875 title "Incretin hormones and beta-cell mass expansion: what we know and what is missing?" @default.
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