FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012998052> ?p ?o ?g. }

• W2012998052 endingPage "C1548" @default.
• W2012998052 startingPage "C1541" @default.
• W2012998052 abstract "Activated arginase has been implicated in many diseases including cancer, immune cell dysfunction, infections, and vascular disease. Enhanced arginase activity has been reported in lungs of patients with pulmonary artery hypertension. We used hypoxia as a model for pulmonary hypertension and studied the effect of exposure to hypoxia on arginase activity in human lung microvascular endothelial cells (HMVEC). Hypoxia induces upregulation of arginase activity as well as mRNA and protein levels of arginase II (Arg II), the only arginase isoform we were able to identify in HMVEC. In endothelial cells, arginase shares and competes for the substrate l-arginine with nitric oxide (NO) synthase (NOS). Through regulation of substrate availability for NOS, arginase is able to modulate NO production. To evaluate the role of Arg II in regulation of NO production under hypoxia, we compared NO output (RFL-6 reporter assay) in cells with normal and silenced Arg II. Exposure to hypoxia led to an increase in NO levels produced by HMVEC. Inhibition of Arg II by specific small interfering RNA or by the pharmacological inhibitor BEC additionally enhanced the levels of NO. Another possible role for activated arginase is involvement in regulation of cell proliferation. However, we showed that hypoxia decreased cell proliferation and upregulated Arg II did not have an effect on cell proliferation. Since hypoxia-inducible factors (HIF) are a family of transcriptional factors activated by hypoxia, we tested the possibility of involvement of HIF-1 and HIF-2 in regulation of Arg II under hypoxia. The silencing of HIF-2 but not HIF-1 prevented the activation of Arg II by hypoxia." @default.
• W2012998052 created "2016-06-24" @default.
• W2012998052 creator A5027621563 @default.
• W2012998052 creator A5040247825 @default.
• W2012998052 creator A5052473240 @default.
• W2012998052 creator A5086158707 @default.
• W2012998052 date "2010-12-01" @default.
• W2012998052 modified "2023-10-17" @default.
• W2012998052 title "Hypoxic upregulation of arginase II in human lung endothelial cells" @default.
• W2012998052 cites W1498251513 @default.
• W2012998052 cites W1581040284 @default.
• W2012998052 cites W1880313810 @default.
• W2012998052 cites W1967251155 @default.
• W2012998052 cites W1969610841 @default.
• W2012998052 cites W1971110044 @default.
• W2012998052 cites W1979346881 @default.
• W2012998052 cites W1981487137 @default.
• W2012998052 cites W1981904619 @default.
• W2012998052 cites W1996295305 @default.
• W2012998052 cites W1996885111 @default.
• W2012998052 cites W2002747013 @default.
• W2012998052 cites W2003106613 @default.
• W2012998052 cites W2005271042 @default.
• W2012998052 cites W2015192504 @default.
• W2012998052 cites W2020818523 @default.
• W2012998052 cites W2070261550 @default.
• W2012998052 cites W2071968903 @default.
• W2012998052 cites W2074507891 @default.
• W2012998052 cites W2086832534 @default.
• W2012998052 cites W2087630739 @default.
• W2012998052 cites W2088114264 @default.
• W2012998052 cites W2090583091 @default.
• W2012998052 cites W2092310649 @default.
• W2012998052 cites W2098866409 @default.
• W2012998052 cites W2104260741 @default.
• W2012998052 cites W2110085982 @default.
• W2012998052 cites W2116905957 @default.
• W2012998052 cites W2117611798 @default.
• W2012998052 cites W2117779825 @default.
• W2012998052 cites W2120705888 @default.
• W2012998052 cites W2120968095 @default.
• W2012998052 cites W2122606436 @default.
• W2012998052 cites W2125031388 @default.
• W2012998052 cites W2129809831 @default.
• W2012998052 cites W2131676053 @default.
• W2012998052 cites W2136895488 @default.
• W2012998052 cites W2136978968 @default.
• W2012998052 cites W2138265026 @default.
• W2012998052 cites W2139722434 @default.
• W2012998052 cites W2140105055 @default.
• W2012998052 cites W2143132042 @default.
• W2012998052 cites W2153058053 @default.
• W2012998052 cites W2153329657 @default.
• W2012998052 cites W2160666161 @default.
• W2012998052 cites W2162826187 @default.
• W2012998052 cites W2170004689 @default.
• W2012998052 cites W2170331970 @default.
• W2012998052 cites W2175672349 @default.
• W2012998052 cites W2280649643 @default.
• W2012998052 cites W2281124822 @default.
• W2012998052 cites W2313158847 @default.
• W2012998052 cites W2419604885 @default.
• W2012998052 cites W37419188 @default.
• W2012998052 cites W4231929280 @default.
• W2012998052 doi "https://doi.org/10.1152/ajpcell.00068.2010" @default.
• W2012998052 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3774096" @default.
• W2012998052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20861464" @default.
• W2012998052 hasPublicationYear "2010" @default.
• W2012998052 type Work @default.
• W2012998052 sameAs 2012998052 @default.
• W2012998052 citedByCount "71" @default.
• W2012998052 countsByYear W20129980522012 @default.
• W2012998052 countsByYear W20129980522013 @default.
• W2012998052 countsByYear W20129980522014 @default.
• W2012998052 countsByYear W20129980522015 @default.
• W2012998052 countsByYear W20129980522016 @default.
• W2012998052 countsByYear W20129980522017 @default.
• W2012998052 countsByYear W20129980522018 @default.
• W2012998052 countsByYear W20129980522019 @default.
• W2012998052 countsByYear W20129980522020 @default.
• W2012998052 countsByYear W20129980522021 @default.
• W2012998052 countsByYear W20129980522022 @default.
• W2012998052 countsByYear W20129980522023 @default.
• W2012998052 crossrefType "journal-article" @default.
• W2012998052 hasAuthorship W2012998052A5027621563 @default.
• W2012998052 hasAuthorship W2012998052A5040247825 @default.
• W2012998052 hasAuthorship W2012998052A5052473240 @default.
• W2012998052 hasAuthorship W2012998052A5086158707 @default.
• W2012998052 hasBestOaLocation W20129980522 @default.
• W2012998052 hasConcept C104317684 @default.
• W2012998052 hasConcept C123012128 @default.
• W2012998052 hasConcept C126322002 @default.
• W2012998052 hasConcept C127561419 @default.
• W2012998052 hasConcept C134018914 @default.
• W2012998052 hasConcept C164007495 @default.
• W2012998052 hasConcept C178790620 @default.
• W2012998052 hasConcept C185592680 @default.
• W2012998052 hasConcept C202751555 @default.

• next