Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012998153> ?p ?o ?g. }
- W2012998153 endingPage "5189" @default.
- W2012998153 startingPage "5185" @default.
- W2012998153 abstract "A series of sulfonamides incorporating cyclic imide moieties were investigated as inhibitors of several human α-carbonic anhydrase (hCA, EC 4.2.1.1) isoforms. Several carboxylic acids possessing the same scaffolds as the sulfonamides were also included in the study, since the sulfonamidate and the carboxylate are among the frequently used zinc-binding groups (ZBGs) for obtaining zinc enzymes inhibitors. The cytosolic isoform hCA I was moderately inhibited by most of the 30 investigated derivatives; many low nanomolar hCA II inhibitors were detected, whereas some of these compounds were low nanomolar/subnanomolar inhibitors of the transmembrane, tumor-associated isoforms hCA IX and XII. In this series of compounds the SO2NH− and the COO− ZBGs showed similar efficacy for obtaining potent inhibitors, although some carboxylates had isoform-selective inhibition profiles for the transmembrane CAs." @default.
- W2012998153 created "2016-06-24" @default.
- W2012998153 creator A5013795495 @default.
- W2012998153 creator A5015328731 @default.
- W2012998153 creator A5018002037 @default.
- W2012998153 creator A5035013697 @default.
- W2012998153 date "2014-11-01" @default.
- W2012998153 modified "2023-09-27" @default.
- W2012998153 title "Carbonic anhydrase inhibitory activity of sulfonamides and carboxylic acids incorporating cyclic imide scaffolds" @default.
- W2012998153 cites W1573899446 @default.
- W2012998153 cites W1969894847 @default.
- W2012998153 cites W1970977423 @default.
- W2012998153 cites W1972547175 @default.
- W2012998153 cites W1975579638 @default.
- W2012998153 cites W1981283595 @default.
- W2012998153 cites W1982970232 @default.
- W2012998153 cites W1984642014 @default.
- W2012998153 cites W1985106162 @default.
- W2012998153 cites W1988107803 @default.
- W2012998153 cites W1989137879 @default.
- W2012998153 cites W1989845430 @default.
- W2012998153 cites W1995078959 @default.
- W2012998153 cites W2002483066 @default.
- W2012998153 cites W2005153032 @default.
- W2012998153 cites W2006291474 @default.
- W2012998153 cites W2011950726 @default.
- W2012998153 cites W2011974303 @default.
- W2012998153 cites W2014210771 @default.
- W2012998153 cites W2017833359 @default.
- W2012998153 cites W2018512578 @default.
- W2012998153 cites W2023858126 @default.
- W2012998153 cites W2025322665 @default.
- W2012998153 cites W2027941054 @default.
- W2012998153 cites W2033235454 @default.
- W2012998153 cites W2035210468 @default.
- W2012998153 cites W2038785143 @default.
- W2012998153 cites W2045751610 @default.
- W2012998153 cites W2047178318 @default.
- W2012998153 cites W2048253776 @default.
- W2012998153 cites W2051349300 @default.
- W2012998153 cites W2054162695 @default.
- W2012998153 cites W2055064482 @default.
- W2012998153 cites W2055787506 @default.
- W2012998153 cites W2058004521 @default.
- W2012998153 cites W2059720379 @default.
- W2012998153 cites W2064520140 @default.
- W2012998153 cites W2066665206 @default.
- W2012998153 cites W2071028997 @default.
- W2012998153 cites W2077687384 @default.
- W2012998153 cites W2080990522 @default.
- W2012998153 cites W2082259677 @default.
- W2012998153 cites W2082283100 @default.
- W2012998153 cites W2089687855 @default.
- W2012998153 cites W2090219807 @default.
- W2012998153 cites W2090897993 @default.
- W2012998153 cites W2100788797 @default.
- W2012998153 cites W2117473646 @default.
- W2012998153 cites W2118720805 @default.
- W2012998153 cites W2125916691 @default.
- W2012998153 cites W2126176617 @default.
- W2012998153 cites W2128102076 @default.
- W2012998153 cites W2131861685 @default.
- W2012998153 cites W2134074055 @default.
- W2012998153 cites W2136299255 @default.
- W2012998153 cites W2150627175 @default.
- W2012998153 cites W2150869840 @default.
- W2012998153 cites W2150994243 @default.
- W2012998153 cites W2165423396 @default.
- W2012998153 cites W4211118618 @default.
- W2012998153 doi "https://doi.org/10.1016/j.bmcl.2014.09.076" @default.
- W2012998153 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25442309" @default.
- W2012998153 hasPublicationYear "2014" @default.
- W2012998153 type Work @default.
- W2012998153 sameAs 2012998153 @default.
- W2012998153 citedByCount "44" @default.
- W2012998153 countsByYear W20129981532015 @default.
- W2012998153 countsByYear W20129981532016 @default.
- W2012998153 countsByYear W20129981532017 @default.
- W2012998153 countsByYear W20129981532018 @default.
- W2012998153 countsByYear W20129981532019 @default.
- W2012998153 countsByYear W20129981532020 @default.
- W2012998153 countsByYear W20129981532021 @default.
- W2012998153 countsByYear W20129981532022 @default.
- W2012998153 countsByYear W20129981532023 @default.
- W2012998153 crossrefType "journal-article" @default.
- W2012998153 hasAuthorship W2012998153A5013795495 @default.
- W2012998153 hasAuthorship W2012998153A5015328731 @default.
- W2012998153 hasAuthorship W2012998153A5018002037 @default.
- W2012998153 hasAuthorship W2012998153A5035013697 @default.
- W2012998153 hasConcept C104317684 @default.
- W2012998153 hasConcept C119795356 @default.
- W2012998153 hasConcept C170493617 @default.
- W2012998153 hasConcept C178790620 @default.
- W2012998153 hasConcept C181199279 @default.
- W2012998153 hasConcept C185592680 @default.
- W2012998153 hasConcept C24530287 @default.
- W2012998153 hasConcept C2775914622 @default.
- W2012998153 hasConcept C2776980637 @default.