FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013012469> ?p ?o ?g. }

• W2013012469 endingPage "e33191" @default.
• W2013012469 startingPage "e33191" @default.
• W2013012469 abstract "N-acetylglucosaminyltransferase-III (GnT-III) is a glycosyltransferase encoded by Mgat3 that catalyzes the addition of β1,4-bisecting-N-acetylglucosamine on N-glycans. GnT-III has been pointed as a metastases suppressor having varying effects on cell adhesion and migration. We have previously described the existence of a functional feedback loop between E-cadherin expression and GnT-III-mediated glycosylation. The effects of GnT-III-mediated glycosylation on E-cadherin expression and cellular phenotype lead us to evaluate Mgat3 and GnT-III-glycosylation role during Epithelial-Mesenchymal-Transition (EMT) and the reverted process, Mesenchymal-Epithelial-Transition (MET).We analyzed the expression profile and genetic mechanism controlling Mgat3 expression as well as GnT-III-mediated glycosylation, in general and specifically on E-cadherin, during EMT/MET. We found that during EMT, Mgat3 expression was dramatically decreased and later recovered when cells returned to an epithelial-like phenotype. We further identified that Mgat3 promoter methylation/demethylation is involved in this expression regulation. The impact of Mgat3 expression variation, along EMT/MET, leads to a variation in the expression levels of the enzymatic product of GnT-III (bisecting GlcNAc structures), and more importantly, to the specific modification of E-cadherin glycosylation with bisecting GlcNAc structures.Altogether, this work identifies for the first time Mgat3 glycogene expression and GnT-III-mediated glycosylation, specifically on E-cadherin, as a novel and major component of the EMT/MET mechanism signature, supporting its role during EMT/MET." @default.
• W2013012469 created "2016-06-24" @default.
• W2013012469 creator A5004539102 @default.
• W2013012469 creator A5038760927 @default.
• W2013012469 creator A5049513875 @default.
• W2013012469 creator A5059554299 @default.
• W2013012469 creator A5062401778 @default.
• W2013012469 creator A5063590526 @default.
• W2013012469 creator A5065205503 @default.
• W2013012469 creator A5085086748 @default.
• W2013012469 creator A5090485090 @default.
• W2013012469 date "2012-03-13" @default.
• W2013012469 modified "2023-09-28" @default.
• W2013012469 title "Loss and Recovery of Mgat3 and GnT-III Mediated E-cadherin N-glycosylation Is a Mechanism Involved in Epithelial-Mesenchymal-Epithelial Transitions" @default.
• W2013012469 cites W1978029329 @default.
• W2013012469 cites W1978679649 @default.
• W2013012469 cites W1986028702 @default.
• W2013012469 cites W1996118868 @default.
• W2013012469 cites W2000572756 @default.
• W2013012469 cites W2004125187 @default.
• W2013012469 cites W2024191848 @default.
• W2013012469 cites W2032507799 @default.
• W2013012469 cites W2045082439 @default.
• W2013012469 cites W2048065251 @default.
• W2013012469 cites W2054882534 @default.
• W2013012469 cites W2057271422 @default.
• W2013012469 cites W2059529313 @default.
• W2013012469 cites W2062136146 @default.
• W2013012469 cites W2076583198 @default.
• W2013012469 cites W2076785665 @default.
• W2013012469 cites W2077462602 @default.
• W2013012469 cites W2082055110 @default.
• W2013012469 cites W2086996769 @default.
• W2013012469 cites W2093889436 @default.
• W2013012469 cites W2096683453 @default.
• W2013012469 cites W2100275703 @default.
• W2013012469 cites W2101121084 @default.
• W2013012469 cites W2107277218 @default.
• W2013012469 cites W2111251470 @default.
• W2013012469 cites W2117692326 @default.
• W2013012469 cites W2140551998 @default.
• W2013012469 cites W2166819109 @default.
• W2013012469 cites W2167979700 @default.
• W2013012469 cites W4210450218 @default.
• W2013012469 doi "https://doi.org/10.1371/journal.pone.0033191" @default.
• W2013012469 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3302839" @default.
• W2013012469 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22427986" @default.
• W2013012469 hasPublicationYear "2012" @default.
• W2013012469 type Work @default.
• W2013012469 sameAs 2013012469 @default.
• W2013012469 citedByCount "92" @default.
• W2013012469 countsByYear W20130124692012 @default.
• W2013012469 countsByYear W20130124692013 @default.
• W2013012469 countsByYear W20130124692014 @default.
• W2013012469 countsByYear W20130124692015 @default.
• W2013012469 countsByYear W20130124692016 @default.
• W2013012469 countsByYear W20130124692017 @default.
• W2013012469 countsByYear W20130124692018 @default.
• W2013012469 countsByYear W20130124692019 @default.
• W2013012469 countsByYear W20130124692020 @default.
• W2013012469 countsByYear W20130124692021 @default.
• W2013012469 countsByYear W20130124692022 @default.
• W2013012469 countsByYear W20130124692023 @default.
• W2013012469 crossrefType "journal-article" @default.
• W2013012469 hasAuthorship W2013012469A5004539102 @default.
• W2013012469 hasAuthorship W2013012469A5038760927 @default.
• W2013012469 hasAuthorship W2013012469A5049513875 @default.
• W2013012469 hasAuthorship W2013012469A5059554299 @default.
• W2013012469 hasAuthorship W2013012469A5062401778 @default.
• W2013012469 hasAuthorship W2013012469A5063590526 @default.
• W2013012469 hasAuthorship W2013012469A5065205503 @default.
• W2013012469 hasAuthorship W2013012469A5085086748 @default.
• W2013012469 hasAuthorship W2013012469A5090485090 @default.
• W2013012469 hasBestOaLocation W20130124691 @default.
• W2013012469 hasConcept C104317684 @default.
• W2013012469 hasConcept C108625454 @default.
• W2013012469 hasConcept C127716648 @default.
• W2013012469 hasConcept C1491633281 @default.
• W2013012469 hasConcept C149402561 @default.
• W2013012469 hasConcept C194232998 @default.
• W2013012469 hasConcept C206212055 @default.
• W2013012469 hasConcept C2777313579 @default.
• W2013012469 hasConcept C30324644 @default.
• W2013012469 hasConcept C54355233 @default.
• W2013012469 hasConcept C76419328 @default.
• W2013012469 hasConcept C86803240 @default.
• W2013012469 hasConcept C95444343 @default.
• W2013012469 hasConceptScore W2013012469C104317684 @default.
• W2013012469 hasConceptScore W2013012469C108625454 @default.
• W2013012469 hasConceptScore W2013012469C127716648 @default.
• W2013012469 hasConceptScore W2013012469C1491633281 @default.
• W2013012469 hasConceptScore W2013012469C149402561 @default.
• W2013012469 hasConceptScore W2013012469C194232998 @default.
• W2013012469 hasConceptScore W2013012469C206212055 @default.
• W2013012469 hasConceptScore W2013012469C2777313579 @default.
• W2013012469 hasConceptScore W2013012469C30324644 @default.
• W2013012469 hasConceptScore W2013012469C54355233 @default.
• W2013012469 hasConceptScore W2013012469C76419328 @default.

• next