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• W2013014265 abstract "L-arginine (L-Arg) deficiency results in decreased T-cell proliferation and impaired T-cell function. Here we have found that L-Arg depletion inhibited expression of different membrane antigens, including CD247 (CD3ζ), and led to an ER stress response, as well as cell cycle arrest at G0/G1 in both human Jurkat and peripheral blood mitogen-activated T cells, without undergoing apoptosis. By genetic and biochemical approaches, we found that L-Arg depletion also induced autophagy. Deprivation of L-Arg induced EIF2S1 (eIF2α), MAPK8 (JNK), BCL2 (Bcl-2) phosphorylation, and displacement of BECN1 (Beclin 1) binding to BCL2, leading to autophagosome formation. Silencing of ERN1 (IRE1α) prevented the induction of autophagy as well as MAPK8 activation, BCL2 phosphorylation and XBP1 splicing, whereas led T lymphocytes to apoptosis under L-Arg starvation, suggesting that the ERN1-MAPK8 pathway plays a major role in the activation of autophagy following L-Arg depletion. Autophagy was required for survival of T lymphocytes in the absence of L-Arg, and resulted in a reversible process. Replenishment of L-Arg made T lymphocytes to regain the normal cell cycle profile and proliferate, whereas autophagy was inhibited. Inhibition of autophagy by ERN1, BECN1 and ATG7 silencing, or by pharmacological inhibitors, promoted cell death of T lymphocytes incubated in the absence of L-Arg. Our data indicate for the first time that depletion of L-Arg in T lymphocytes leads to a reversible response that preserves T lymphocytes through ER stress and autophagy, while remaining arrested at G0/G1. Our data also show that the L-Arg depletion-induced ER stress response could lead to apoptosis when autophagy is blocked." @default.
• W2013014265 created "2016-06-24" @default.
• W2013014265 creator A5035396741 @default.
• W2013014265 creator A5040664837 @default.
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• W2013014265 date "2012-11-09" @default.
• W2013014265 modified "2023-10-03" @default.
• W2013014265 title "Depletion of<scp>L</scp>-arginine induces autophagy as a cytoprotective response to endoplasmic reticulum stress in human T lymphocytes" @default.
• W2013014265 cites W151965417 @default.
• W2013014265 cites W1780295430 @default.
• W2013014265 cites W1905007654 @default.
• W2013014265 cites W1971245158 @default.
• W2013014265 cites W1972336737 @default.
• W2013014265 cites W1976531450 @default.
• W2013014265 cites W1977179270 @default.
• W2013014265 cites W1977767269 @default.
• W2013014265 cites W1978188507 @default.
• W2013014265 cites W1980942517 @default.
• W2013014265 cites W1981551685 @default.
• W2013014265 cites W1989665460 @default.
• W2013014265 cites W1990775595 @default.
• W2013014265 cites W1995910924 @default.
• W2013014265 cites W2000725338 @default.
• W2013014265 cites W2001467419 @default.
• W2013014265 cites W2009174142 @default.
• W2013014265 cites W2009741382 @default.
• W2013014265 cites W2014918593 @default.
• W2013014265 cites W2017813632 @default.
• W2013014265 cites W2021515624 @default.
• W2013014265 cites W2026312959 @default.
• W2013014265 cites W2029605527 @default.
• W2013014265 cites W2039670350 @default.
• W2013014265 cites W2043819590 @default.
• W2013014265 cites W2044241702 @default.
• W2013014265 cites W2045629309 @default.
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• W2013014265 cites W2052034388 @default.
• W2013014265 cites W2054100919 @default.
• W2013014265 cites W2054246680 @default.
• W2013014265 cites W2062918974 @default.
• W2013014265 cites W2065122303 @default.
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• W2013014265 cites W2077670472 @default.
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• W2013014265 cites W2082796078 @default.
• W2013014265 cites W2084952088 @default.
• W2013014265 cites W2086939601 @default.
• W2013014265 cites W2089892162 @default.
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• W2013014265 doi "https://doi.org/10.4161/auto.21315" @default.
• W2013014265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3494587" @default.
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