FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013015384> ?p ?o ?g. }

• W2013015384 endingPage "4392" @default.
• W2013015384 startingPage "4392" @default.
• W2013015384 abstract "purpose. The purpose of the present study was to investigate the roles of caspase 1 and extracellular signal-regulated kinase (ERK) in inflammation-induced inhibition of lacrimal gland secretion. methods. Lacrimal gland inflammation was induced by injection of lipopolysaccharide (LPS; to study the role of caspase 1) or IL-1β (to study the role of ERK). Lacrimal gland protein secretion was measured using a spectrofluorometric assay. Caspase 1 and ERK activities in the lacrimal gland were measured by immunohistochemistry, Western blotting, or both. Aqueous tear production was measured using phenol red–impregnated cotton threads. results. Injection of LPS into the lacrimal gland inhibited neurally and adrenergic agonist–induced protein secretion by 77% and 54%, respectively, and activated caspase 1. The degree of inhibition achieved by LPS was similar to that obtained with injection of IL-1β. Inhibition of caspase 1 alleviated the inhibitory effect of LPS on lacrimal gland secretion. IL-1β activated ERK in the lacrimal gland in vitro and in vivo, and this effect was blocked by UO126, an inhibitor of MEK, the ERK-activating enzyme. IL-1β injection into the lacrimal gland inhibited aqueous tear production by 52% and inhibited neurally and adrenergic agonist-induced protein secretion by 80% and 55%, respectively. UO126 alleviated the inhibitory effect of IL-1β on aqueous tear production and lacrimal gland protein secretion. conclusions. LPS inhibits lacrimal gland secretion by activating caspase 1, and IL-1β activates the ERK pathway to inhibit lacrimal gland protein secretion and aqueous tear production." @default.
• W2013015384 created "2016-06-24" @default.
• W2013015384 creator A5003085763 @default.
• W2013015384 creator A5017775886 @default.
• W2013015384 creator A5056916853 @default.
• W2013015384 creator A5072022072 @default.
• W2013015384 date "2008-10-01" @default.
• W2013015384 modified "2023-10-14" @default.
• W2013015384 title "Roles of Caspase 1 and Extracellular Signal–Regulated Kinase in Inflammation-Induced Inhibition of Lacrimal Gland Protein Secretion" @default.
• W2013015384 cites W127313292 @default.
• W2013015384 cites W136654495 @default.
• W2013015384 cites W1497537116 @default.
• W2013015384 cites W1513505427 @default.
• W2013015384 cites W1515994079 @default.
• W2013015384 cites W1529674879 @default.
• W2013015384 cites W1577987358 @default.
• W2013015384 cites W1973614704 @default.
• W2013015384 cites W1981109162 @default.
• W2013015384 cites W1985897524 @default.
• W2013015384 cites W1997151560 @default.
• W2013015384 cites W2000956978 @default.
• W2013015384 cites W2002283784 @default.
• W2013015384 cites W2004970413 @default.
• W2013015384 cites W2006537168 @default.
• W2013015384 cites W2008261126 @default.
• W2013015384 cites W2009124293 @default.
• W2013015384 cites W2012632172 @default.
• W2013015384 cites W2015494251 @default.
• W2013015384 cites W2031553804 @default.
• W2013015384 cites W2031753589 @default.
• W2013015384 cites W2042087846 @default.
• W2013015384 cites W2042943885 @default.
• W2013015384 cites W2043513023 @default.
• W2013015384 cites W2052895824 @default.
• W2013015384 cites W2065975622 @default.
• W2013015384 cites W2079092923 @default.
• W2013015384 cites W2091821996 @default.
• W2013015384 cites W2108362910 @default.
• W2013015384 cites W2116101489 @default.
• W2013015384 cites W2124600315 @default.
• W2013015384 cites W2170226518 @default.
• W2013015384 cites W596805108 @default.
• W2013015384 doi "https://doi.org/10.1167/iovs.08-1830" @default.
• W2013015384 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2568975" @default.
• W2013015384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18566460" @default.
• W2013015384 hasPublicationYear "2008" @default.
• W2013015384 type Work @default.
• W2013015384 sameAs 2013015384 @default.
• W2013015384 citedByCount "8" @default.
• W2013015384 countsByYear W20130153842012 @default.
• W2013015384 countsByYear W20130153842013 @default.
• W2013015384 countsByYear W20130153842015 @default.
• W2013015384 crossrefType "journal-article" @default.
• W2013015384 hasAuthorship W2013015384A5003085763 @default.
• W2013015384 hasAuthorship W2013015384A5017775886 @default.
• W2013015384 hasAuthorship W2013015384A5056916853 @default.
• W2013015384 hasAuthorship W2013015384A5072022072 @default.
• W2013015384 hasBestOaLocation W20130153842 @default.
• W2013015384 hasConcept C126322002 @default.
• W2013015384 hasConcept C134018914 @default.
• W2013015384 hasConcept C142724271 @default.
• W2013015384 hasConcept C184235292 @default.
• W2013015384 hasConcept C185592680 @default.
• W2013015384 hasConcept C2779298748 @default.
• W2013015384 hasConcept C2780750233 @default.
• W2013015384 hasConcept C28406088 @default.
• W2013015384 hasConcept C49039625 @default.
• W2013015384 hasConcept C57074206 @default.
• W2013015384 hasConcept C71924100 @default.
• W2013015384 hasConcept C86803240 @default.
• W2013015384 hasConcept C95444343 @default.
• W2013015384 hasConcept C97029542 @default.
• W2013015384 hasConceptScore W2013015384C126322002 @default.
• W2013015384 hasConceptScore W2013015384C134018914 @default.
• W2013015384 hasConceptScore W2013015384C142724271 @default.
• W2013015384 hasConceptScore W2013015384C184235292 @default.
• W2013015384 hasConceptScore W2013015384C185592680 @default.
• W2013015384 hasConceptScore W2013015384C2779298748 @default.
• W2013015384 hasConceptScore W2013015384C2780750233 @default.
• W2013015384 hasConceptScore W2013015384C28406088 @default.
• W2013015384 hasConceptScore W2013015384C49039625 @default.
• W2013015384 hasConceptScore W2013015384C57074206 @default.
• W2013015384 hasConceptScore W2013015384C71924100 @default.
• W2013015384 hasConceptScore W2013015384C86803240 @default.
• W2013015384 hasConceptScore W2013015384C95444343 @default.
• W2013015384 hasConceptScore W2013015384C97029542 @default.
• W2013015384 hasIssue "10" @default.
• W2013015384 hasLocation W20130153841 @default.
• W2013015384 hasLocation W20130153842 @default.
• W2013015384 hasLocation W20130153843 @default.
• W2013015384 hasLocation W20130153844 @default.
• W2013015384 hasOpenAccess W2013015384 @default.
• W2013015384 hasPrimaryLocation W20130153841 @default.
• W2013015384 hasRelatedWork W1986836279 @default.
• W2013015384 hasRelatedWork W1999231041 @default.
• W2013015384 hasRelatedWork W2014416267 @default.
• W2013015384 hasRelatedWork W2020884724 @default.
• W2013015384 hasRelatedWork W2083779872 @default.

• next