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- W2013018295 abstract "Cholinergic basal forebrain (BF) neurons source one of the largest modulator systems of the brain, supplying acetylcholine to the entire cerebral mantle. Ample evidence suggests a causal link between the depletion of cortical acetylcholine and the selective disruption of cognitive functions in the course of aging and Alzheimer's disease (AD). A distinctive yet underappreciated feature of BF cholinergic neurons is their enrichment with the p75 neurotrophin receptor (p75(NTR)), which is also recognized as a high-affinity acceptor for the amyloid-β (Aβ) peptide. Herein, we critically overview the emerging data, which suggest the relevance of p75(NTR)-mediated uptake of Aβ followed by its degradation in lysosomes of BF cholinergic neurons for the homeostasis and clearance of this peptide from the cerebral cortex. We propose that via such a unique arrangement, cholinergic neurons afford their functional targets with an efficient molecular drain for Aβ. This process is suggested as the proximal cause for the greater wear and tear of the BF cholinergic system during aging and especially AD." @default.
- W2013018295 created "2016-06-24" @default.
- W2013018295 creator A5036467116 @default.
- W2013018295 creator A5069184646 @default.
- W2013018295 date "2013-11-01" @default.
- W2013018295 modified "2023-09-27" @default.
- W2013018295 title "Drain of the brain: low-affinity p75 neurotrophin receptor affords a molecular sink for clearance of cortical amyloid β by the cholinergic modulator system" @default.
- W2013018295 cites W141830102 @default.
- W2013018295 cites W1483703465 @default.
- W2013018295 cites W1492009115 @default.
- W2013018295 cites W1494415215 @default.
- W2013018295 cites W1502785574 @default.
- W2013018295 cites W1509043648 @default.
- W2013018295 cites W1537234916 @default.
- W2013018295 cites W1572154908 @default.
- W2013018295 cites W1586465707 @default.
- W2013018295 cites W1602771322 @default.
- W2013018295 cites W1623920471 @default.
- W2013018295 cites W1744830941 @default.
- W2013018295 cites W1867921149 @default.
- W2013018295 cites W1932612562 @default.
- W2013018295 cites W1964314802 @default.
- W2013018295 cites W1966314736 @default.
- W2013018295 cites W1967823816 @default.
- W2013018295 cites W1968900405 @default.
- W2013018295 cites W1973026127 @default.
- W2013018295 cites W1974475508 @default.
- W2013018295 cites W1974594322 @default.
- W2013018295 cites W1979233894 @default.
- W2013018295 cites W1979620823 @default.
- W2013018295 cites W1980750700 @default.
- W2013018295 cites W1980825524 @default.
- W2013018295 cites W1990543766 @default.
- W2013018295 cites W1990683357 @default.
- W2013018295 cites W1991435932 @default.
- W2013018295 cites W1995508119 @default.
- W2013018295 cites W1997301424 @default.
- W2013018295 cites W1997822484 @default.
- W2013018295 cites W1998191421 @default.
- W2013018295 cites W1998750669 @default.
- W2013018295 cites W2000533565 @default.
- W2013018295 cites W2000706612 @default.
- W2013018295 cites W2001490949 @default.
- W2013018295 cites W2001498167 @default.
- W2013018295 cites W2001664582 @default.
- W2013018295 cites W2003674452 @default.
- W2013018295 cites W2003733809 @default.
- W2013018295 cites W2005301611 @default.
- W2013018295 cites W2008133833 @default.
- W2013018295 cites W2008941864 @default.
- W2013018295 cites W2012927321 @default.
- W2013018295 cites W2014341627 @default.
- W2013018295 cites W2015752928 @default.
- W2013018295 cites W2016254753 @default.
- W2013018295 cites W2017899473 @default.
- W2013018295 cites W2020426953 @default.
- W2013018295 cites W2027251678 @default.
- W2013018295 cites W2030011352 @default.
- W2013018295 cites W2030508474 @default.
- W2013018295 cites W2037401041 @default.
- W2013018295 cites W2040700314 @default.
- W2013018295 cites W2041108499 @default.
- W2013018295 cites W2043107085 @default.
- W2013018295 cites W2044699444 @default.
- W2013018295 cites W2045548994 @default.
- W2013018295 cites W2046952010 @default.
- W2013018295 cites W2048975745 @default.
- W2013018295 cites W2049100671 @default.
- W2013018295 cites W2051235897 @default.
- W2013018295 cites W2054297131 @default.
- W2013018295 cites W2060351135 @default.
- W2013018295 cites W2063699848 @default.
- W2013018295 cites W2064061995 @default.
- W2013018295 cites W2069479156 @default.
- W2013018295 cites W2071766765 @default.
- W2013018295 cites W2074846656 @default.
- W2013018295 cites W2075240805 @default.
- W2013018295 cites W2075907568 @default.
- W2013018295 cites W2077897416 @default.
- W2013018295 cites W2078790263 @default.
- W2013018295 cites W2081133904 @default.
- W2013018295 cites W2084120977 @default.
- W2013018295 cites W2085435800 @default.
- W2013018295 cites W2089289079 @default.
- W2013018295 cites W2089963291 @default.
- W2013018295 cites W2090434536 @default.
- W2013018295 cites W2092211788 @default.
- W2013018295 cites W2094765619 @default.
- W2013018295 cites W2096410114 @default.
- W2013018295 cites W2097116790 @default.
- W2013018295 cites W2097391583 @default.
- W2013018295 cites W2097631517 @default.
- W2013018295 cites W2097867538 @default.
- W2013018295 cites W2100271408 @default.
- W2013018295 cites W2100922089 @default.
- W2013018295 cites W2101959021 @default.
- W2013018295 cites W2101962018 @default.
- W2013018295 cites W2103139149 @default.