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• W2013018585 endingPage "1317" @default.
• W2013018585 startingPage "1307" @default.
• W2013018585 abstract "The binding of the Ets-1 transcription factor to its target DNA sequence is characterized by a highly unusual conformational change consisting of the unfolding of inhibitory helix 1 (HI-1). To probe the interactions that lead to this unfolding, we performed molecular dynamics simulations of the folded states of apo-Ets-1 and the Ets-1-DNA complex. The simulations showed large differences in correlated motions between helix 4 (H4) and HI-1. In apo-Ets-1, H4 and HI-1 moved in-phase and stabilized each other by hydrogen bonding and macrodipolar interactions, whereas in the DNA-bound state, the motion was out-of-phase, with a disruption of the stabilizing interactions. This change in motion was due to hydrogen-bonding interactions between helix 1 (H1) and the DNA. The dipolar energy between H1 and H4 was modulated by hydrogen bonds between H1 and DNA, and, in accordance with experiments, elimination of the hydrogen bonds increased the stability of HI-1. The simulations confirm that the hydrogen bonds between H1 and DNA act as a conformational switch and show that the presence of DNA is communicated from H1 to H4, destabilizing HI-1. The calculations reveal a critical role for correlated motions at the onset of the DNA-induced unfolding." @default.
• W2013018585 created "2016-06-24" @default.
• W2013018585 creator A5012698288 @default.
• W2013018585 creator A5026736912 @default.
• W2013018585 date "2009-02-01" @default.
• W2013018585 modified "2023-09-23" @default.
• W2013018585 title "Correlated Motions and Interactions at the Onset of the DNA-Induced Partial Unfolding of Ets-1" @default.
• W2013018585 cites W1511331938 @default.
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• W2013018585 cites W1550136826 @default.
• W2013018585 cites W155985007 @default.
• W2013018585 cites W1891403707 @default.
• W2013018585 cites W1967662297 @default.
• W2013018585 cites W1967737979 @default.
• W2013018585 cites W1974069792 @default.
• W2013018585 cites W1976499671 @default.
• W2013018585 cites W1980722147 @default.
• W2013018585 cites W1985173600 @default.
• W2013018585 cites W1985177466 @default.
• W2013018585 cites W1991371921 @default.
• W2013018585 cites W1991794210 @default.
• W2013018585 cites W1996970647 @default.
• W2013018585 cites W2000388754 @default.
• W2013018585 cites W2003240840 @default.
• W2013018585 cites W2010200494 @default.
• W2013018585 cites W2011807123 @default.
• W2013018585 cites W2020379597 @default.
• W2013018585 cites W2020610229 @default.
• W2013018585 cites W2022850571 @default.
• W2013018585 cites W2023529914 @default.
• W2013018585 cites W2025817849 @default.
• W2013018585 cites W2026339550 @default.
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• W2013018585 cites W2033350048 @default.
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• W2013018585 cites W2036004730 @default.
• W2013018585 cites W2038395512 @default.
• W2013018585 cites W2050333027 @default.
• W2013018585 cites W2053002126 @default.
• W2013018585 cites W2056372829 @default.
• W2013018585 cites W2056455937 @default.
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• W2013018585 cites W2062393124 @default.
• W2013018585 cites W2063256813 @default.
• W2013018585 cites W2064017844 @default.
• W2013018585 cites W2076387874 @default.
• W2013018585 cites W2085569207 @default.
• W2013018585 cites W2086634221 @default.
• W2013018585 cites W2087257489 @default.
• W2013018585 cites W2091548699 @default.
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• W2013018585 cites W2131572146 @default.
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• W2013018585 doi "https://doi.org/10.1016/j.bpj.2008.11.019" @default.
• W2013018585 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2717251" @default.
• W2013018585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19217849" @default.
• W2013018585 hasPublicationYear "2009" @default.
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