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• W2013021788 abstract "Fosfomycin has been shown to ameliorate the dose-limiting ototoxicity and nephrotoxicity associated with the antineoplastic agent cis-platinum. Clinical use of fosfomycin in cis-platinum-treated tumor patients critically depends on retaining therapeutic efficacy of cis-platinum while designing modalities to reduce side effects. This study uses two independent assay systems for cell viability and proliferation; we demonstrate that cytocidal activity of cis-platinum against human osteosarcoma cell lines is not affected by various concentrations of fosfomycin up to 0.1 mg/ml in vitro. This suggests that in these cells there is no direct pharmacodynamic interaction of cis-platinum and fosfomycin with respect to mechanisms crucial for tumor kill." @default.
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• W2013021788 date "1991-01-01" @default.
• W2013021788 modified "2023-10-18" @default.
• W2013021788 title "Fosfomycin Does not Reduce Cytostatic Activity of Cis-Platinum Against Human Osteosarcoma Cell Lines in Vitro" @default.
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• W2013021788 doi "https://doi.org/10.3109/08880019109033458" @default.
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