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- W2013031495 abstract "In order to develop 5-pentadeuteroethyl-5-phenyl barbituric acid as an alternative tracer in pharmacokinetic and metabolic studies of phenobarbitone, and to search for possible isotope effects associated with such labelling, we propose a gas chromatographic-mass spectrometry assay for simultaneous measurement of phenobarbitone, p-hydroxyphenobarbitone and their perdeuteroethyl analogues, using [1,3-15N2,2-13C] phenobarbitone as internal standard. These compounds were extracted from plasma (50 μl) or urine (500 μl) and pentylated according to Greeley's method. Linear calibration curves were obtained in the concentration range from 0.5 to 3 μg/ml. The interday precision, mean accuracy and detection limit were 0.77–5.28%, 99.99–100.80% and 0.03–0.05 μg/ml, respectively. Results for plasma and urine concentrations, and pharmacokinetic parameters in humans, are presented to illustrate this method." @default.
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- W2013031495 date "1987-01-01" @default.
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- W2013031495 title "Simultaneous quantitation of phenobarbitone and p-hydroxyphenobarbitone and their perdeuteroethyl analogues in biological fluids by combined gas chromatography-mass spectrometry" @default.
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- W2013031495 doi "https://doi.org/10.1016/0378-4347(87)80185-8" @default.
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