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- W2013031738 abstract "The effects of brief repeated swim stress on the expression of GABAA receptor α1 subunit mRNAs was investigated in the mouse. Adult male mice were exposed to repeated brief (10 min) swim-stress once daily for 7 or 14 days and the levels of GABAA receptor α subunit mRNAs were quantified in the hippocampus 24 h after the last session by Northern analysis. Repeated swim stress for 14 days resulted in a 47.3% ± 6.5 and 39.8% ± 7.6 decrease in the levels of the 4.8 kb and 4.4 kb GABAA receptor α1 subunit mRNAs, respectively. While there was a trend toward a reduction in the level of GABAA receptor α1 subunit mRNAs following 7 days of repeated swim stress, the latter did not reach statistical significance. In contrast, no significant alterations in the levels of glutamic acid decarboxylase or β-actin mRNAs were observed at either time point. The reduction in GABAA receptor α1 subunit mRNAs following repeated swim stress may underlie similar alteration(s) in hippocampal GABAA receptor density previously observed following repeated swim stress." @default.
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- W2013031738 date "1993-05-01" @default.
- W2013031738 modified "2023-09-27" @default.
- W2013031738 title "Repeated swim-stress reduces GABAA receptor α subunit mRNAs in the mouse hippocampus" @default.
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- W2013031738 doi "https://doi.org/10.1016/0169-328x(93)90199-y" @default.
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