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- W2013040468 abstract "This study tested the ability of a nitric oxide synthase inhibitor, Nω-nitro-l-arginine methyl ester (l-NAME), to attenuate behavioral hyperalgesia in a rat model of neuropathic pain [Bennett, G.J. and Xie, Y.-K., Pain, 33 (1988) 87–107]. A mononeuropathy was produced by chronic constriction injury (CCI) of the sciatic nerve. Thermal hyperalgesia was assessed by a reduction of paw withdrawal latency to a noxious heat source. Following CCI, there was significant hyperalgesia in groups of rats treated with d-NAME (n = 7), an inactive isomer of l-NAME, saline (n = 7) or systemic l-NAME (n = 10). In contrast, when l-NAME was applied directly and continuously to the site of CCI (5.0 μg/μl per h for up to 2 weeks) via an osmotic pump implanted at the time of the injury, no significant thermal hyperalgesia was observed (n = 8). The results suggest the involvement of nitric oxide in the development and maintenance of thermal hyperalgesia in a rat model of neuropathy. The blockade of nitric oxide production at the site of injury may provide a new approach for treatment of neuropathic pain." @default.
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- W2013040468 title "Application of nitric oxide synthase inhibitor, Nω-nitro-l-arginine methyl ester, on injured nerve attenuates neuropathy-induced thermal hyperalgesia in rats" @default.
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- W2013040468 doi "https://doi.org/10.1016/0304-3940(96)12670-7" @default.
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