FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013042395> ?p ?o ?g. }

• W2013042395 endingPage "31" @default.
• W2013042395 startingPage "24" @default.
• W2013042395 abstract "Goldfish tolerate prolonged and severe hypoxia, thus representing a well-suited model to study the maintenance of cardiac function when O(2) availability represents a limiting factor. Using a working heart preparation, we explored the role of the intracardiac nitric oxide synthase (NOS)-derived nitric oxide (NO) under normoxic and hypoxic conditions. Cardiac performance was examined both under basal (constant preload and afterload) and loading conditions, i.e. preload-induced increases in stroke volume (SV) and hence cardiac output at constant afterload (the Frank-Starling response). Hypoxic hearts showed an increased basal mechanical performance compared to the normoxic counterpart. Under basal conditions, in both normoxic and hypoxic hearts, NOS and soluble guanylyl cyclase (sGC) inhibition increased SV, while exogenous NO supply decreased it. The normoxic heart was very sensitive to filling pressure increases; the maximum SV = 1.08 ± 0.09 mL/kg body mass was obtained at 0.4 kPa. Acute hypoxia increased this sensitivity, SV reaching the maximum value (1.45 ± 0.12 mL/kg body mass) at 0.25 kPa. NOS inhibition by L-NMMA reduced the Frank-Starling response under normoxia, but was ineffective under acute hypoxia, where NO may come from nitrite reduction. In both conditions, sGC inhibition induced a reduction of the cardiac response to preload. Moreover, under acute hypoxia, NO scavenging significantly reduced the Frank-Starling response. The hypoxia-induced hemodynamic patterns were complemented by Western blotting analysis which revealed increased expressions of NOS and hypoxia inducible factor α(HIF-1α). In conclusion, we demonstrated that intracardiac NO/NOS enhances goldfish heart performance, remarkably expanding its hypoxic tolerance." @default.
• W2013042395 created "2016-06-24" @default.
• W2013042395 creator A5006345146 @default.
• W2013042395 creator A5035634112 @default.
• W2013042395 creator A5070555095 @default.
• W2013042395 creator A5088751376 @default.
• W2013042395 date "2014-11-01" @default.
• W2013042395 modified "2023-09-27" @default.
• W2013042395 title "Nitric oxide improves the hemodynamic performance of the hypoxic goldfish (Carassius auratus) heart" @default.
• W2013042395 cites W1511302815 @default.
• W2013042395 cites W1519472981 @default.
• W2013042395 cites W1531734841 @default.
• W2013042395 cites W1906171535 @default.
• W2013042395 cites W1970896711 @default.
• W2013042395 cites W1973223116 @default.
• W2013042395 cites W1975297543 @default.
• W2013042395 cites W1977866515 @default.
• W2013042395 cites W1979109267 @default.
• W2013042395 cites W1985180518 @default.
• W2013042395 cites W1986236472 @default.
• W2013042395 cites W1986470223 @default.
• W2013042395 cites W1987810838 @default.
• W2013042395 cites W1993078436 @default.
• W2013042395 cites W1995314262 @default.
• W2013042395 cites W1999197334 @default.
• W2013042395 cites W2003397264 @default.
• W2013042395 cites W2007472328 @default.
• W2013042395 cites W2009579131 @default.
• W2013042395 cites W2013955380 @default.
• W2013042395 cites W2014934108 @default.
• W2013042395 cites W2016070992 @default.
• W2013042395 cites W2021777909 @default.
• W2013042395 cites W2023318071 @default.
• W2013042395 cites W2024487462 @default.
• W2013042395 cites W2026117623 @default.
• W2013042395 cites W2033780408 @default.
• W2013042395 cites W2051630798 @default.
• W2013042395 cites W2052749560 @default.
• W2013042395 cites W2054497994 @default.
• W2013042395 cites W2055902411 @default.
• W2013042395 cites W2058162461 @default.
• W2013042395 cites W2058667701 @default.
• W2013042395 cites W2060055890 @default.
• W2013042395 cites W2061853558 @default.
• W2013042395 cites W2063660893 @default.
• W2013042395 cites W2069388102 @default.
• W2013042395 cites W2070584691 @default.
• W2013042395 cites W2076853895 @default.
• W2013042395 cites W2079593379 @default.
• W2013042395 cites W2082636978 @default.
• W2013042395 cites W2085022339 @default.
• W2013042395 cites W2089515735 @default.
• W2013042395 cites W2096118264 @default.
• W2013042395 cites W2098349464 @default.
• W2013042395 cites W2104194825 @default.
• W2013042395 cites W2104762462 @default.
• W2013042395 cites W2113299996 @default.
• W2013042395 cites W2113690364 @default.
• W2013042395 cites W2117631539 @default.
• W2013042395 cites W2120861925 @default.
• W2013042395 cites W2122902308 @default.
• W2013042395 cites W2136131273 @default.
• W2013042395 cites W2139577845 @default.
• W2013042395 cites W2139921047 @default.
• W2013042395 cites W2142504123 @default.
• W2013042395 cites W2170317646 @default.
• W2013042395 cites W2170735341 @default.
• W2013042395 cites W2171786063 @default.
• W2013042395 cites W2318125676 @default.
• W2013042395 cites W2340580115 @default.
• W2013042395 cites W4240550661 @default.
• W2013042395 doi "https://doi.org/10.1016/j.niox.2014.08.012" @default.
• W2013042395 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25178168" @default.
• W2013042395 hasPublicationYear "2014" @default.
• W2013042395 type Work @default.
• W2013042395 sameAs 2013042395 @default.
• W2013042395 citedByCount "31" @default.
• W2013042395 countsByYear W20130423952015 @default.
• W2013042395 countsByYear W20130423952016 @default.
• W2013042395 countsByYear W20130423952017 @default.
• W2013042395 countsByYear W20130423952018 @default.
• W2013042395 countsByYear W20130423952019 @default.
• W2013042395 countsByYear W20130423952020 @default.
• W2013042395 countsByYear W20130423952021 @default.
• W2013042395 countsByYear W20130423952022 @default.
• W2013042395 countsByYear W20130423952023 @default.
• W2013042395 crossrefType "journal-article" @default.
• W2013042395 hasAuthorship W2013042395A5006345146 @default.
• W2013042395 hasAuthorship W2013042395A5035634112 @default.
• W2013042395 hasAuthorship W2013042395A5070555095 @default.
• W2013042395 hasAuthorship W2013042395A5088751376 @default.
• W2013042395 hasConcept C123576724 @default.
• W2013042395 hasConcept C126322002 @default.
• W2013042395 hasConcept C134018914 @default.
• W2013042395 hasConcept C139940330 @default.
• W2013042395 hasConcept C164705383 @default.
• W2013042395 hasConcept C178790620 @default.
• W2013042395 hasConcept C178853913 @default.

• next