FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013048452> ?p ?o ?g. }

• W2013048452 endingPage "787" @default.
• W2013048452 startingPage "783" @default.
• W2013048452 abstract "To examine the traditional view that unawareness of hypoglycaemia and inadequate hypoglycaemic counterregulation in insulin dependent diabetes mellitus are manifestations of autonomic neuropathy.Perspective assessment of unawareness of hypoglycaemia and detailed assessment of autonomic neuropathy in patients with insulin dependent diabetes according to the adequacy of their hypoglycaemic counterregulation.One routine diabetic unit in a university teaching hospital.23 Patients aged 21-52 with insulin dependent diabetes mellitus (seven with symptoms suggesting autonomic neuropathy, nine with a serious clinical problem with hypoglycaemia, and seven without symptoms of autonomic neuropathy and without problems with hypoglycaemia) and 10 controls with a similar age distribution, without a personal or family history of diabetes.Presence of autonomic neuropathy as assessed with a test of the longest sympathetic fibres (acetylcholine sweatspot test), a pupil test, and a battery of seven cardiovascular autonomic function tests; adequacy of hypoglycaemic glucose counterregulation during a 40 mU/kg/h insulin infusion test; history of unawareness of hypoglycaemia; and response of plasma pancreatic polypeptide during hypoglycaemia, which depends on an intact and responding autonomic innervation of the pancreas.There was little evidence of autonomic neuropathy in either the 12 diabetic patients with a history of unawareness of hypoglycaemia or the seven patients with inadequate hypoglycaemic counterregulation. By contrast, in all seven patients with clear evidence of autonomic neuropathy there was no history of unawareness of hypoglycaemia and in six out of seven there was adequate hypoglycaemic counterregulation. Unawareness of hypoglycaemia and inadequate hypoglycaemic counterregulation were significantly associated (p less than 0.01). The response of plasma pancreatic polypeptide in the diabetic patients with adequate counterregulation but without autonomic neuropathy was not significantly different from that of the controls (change in plasma pancreatic polypeptide 226.8 v 414 pmol/l). The patients with autonomic neuropathy had a negligible plasma pancreatic polypeptide response (3.7 pmol/l), but this response was also blunted in the patients with inadequate hypoglycaemic counterregulation (72.4 pmol/l) compared with that of the controls (p less than 0.05).Unawareness of hypoglycaemia and inadequate glucose counterregulation during hypoglycaemia are related to each other but are not due to autonomic neuropathy. The blunted plasma pancreatic polypeptide responses of the patients with inadequate hypoglycaemic counterregulation may reflect diminished autonomic activity consequent upon reduced responsiveness of a central glucoregulatory centre, rather than classical autonomic neuropathy." @default.
• W2013048452 created "2016-06-24" @default.
• W2013048452 creator A5003828544 @default.
• W2013048452 creator A5009969006 @default.
• W2013048452 creator A5026209102 @default.
• W2013048452 creator A5061251734 @default.
• W2013048452 creator A5078134786 @default.
• W2013048452 date "1990-10-06" @default.
• W2013048452 modified "2023-10-16" @default.
• W2013048452 title "Unawareness of hypoglycaemia and inadequate hypoglycaemic counterregulation: no causal relation with diabetic autonomic neuropathy." @default.
• W2013048452 cites W1969842414 @default.
• W2013048452 cites W1972233039 @default.
• W2013048452 cites W1979983267 @default.
• W2013048452 cites W1982450798 @default.
• W2013048452 cites W1983019815 @default.
• W2013048452 cites W1993798042 @default.
• W2013048452 cites W1995053301 @default.
• W2013048452 cites W1999614239 @default.
• W2013048452 cites W2009599718 @default.
• W2013048452 cites W2016404753 @default.
• W2013048452 cites W2019361776 @default.
• W2013048452 cites W2025374971 @default.
• W2013048452 cites W2029037252 @default.
• W2013048452 cites W2030026928 @default.
• W2013048452 cites W2032622596 @default.
• W2013048452 cites W2034391708 @default.
• W2013048452 cites W2039265716 @default.
• W2013048452 cites W2055545788 @default.
• W2013048452 cites W2072967422 @default.
• W2013048452 cites W2096864044 @default.
• W2013048452 cites W2104564587 @default.
• W2013048452 cites W2104785771 @default.
• W2013048452 cites W2124111875 @default.
• W2013048452 cites W2134244652 @default.
• W2013048452 cites W2318127375 @default.
• W2013048452 cites W2324213779 @default.
• W2013048452 cites W2325417703 @default.
• W2013048452 cites W2329018285 @default.
• W2013048452 cites W2339035787 @default.
• W2013048452 cites W4300815799 @default.
• W2013048452 doi "https://doi.org/10.1136/bmj.301.6755.783" @default.
• W2013048452 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1663909" @default.
• W2013048452 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2224265" @default.
• W2013048452 hasPublicationYear "1990" @default.
• W2013048452 type Work @default.
• W2013048452 sameAs 2013048452 @default.
• W2013048452 citedByCount "97" @default.
• W2013048452 countsByYear W20130484522012 @default.
• W2013048452 countsByYear W20130484522013 @default.
• W2013048452 countsByYear W20130484522014 @default.
• W2013048452 countsByYear W20130484522015 @default.
• W2013048452 countsByYear W20130484522018 @default.
• W2013048452 countsByYear W20130484522020 @default.
• W2013048452 countsByYear W20130484522022 @default.
• W2013048452 countsByYear W20130484522023 @default.
• W2013048452 crossrefType "journal-article" @default.
• W2013048452 hasAuthorship W2013048452A5003828544 @default.
• W2013048452 hasAuthorship W2013048452A5009969006 @default.
• W2013048452 hasAuthorship W2013048452A5026209102 @default.
• W2013048452 hasAuthorship W2013048452A5061251734 @default.
• W2013048452 hasAuthorship W2013048452A5078134786 @default.
• W2013048452 hasBestOaLocation W20130484521 @default.
• W2013048452 hasConcept C126322002 @default.
• W2013048452 hasConcept C134018914 @default.
• W2013048452 hasConcept C2776715637 @default.
• W2013048452 hasConcept C2777372248 @default.
• W2013048452 hasConcept C2777480322 @default.
• W2013048452 hasConcept C2777953023 @default.
• W2013048452 hasConcept C2779178840 @default.
• W2013048452 hasConcept C2779306644 @default.
• W2013048452 hasConcept C2780668416 @default.
• W2013048452 hasConcept C2781177144 @default.
• W2013048452 hasConcept C2781179581 @default.
• W2013048452 hasConcept C2993505656 @default.
• W2013048452 hasConcept C54355233 @default.
• W2013048452 hasConcept C555293320 @default.
• W2013048452 hasConcept C71635504 @default.
• W2013048452 hasConcept C71924100 @default.
• W2013048452 hasConcept C73787029 @default.
• W2013048452 hasConcept C81885089 @default.
• W2013048452 hasConcept C84393581 @default.
• W2013048452 hasConcept C86803240 @default.
• W2013048452 hasConceptScore W2013048452C126322002 @default.
• W2013048452 hasConceptScore W2013048452C134018914 @default.
• W2013048452 hasConceptScore W2013048452C2776715637 @default.
• W2013048452 hasConceptScore W2013048452C2777372248 @default.
• W2013048452 hasConceptScore W2013048452C2777480322 @default.
• W2013048452 hasConceptScore W2013048452C2777953023 @default.
• W2013048452 hasConceptScore W2013048452C2779178840 @default.
• W2013048452 hasConceptScore W2013048452C2779306644 @default.
• W2013048452 hasConceptScore W2013048452C2780668416 @default.
• W2013048452 hasConceptScore W2013048452C2781177144 @default.
• W2013048452 hasConceptScore W2013048452C2781179581 @default.
• W2013048452 hasConceptScore W2013048452C2993505656 @default.
• W2013048452 hasConceptScore W2013048452C54355233 @default.
• W2013048452 hasConceptScore W2013048452C555293320 @default.
• W2013048452 hasConceptScore W2013048452C71635504 @default.
• W2013048452 hasConceptScore W2013048452C71924100 @default.

• next