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• W2013048589 abstract "Recent studies indicate that interleukin 8 (IL-8) plays an important role in interstitial lung diseases including silica-induced lung inflammation. To investigate the regulation of IL-8 expression and production in human bronchial epithelial cells, we examined the effects of silica on NF-kappaB activation. Human bronchial epithelial cell line BET-1A was cultured with hormonally defined Ham's F12 medium. The administration of silica induced IL-8 production in BET-1A dose-dependently and time-dependently. Northern blot analysis demonstrated that silica upregulated IL-8 expression in BET-1A. Moreover, electrophoretic mobility shift assays revealed that NF-kappaB activation occurred in the presence of silica, which was inhibited by antioxidants such as N-acetylcysteine (NAC). These data suggest that reactive oxygen species may be involved in the activation of NF-kappaB induced by silica." @default.
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• W2013048589 date "2000-08-01" @default.
• W2013048589 modified "2023-10-17" @default.
• W2013048589 title "NUCLEAR FACTOR-KAPPA B ACTIVATION IN SILICA-INDUCED INTERLEUKIN 8 PRODUCTION BY HUMAN BRONCHIAL EPITHELIAL CELLS" @default.
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• W2013048589 doi "https://doi.org/10.1006/cyto.2000.0704" @default.
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