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• W2013051750 endingPage "285" @default.
• W2013051750 startingPage "277" @default.
• W2013051750 abstract "Latent HIV persists in CD4+ T cells in infected patients under antiretroviral therapy (ART). Latency is associated with transcriptional silencing of the integrated provirus and driven, at least in part, by histone deacetylases (HDACs), a family of chromatin-associated proteins that regulate histone acetylation and the accessibility of DNA to transcription factors. Remarkably, inhibition of HDACs is sufficient to reactivate a fraction of latent HIV in a variety of experimental systems. This basic observation led to the shock and kill idea that forcing the transcriptional activation of HIV might lead to virus expression, to virus- or host-induced cell death of the reactivated cells, and to the eradication of the pool of latently infected cells. Such intervention might possibly lead to a cure for HIV-infected patients. Here, we review the basic biology of HDACs and their inhibitors, the role of HDACs in HIV latency, and recent efforts to use HDAC inhibitors to reactivate latent HIV in vitro and in vivo. Latent HIV persists in CD4+ T cells in infected patients under antiretroviral therapy (ART). Latency is associated with transcriptional silencing of the integrated provirus and driven, at least in part, by histone deacetylases (HDACs), a family of chromatin-associated proteins that regulate histone acetylation and the accessibility of DNA to transcription factors. Remarkably, inhibition of HDACs is sufficient to reactivate a fraction of latent HIV in a variety of experimental systems. This basic observation led to the shock and kill idea that forcing the transcriptional activation of HIV might lead to virus expression, to virus- or host-induced cell death of the reactivated cells, and to the eradication of the pool of latently infected cells. Such intervention might possibly lead to a cure for HIV-infected patients. Here, we review the basic biology of HDACs and their inhibitors, the role of HDACs in HIV latency, and recent efforts to use HDAC inhibitors to reactivate latent HIV in vitro and in vivo." @default.
• W2013051750 created "2016-06-24" @default.
• W2013051750 creator A5021154085 @default.
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• W2013051750 creator A5038217290 @default.
• W2013051750 creator A5064776433 @default.
• W2013051750 creator A5067975379 @default.
• W2013051750 date "2013-06-01" @default.
• W2013051750 modified "2023-10-17" @default.
• W2013051750 title "Reactivation of latent HIV by histone deacetylase inhibitors" @default.
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• W2013051750 doi "https://doi.org/10.1016/j.tim.2013.02.005" @default.
• W2013051750 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3685471" @default.
• W2013051750 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23517573" @default.
• W2013051750 hasPublicationYear "2013" @default.
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