Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013059340> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2013059340 endingPage "44" @default.
- W2013059340 startingPage "33" @default.
- W2013059340 abstract "Genetic control of mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) was studied in a set of isogenic yeast strains carrying null or point mutations in DNA repair and replication genes. Null alleles of the PMS1, RAD6, REV3 and RAD52 genes did not affect HAP mutagenesis. Defects in 3'- > 5' exonucleases associated with DNA polymerases epsilon and delta led to 2- to 3-fold increases in HAP-induced forward Can(r) mutant frequency. A similar increase was observed for FOAr mutants but only in the strain with a defective exonuclease of the polymerase epsilon (mutation pol2-4). The polymerase epsilon mutations, pol2-9 and pol2-18, which lead to temperature-sensitivity, and pol2-1 (insertion of URA3 at the position coding for amino acid 1134 in the POL2 gene) substantially reduced HAP mutagenesis. The polymerase delta mutation, cdc2-2, slightly reduced HAP mutagenesis. Enhanced proofreading was not the cause of the antimutator effect in the pol2-18 bearing strain, inasmuch as antimutator effect was observed in the pol2-4,18 mutant strain lacking proofreading. From the data obtained, we conclude that both DNA polymerase epsilon and delta participate in mutation generation by HAP." @default.
- W2013059340 created "2016-06-24" @default.
- W2013059340 creator A5008068827 @default.
- W2013059340 creator A5060879572 @default.
- W2013059340 creator A5067586153 @default.
- W2013059340 creator A5079186468 @default.
- W2013059340 date "1996-07-01" @default.
- W2013059340 modified "2023-10-06" @default.
- W2013059340 title "Base analog 6-N-hydroxylaminopurine mutagenesis in the yeast Saccharomyces cerevisiae is controlled by replicative DNA polymerases" @default.
- W2013059340 cites W1447147799 @default.
- W2013059340 cites W1524319516 @default.
- W2013059340 cites W1570013152 @default.
- W2013059340 cites W1667522964 @default.
- W2013059340 cites W1848529922 @default.
- W2013059340 cites W1900509644 @default.
- W2013059340 cites W1949047146 @default.
- W2013059340 cites W1964314036 @default.
- W2013059340 cites W1965072222 @default.
- W2013059340 cites W1973782344 @default.
- W2013059340 cites W1979699887 @default.
- W2013059340 cites W1980931313 @default.
- W2013059340 cites W1993654107 @default.
- W2013059340 cites W1994955023 @default.
- W2013059340 cites W2000008380 @default.
- W2013059340 cites W2011026782 @default.
- W2013059340 cites W2013648875 @default.
- W2013059340 cites W2023218302 @default.
- W2013059340 cites W2026036824 @default.
- W2013059340 cites W2057809835 @default.
- W2013059340 cites W2061411740 @default.
- W2013059340 cites W206882731 @default.
- W2013059340 cites W2086660631 @default.
- W2013059340 cites W2120902002 @default.
- W2013059340 cites W2126830955 @default.
- W2013059340 cites W2136238750 @default.
- W2013059340 cites W2138476183 @default.
- W2013059340 cites W2328197890 @default.
- W2013059340 cites W61650054 @default.
- W2013059340 doi "https://doi.org/10.1016/s0165-1218(96)90045-2" @default.
- W2013059340 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8700180" @default.
- W2013059340 hasPublicationYear "1996" @default.
- W2013059340 type Work @default.
- W2013059340 sameAs 2013059340 @default.
- W2013059340 citedByCount "48" @default.
- W2013059340 countsByYear W20130593402012 @default.
- W2013059340 countsByYear W20130593402013 @default.
- W2013059340 countsByYear W20130593402015 @default.
- W2013059340 countsByYear W20130593402016 @default.
- W2013059340 countsByYear W20130593402017 @default.
- W2013059340 countsByYear W20130593402019 @default.
- W2013059340 countsByYear W20130593402020 @default.
- W2013059340 crossrefType "journal-article" @default.
- W2013059340 hasAuthorship W2013059340A5008068827 @default.
- W2013059340 hasAuthorship W2013059340A5060879572 @default.
- W2013059340 hasAuthorship W2013059340A5067586153 @default.
- W2013059340 hasAuthorship W2013059340A5079186468 @default.
- W2013059340 hasConcept C104317684 @default.
- W2013059340 hasConcept C143065580 @default.
- W2013059340 hasConcept C153911025 @default.
- W2013059340 hasConcept C16318435 @default.
- W2013059340 hasConcept C170748874 @default.
- W2013059340 hasConcept C176944494 @default.
- W2013059340 hasConcept C2756471 @default.
- W2013059340 hasConcept C54355233 @default.
- W2013059340 hasConcept C73573662 @default.
- W2013059340 hasConcept C82381507 @default.
- W2013059340 hasConcept C86803240 @default.
- W2013059340 hasConceptScore W2013059340C104317684 @default.
- W2013059340 hasConceptScore W2013059340C143065580 @default.
- W2013059340 hasConceptScore W2013059340C153911025 @default.
- W2013059340 hasConceptScore W2013059340C16318435 @default.
- W2013059340 hasConceptScore W2013059340C170748874 @default.
- W2013059340 hasConceptScore W2013059340C176944494 @default.
- W2013059340 hasConceptScore W2013059340C2756471 @default.
- W2013059340 hasConceptScore W2013059340C54355233 @default.
- W2013059340 hasConceptScore W2013059340C73573662 @default.
- W2013059340 hasConceptScore W2013059340C82381507 @default.
- W2013059340 hasConceptScore W2013059340C86803240 @default.
- W2013059340 hasIssue "1-2" @default.
- W2013059340 hasLocation W20130593401 @default.
- W2013059340 hasLocation W20130593402 @default.
- W2013059340 hasOpenAccess W2013059340 @default.
- W2013059340 hasPrimaryLocation W20130593401 @default.
- W2013059340 hasRelatedWork W1936051282 @default.
- W2013059340 hasRelatedWork W1972765689 @default.
- W2013059340 hasRelatedWork W2000232541 @default.
- W2013059340 hasRelatedWork W2031882707 @default.
- W2013059340 hasRelatedWork W2074011169 @default.
- W2013059340 hasRelatedWork W2076445634 @default.
- W2013059340 hasRelatedWork W2077167296 @default.
- W2013059340 hasRelatedWork W2112797008 @default.
- W2013059340 hasRelatedWork W2624814344 @default.
- W2013059340 hasRelatedWork W2398277866 @default.
- W2013059340 hasVolume "369" @default.
- W2013059340 isParatext "false" @default.
- W2013059340 isRetracted "false" @default.
- W2013059340 magId "2013059340" @default.
- W2013059340 workType "article" @default.