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• W2013060215 abstract "To evaluate the influence of left ventricular chamber stiffness and relaxation on Doppler echocardiographic indexes of diastolic function, 35 patients (mean age 60 ± 12 years) were examined; 24 had coronary artery disease and 11 (Group I) had no cardiovascular disease. Micromanometer left ventricular pressure was recorded simultaneously with Doppler echocardiograms of mitral valve inflow and M-mode echocardiograms of left ventricular diameter. The chamber stiffness constant (k) was derived from the pressure-diameter relation. Relaxation was assessed by the isovolumic relaxation time constant (τ) derived from the exponential left ventricular pressure decay. The patients with coronary artery disease were classified into two groups on the basis of complete (Group II; n = 10) and incomplete (Group III; n = 14) relaxation. In Group I (no coronary disease), significant correlations were demonstrated between the chamber stiffness constant and the peak early filling velocity (r = 0.73; p < 0.02), peak early to atrial filling velocity ratio (r = 0.82; p < 0.005), atrial time-velocity integral (r = −0.73; p < 0.02), early to atrial time-velocity integral ratio (r = 0.70; p < 0.05), percent atrial contribution to filling (r = −0.64; p < 0.05) and one-half filling fraction (r = 0.73; p < 0.02). In Group II (coronary disease with complete relaxation), the chamber stiffness constant correlated with peak early filling velocity (r = 0.68; p < 0.05), early filling time-velocity integral (r = 0.65; p < 0.05) and early to atrial time-velocity integral ratio (r = 0.74; p < 0.02). No correlations between k and Doppler indexes were found in Group III (coronary disease with incomplete relaxation). However, Group III demonstrated significant correlations between T and the peak early filling velocity (r = −0.71; p < 0.005), percent atria] contribution to filling (r = 0.56; p < 0.05) and mean acceleration rate of early filling (r = −0.79; p < 0.002). Thus, in subjects with normal relaxation, increasing chamber stiffness was associated with an enhanced peak early filling velocity and volume and decreased filling during atrial systole. This finding differs strikingly from the proposed influence of chamber stiffness on diastolic filling postulated by several researchers. Increasing impairment in relaxation correlated with a decreased peak velocity and mean acceleration rate of early filling and increased atrial contribution to filling. Chamber stiffness and relaxation have contrasting influences on the pattern of diastolic filling as assessed by pulsed Doppler echocardiography." @default.
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• W2013060215 date "1989-02-01" @default.
• W2013060215 modified "2023-10-10" @default.
• W2013060215 title "Left ventricular diastolic function: Comparison of pulsed doppler echocardiographic and hemodynamic indexes in subjects with and without coronary artery disease" @default.
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• W2013060215 doi "https://doi.org/10.1016/0735-1097(89)90507-x" @default.
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