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• W2013060223 abstract "Recent reports have indicated that monosomy 3 is a marker of poor prognosis in uveal melanoma. Fluorescence in situ hybridization (FISH) was performed on fresh touch preparations from 17 uveal, and 5 conjunctival melanomas, using the chromosome 3 centromeric probe, D3Z1. Of the 17 uveal melanomas, all of which originated in the choroid, two cases revealed a monosomy of chromosome 3. One of the conjunctival melanomas contained a major clone that was trisomic for chromosome 3, and another conjunctival melanoma contained a tetrasomic population. FISH, using the α-satellite probe for chromosome 3 on uveal melanoma imprints, allows one to predict which patients are potentially at a higher risk of relapse. Multiplication, ruther than deletion, of copies of chromosome 3 in conjunctival melanomas may be a nonspecific aberration, perhaps indicative of polyploidy, a characteristic of tumor progression." @default.
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• W2013060223 date "1997-10-01" @default.
• W2013060223 modified "2023-10-16" @default.
• W2013060223 title "Assessment of chromosome 3 copy number in ocular melanoma using fluorescence in situ hybridization" @default.
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• W2013060223 doi "https://doi.org/10.1016/s0165-4608(96)00405-0" @default.
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