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• W2013060360 abstract "Apoptosis is a form of cell death, which, until recently, has attracted little interest. However, during the last decade, the number of papers being written concerning apoptosis has increased more rapidly than in any other biomedical field. Currently, apoptosis and programmed cell death (PCD) are probably the most studied phenomena in cellular biology. This intense research focus follows from the increasing understanding that apoptosis represents a major regulatory mechanism in embryonal development, growth and differentiation, as well as in normal tissue homeostasis [1,2]. Whereas apoptosis is a critical mode of cell deletion in normal organism development, apoptotic cells are also observed in tumours, especially following cytotoxic treatments. In the field of cancer therapy, PCD serves as one of the pleiotropic mechanisms of cell-kill by radiation ([3] and references therein), chemical agents [4,5], cytokines [6], hormonal withdrawal in sensitive tissues [7,8] and heat [9]. In their seminal paper, Kerr et al. [2] coined the term 'apoptosis' to describe the specific morphological changes associated with cell death that was quite distinct from necrosis. The term is derived from the Greek apo-ptosis, which describes the process of the 'falling-off' of flowers or leaves from trees, and is used to reflect the physiological nature of this type of death. The authors' conclusion that apoptosis was associated with both physiological and pathological cell death was extremely significant because it raised the possibility that the response might be as general a response as cellular proliferation and differentiation. The vast majority of work conducted on the factors that influence tumour growth and progression have emphasized the role played by enhanced cellular proliferation, but relatively little research had been performed to elucidate the mechanisms involved in cell death. An important factor that is likely to have influenced this state of affairs is the difficulty associated with the study of a phenomenon whose end-point is disappearance. Over a quarter of a century ago, Steel [10] described how cell loss can" @default.
• W2013060360 created "2016-06-24" @default.
• W2013060360 creator A5079281059 @default.
• W2013060360 date "1998-01-01" @default.
• W2013060360 modified "2023-10-16" @default.
• W2013060360 title "Radiation-induced apoptosis" @default.
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• W2013060360 doi "https://doi.org/10.1016/s0936-6555(98)80104-0" @default.
• W2013060360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9543608" @default.
• W2013060360 hasPublicationYear "1998" @default.
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