Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013060770> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2013060770 endingPage "251" @default.
- W2013060770 startingPage "245" @default.
- W2013060770 abstract "Using the major rat allergen as a model has made it possible to study both natural exposure and the human immune response to an important laboratory animal. The close correlation between positive skin tests to whole rat urine and IgE antibody to the major urinary allergen in this and previous studies supports the use of this protein as a model rat allergen. Measurements of airborne rat allergen confirm that the maximum levels are higher than those reported with pollen or mite allergens. However, it is possible that exposure to rat allergens is comparable to levels of exposure to cat salivary allergens in houses with cats. The clear implication is that the high levels of exposure are responsible for the fact that a large proportion of exposed individuals develop IgG antibodies. Our results suggest that the prevalence of IgG antibodies (not individual levels) in a group of workers would be a good guide to exposure. This leaves unresolved why some of the individuals who develop IgG ab also develop IgE ab and become at risk for developing asthmatic responses. Only part of this risk is related to atopy. A striking feature of all the studies on animal allergy is the close association between IgE ab and asthma. It appears clear that it is those immune responses that include IgE ab that are a risk factor for asthma. It is not sensible for anyone to remain consistently sick with asthma and continue working with laboratory animals because there are well documented examples of occupational asthma that has not resolved after ceasing exposure.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W2013060770 created "2016-06-24" @default.
- W2013060770 creator A5013792144 @default.
- W2013060770 creator A5031783163 @default.
- W2013060770 creator A5060336976 @default.
- W2013060770 creator A5076890703 @default.
- W2013060770 date "1987-07-01" @default.
- W2013060770 modified "2023-09-25" @default.
- W2013060770 title "Asthma and Rhinitis Related to Laboratory Rats: Use of a Purified Rat Urinary Allergen to Study Exposure in Laboratories and the Human Immune Response" @default.
- W2013060770 doi "https://doi.org/10.2500/108854187779032451" @default.
- W2013060770 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3478580" @default.
- W2013060770 hasPublicationYear "1987" @default.
- W2013060770 type Work @default.
- W2013060770 sameAs 2013060770 @default.
- W2013060770 citedByCount "5" @default.
- W2013060770 countsByYear W20130607702013 @default.
- W2013060770 crossrefType "journal-article" @default.
- W2013060770 hasAuthorship W2013060770A5013792144 @default.
- W2013060770 hasAuthorship W2013060770A5031783163 @default.
- W2013060770 hasAuthorship W2013060770A5060336976 @default.
- W2013060770 hasAuthorship W2013060770A5076890703 @default.
- W2013060770 hasConcept C141105273 @default.
- W2013060770 hasConcept C159654299 @default.
- W2013060770 hasConcept C203014093 @default.
- W2013060770 hasConcept C207480886 @default.
- W2013060770 hasConcept C2776042228 @default.
- W2013060770 hasConcept C2777697326 @default.
- W2013060770 hasConcept C2778166374 @default.
- W2013060770 hasConcept C2779711295 @default.
- W2013060770 hasConcept C2780510475 @default.
- W2013060770 hasConcept C2909556404 @default.
- W2013060770 hasConcept C59822182 @default.
- W2013060770 hasConcept C71924100 @default.
- W2013060770 hasConcept C86803240 @default.
- W2013060770 hasConcept C8891405 @default.
- W2013060770 hasConceptScore W2013060770C141105273 @default.
- W2013060770 hasConceptScore W2013060770C159654299 @default.
- W2013060770 hasConceptScore W2013060770C203014093 @default.
- W2013060770 hasConceptScore W2013060770C207480886 @default.
- W2013060770 hasConceptScore W2013060770C2776042228 @default.
- W2013060770 hasConceptScore W2013060770C2777697326 @default.
- W2013060770 hasConceptScore W2013060770C2778166374 @default.
- W2013060770 hasConceptScore W2013060770C2779711295 @default.
- W2013060770 hasConceptScore W2013060770C2780510475 @default.
- W2013060770 hasConceptScore W2013060770C2909556404 @default.
- W2013060770 hasConceptScore W2013060770C59822182 @default.
- W2013060770 hasConceptScore W2013060770C71924100 @default.
- W2013060770 hasConceptScore W2013060770C86803240 @default.
- W2013060770 hasConceptScore W2013060770C8891405 @default.
- W2013060770 hasIssue "4" @default.
- W2013060770 hasLocation W20130607701 @default.
- W2013060770 hasLocation W20130607702 @default.
- W2013060770 hasOpenAccess W2013060770 @default.
- W2013060770 hasPrimaryLocation W20130607701 @default.
- W2013060770 hasRelatedWork W2013060770 @default.
- W2013060770 hasRelatedWork W2037019085 @default.
- W2013060770 hasRelatedWork W2064350188 @default.
- W2013060770 hasRelatedWork W2066867162 @default.
- W2013060770 hasRelatedWork W2083739516 @default.
- W2013060770 hasRelatedWork W2093685379 @default.
- W2013060770 hasRelatedWork W2112795145 @default.
- W2013060770 hasRelatedWork W2140517434 @default.
- W2013060770 hasRelatedWork W2266295269 @default.
- W2013060770 hasRelatedWork W2364142725 @default.
- W2013060770 hasVolume "8" @default.
- W2013060770 isParatext "false" @default.
- W2013060770 isRetracted "false" @default.
- W2013060770 magId "2013060770" @default.
- W2013060770 workType "article" @default.