FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013065360> ?p ?o ?g. }

• W2013065360 endingPage "32" @default.
• W2013065360 startingPage "21" @default.
• W2013065360 abstract "Protein-protein interactions (PPIs) can be useful targets for different pathologies. In fact controlling a function or attempting to repair an anomaly often means interfering with the cross-talk among different proteins. In order to have a general view of these cross-talks, Molecular Interaction Maps (MIMs) are used, organizing the enormous available information that is added every day and trying to understand the most suitable and accurate targets for any specific cell alteration. In this paper the c-Myc protein is taken as an example to explain the use of a map. The discovery of a peptidomimetic antagonist of c-Myc, active against proliferation of cancer cell lines, is reported and a possible mechanism of action is explained. To interfere with a specific protein-protein contact, a good starting point can be to consider a protein entity. Because the interaction between two proteins is normally characterized by a wide zone of contact, relative large inhibitors could be more convenient in the first approaches. Therefore, peptides mimicking the interacting zone can be considered as potential leads in the rational design of effective molecules. Here different examples of peptides as protein-protein interaction inhibitors are reported. Keywords: Protein-protein interactions (PPIs), molecular interaction maps (MIMs), peptides, c-Myc" @default.
• W2013065360 created "2016-06-24" @default.
• W2013065360 creator A5001846068 @default.
• W2013065360 creator A5021452591 @default.
• W2013065360 date "2007-01-01" @default.
• W2013065360 modified "2023-09-25" @default.
• W2013065360 title "Interfering with Protein-Protein Contact: Molecular Interaction Maps and Peptide Modulators" @default.
• W2013065360 cites W100165276 @default.
• W2013065360 cites W1512060784 @default.
• W2013065360 cites W1574601702 @default.
• W2013065360 cites W1600943063 @default.
• W2013065360 cites W1622668755 @default.
• W2013065360 cites W1953035097 @default.
• W2013065360 cites W1963503258 @default.
• W2013065360 cites W1964007399 @default.
• W2013065360 cites W1973095653 @default.
• W2013065360 cites W1989461823 @default.
• W2013065360 cites W1999994899 @default.
• W2013065360 cites W2001104186 @default.
• W2013065360 cites W2002404925 @default.
• W2013065360 cites W2012598468 @default.
• W2013065360 cites W2014735524 @default.
• W2013065360 cites W2023066846 @default.
• W2013065360 cites W2028828598 @default.
• W2013065360 cites W2029829614 @default.
• W2013065360 cites W2031913409 @default.
• W2013065360 cites W2033757712 @default.
• W2013065360 cites W2044312503 @default.
• W2013065360 cites W2046135441 @default.
• W2013065360 cites W2047632234 @default.
• W2013065360 cites W2050428831 @default.
• W2013065360 cites W2052949014 @default.
• W2013065360 cites W2057633014 @default.
• W2013065360 cites W2069441772 @default.
• W2013065360 cites W2069736057 @default.
• W2013065360 cites W2080731484 @default.
• W2013065360 cites W2081500012 @default.
• W2013065360 cites W2082867992 @default.
• W2013065360 cites W2093916491 @default.
• W2013065360 cites W2094905343 @default.
• W2013065360 cites W2096755059 @default.
• W2013065360 cites W2096946707 @default.
• W2013065360 cites W2097774235 @default.
• W2013065360 cites W2102612894 @default.
• W2013065360 cites W2106119346 @default.
• W2013065360 cites W2107769896 @default.
• W2013065360 cites W2112651905 @default.
• W2013065360 cites W2116622068 @default.
• W2013065360 cites W2121619780 @default.
• W2013065360 cites W2121963546 @default.
• W2013065360 cites W2122686086 @default.
• W2013065360 cites W2124254102 @default.
• W2013065360 cites W2125715557 @default.
• W2013065360 cites W2130594082 @default.
• W2013065360 cites W2130749378 @default.
• W2013065360 cites W2132911514 @default.
• W2013065360 cites W2136536867 @default.
• W2013065360 cites W2138024602 @default.
• W2013065360 cites W2138366746 @default.
• W2013065360 cites W2144015056 @default.
• W2013065360 cites W2144838583 @default.
• W2013065360 cites W2148128684 @default.
• W2013065360 cites W2149357952 @default.
• W2013065360 cites W2149517362 @default.
• W2013065360 cites W2149991291 @default.
• W2013065360 cites W2158110021 @default.
• W2013065360 cites W2160514373 @default.
• W2013065360 cites W2167150841 @default.
• W2013065360 cites W2170582708 @default.
• W2013065360 cites W2340606985 @default.
• W2013065360 doi "https://doi.org/10.2174/156802607779318271" @default.
• W2013065360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17266594" @default.
• W2013065360 hasPublicationYear "2007" @default.
• W2013065360 type Work @default.
• W2013065360 sameAs 2013065360 @default.
• W2013065360 citedByCount "12" @default.
• W2013065360 countsByYear W20130653602013 @default.
• W2013065360 countsByYear W20130653602016 @default.
• W2013065360 countsByYear W20130653602017 @default.
• W2013065360 crossrefType "journal-article" @default.
• W2013065360 hasAuthorship W2013065360A5001846068 @default.
• W2013065360 hasAuthorship W2013065360A5021452591 @default.
• W2013065360 hasConcept C11804247 @default.
• W2013065360 hasConcept C124790011 @default.
• W2013065360 hasConcept C12554922 @default.
• W2013065360 hasConcept C14036430 @default.
• W2013065360 hasConcept C161624437 @default.
• W2013065360 hasConcept C185592680 @default.
• W2013065360 hasConcept C2779281246 @default.
• W2013065360 hasConcept C41008148 @default.
• W2013065360 hasConcept C53105671 @default.
• W2013065360 hasConcept C54355233 @default.
• W2013065360 hasConcept C55493867 @default.
• W2013065360 hasConcept C70721500 @default.
• W2013065360 hasConcept C86803240 @default.
• W2013065360 hasConcept C95444343 @default.
• W2013065360 hasConceptScore W2013065360C11804247 @default.
• W2013065360 hasConceptScore W2013065360C124790011 @default.

• next