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- W2013065467 abstract "In adult neutropenic patients with hematological malignancies, we explored imipenem-cilastatin as empirical antibiotic therapy in a dose of 500 mg four times daily. Changing to second-line treatment was only resorted to if clinical deterioration, new infections or recurrence of fever occurred. A clinically or microbiologically documented infection was apparent in 115 of 150 episodes studied (76.7%). Imipenem-cilastatin was successful in 70.7% of all episodes and in 67.8% of all proven infections. Modification was necessary and successful in 22.0% of all episodes. 11 patients died while still febrile, 6 of them by infection (4%) and 5 because of progressive disease (3.3%). Imipenem-cilastatin is safe initial therapy in neutropenic febrile patients." @default.
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- W2013065467 date "2009-04-24" @default.
- W2013065467 modified "2023-09-27" @default.
- W2013065467 title "Imipenem-cilastatin for empirical therapy in neutropenic patients with fever: An open study in patients with hematologic malignancies" @default.
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- W2013065467 doi "https://doi.org/10.1111/j.1600-0609.1991.tb00512.x" @default.
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