FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013072008> ?p ?o ?g. }

• W2013072008 endingPage "579" @default.
• W2013072008 startingPage "573" @default.
• W2013072008 abstract "We investigated the prognostic significance of p53-gene mutation (exon 5-9) and bcl-2-protein expression in primary squamous-cell carcinoma of the head and neck (HNSCC) treated by curative radiotherapy (RT). Primary squamous-cell carcinomas for analysis were obtained from 85 consecutive head-and-neck-cancer patients, with complete follow-up data. We detected bcl-2 protein in 24% (20/85) of HNSCC studied; 38 (45%) of the 85 tumours had cells bearing p53 mutations. A strong association was observed between tobacco exposure and bcl-2-protein expression (p = 0.003), an association also evident in those patients who had a p53-mutated carcinoma (p = 0.049). Moreover, we found that most of the bcl-2-positive cancers (70%) were also mutated in the p53 gene (p = 0.010). In univariate and in multivariate analyses, the simultaneous detection of bcl-2 expression and a p53-gene mutation in a tumour biopsy specimen was associated with greater risk of locoregional failure (p = 0.002 and 0.001 respectively) and worse survival (p = 0. 045 and 0.033) within 5 years in HNSCC patients treated by RT. The present study shows a cumulative prognostic value of simultaneous detection of bcl-2 over-expression and p53-gene aberration in some primary HNSCC treated with conventional RT, and provides further evidence for cross-talk between p53 and bcl-2, suggesting that these genes are important determinants of radiation-induced apoptosis, thereby modulating resistance to RT. Int. J. Cancer (Pred. Oncol.) 84:573-579, 1999." @default.
• W2013072008 created "2016-06-24" @default.
• W2013072008 creator A5014687372 @default.
• W2013072008 creator A5014840243 @default.
• W2013072008 creator A5037827357 @default.
• W2013072008 creator A5037951906 @default.
• W2013072008 creator A5068619119 @default.
• W2013072008 creator A5073950636 @default.
• W2013072008 date "1999-12-22" @default.
• W2013072008 modified "2023-10-18" @default.
• W2013072008 title "Cumulative prognostic value ofp53 mutations and bcl-2 protein expression in head-and-neck cancer treated by radiotherapy" @default.
• W2013072008 cites W1979319210 @default.
• W2013072008 cites W1982580354 @default.
• W2013072008 cites W1991915284 @default.
• W2013072008 cites W2008790847 @default.
• W2013072008 cites W2028027936 @default.
• W2013072008 cites W2030283142 @default.
• W2013072008 cites W2030362566 @default.
• W2013072008 cites W2032361307 @default.
• W2013072008 cites W2043066069 @default.
• W2013072008 cites W2051774899 @default.
• W2013072008 cites W2055078984 @default.
• W2013072008 cites W2058591356 @default.
• W2013072008 cites W2075696892 @default.
• W2013072008 cites W2078581194 @default.
• W2013072008 cites W2082030057 @default.
• W2013072008 cites W2094863625 @default.
• W2013072008 cites W2112894340 @default.
• W2013072008 cites W2123754647 @default.
• W2013072008 cites W2144322780 @default.
• W2013072008 cites W2312732552 @default.
• W2013072008 cites W2316316905 @default.
• W2013072008 cites W2317541954 @default.
• W2013072008 cites W2318089032 @default.
• W2013072008 cites W4293241248 @default.
• W2013072008 doi "https://doi.org/10.1002/(sici)1097-0215(19991222)84:6<573::aid-ijc6>3.0.co;2-r" @default.
• W2013072008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10567901" @default.
• W2013072008 hasPublicationYear "1999" @default.
• W2013072008 type Work @default.
• W2013072008 sameAs 2013072008 @default.
• W2013072008 citedByCount "68" @default.
• W2013072008 countsByYear W20130720082012 @default.
• W2013072008 countsByYear W20130720082013 @default.
• W2013072008 countsByYear W20130720082014 @default.
• W2013072008 countsByYear W20130720082015 @default.
• W2013072008 countsByYear W20130720082016 @default.
• W2013072008 countsByYear W20130720082021 @default.
• W2013072008 countsByYear W20130720082023 @default.
• W2013072008 crossrefType "journal-article" @default.
• W2013072008 hasAuthorship W2013072008A5014687372 @default.
• W2013072008 hasAuthorship W2013072008A5014840243 @default.
• W2013072008 hasAuthorship W2013072008A5037827357 @default.
• W2013072008 hasAuthorship W2013072008A5037951906 @default.
• W2013072008 hasAuthorship W2013072008A5068619119 @default.
• W2013072008 hasAuthorship W2013072008A5073950636 @default.
• W2013072008 hasBestOaLocation W20130720081 @default.
• W2013072008 hasConcept C104317684 @default.
• W2013072008 hasConcept C121608353 @default.
• W2013072008 hasConcept C126322002 @default.
• W2013072008 hasConcept C142724271 @default.
• W2013072008 hasConcept C143998085 @default.
• W2013072008 hasConcept C144301174 @default.
• W2013072008 hasConcept C2776530083 @default.
• W2013072008 hasConcept C2776833033 @default.
• W2013072008 hasConcept C2777546739 @default.
• W2013072008 hasConcept C2994225774 @default.
• W2013072008 hasConcept C38180746 @default.
• W2013072008 hasConcept C501734568 @default.
• W2013072008 hasConcept C502942594 @default.
• W2013072008 hasConcept C509974204 @default.
• W2013072008 hasConcept C54355233 @default.
• W2013072008 hasConcept C71924100 @default.
• W2013072008 hasConcept C86803240 @default.
• W2013072008 hasConceptScore W2013072008C104317684 @default.
• W2013072008 hasConceptScore W2013072008C121608353 @default.
• W2013072008 hasConceptScore W2013072008C126322002 @default.
• W2013072008 hasConceptScore W2013072008C142724271 @default.
• W2013072008 hasConceptScore W2013072008C143998085 @default.
• W2013072008 hasConceptScore W2013072008C144301174 @default.
• W2013072008 hasConceptScore W2013072008C2776530083 @default.
• W2013072008 hasConceptScore W2013072008C2776833033 @default.
• W2013072008 hasConceptScore W2013072008C2777546739 @default.
• W2013072008 hasConceptScore W2013072008C2994225774 @default.
• W2013072008 hasConceptScore W2013072008C38180746 @default.
• W2013072008 hasConceptScore W2013072008C501734568 @default.
• W2013072008 hasConceptScore W2013072008C502942594 @default.
• W2013072008 hasConceptScore W2013072008C509974204 @default.
• W2013072008 hasConceptScore W2013072008C54355233 @default.
• W2013072008 hasConceptScore W2013072008C71924100 @default.
• W2013072008 hasConceptScore W2013072008C86803240 @default.
• W2013072008 hasIssue "6" @default.
• W2013072008 hasLocation W20130720081 @default.
• W2013072008 hasLocation W20130720082 @default.
• W2013072008 hasOpenAccess W2013072008 @default.
• W2013072008 hasPrimaryLocation W20130720081 @default.
• W2013072008 hasRelatedWork W1996158748 @default.
• W2013072008 hasRelatedWork W2086793060 @default.
• W2013072008 hasRelatedWork W2382362179 @default.

• next