Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013073357> ?p ?o ?g. }
- W2013073357 endingPage "10224" @default.
- W2013073357 startingPage "10219" @default.
- W2013073357 abstract "Metabotropic glutamate receptors (mGluRs) are responsible for the effects of glutamate in slow synaptic transmission, and are implicated in the regulation of many processes in the CNS. Recently, we have reported the expression and purification of a mGluR from Drosophila melanogaster (DmGluRA), a homologue of mammalian group II mGluRs. We have shown that ligand binding to reconstituted DmGluRA requires the presence of ergosterol in the liposomes [Eroglu, C., Cronet, P., Panneels, V., Beaufils, P. & Sinning, I. (2002) EMBO Rep. 3, 491-496]. Here we demonstrate that the receptor exists in different affinity states for glutamate, depending on the membrane composition. The receptor is in a high-affinity state when associated with sterol-rich lipid microdomains (rafts), and in a low-affinity state out of rafts. Enrichment of the membranes with cholesterol shifts the receptor into the high-affinity state, and induces its association with rafts. The receptor was crosslinked to photocholesterol. Our data suggest that sterol-rich lipid rafts act as positive allosteric regulators of DmGluRA." @default.
- W2013073357 created "2016-06-24" @default.
- W2013073357 creator A5010096628 @default.
- W2013073357 creator A5017962710 @default.
- W2013073357 creator A5018451838 @default.
- W2013073357 creator A5060010220 @default.
- W2013073357 date "2003-08-15" @default.
- W2013073357 modified "2023-10-13" @default.
- W2013073357 title "Glutamate-binding affinity of <i>Drosophila</i> metabotropic glutamate receptor is modulated by association with lipid rafts" @default.
- W2013073357 cites W1538172306 @default.
- W2013073357 cites W1552569483 @default.
- W2013073357 cites W1557764831 @default.
- W2013073357 cites W1564861448 @default.
- W2013073357 cites W1566497779 @default.
- W2013073357 cites W1571978724 @default.
- W2013073357 cites W1576507987 @default.
- W2013073357 cites W1599164179 @default.
- W2013073357 cites W1767524333 @default.
- W2013073357 cites W1945680072 @default.
- W2013073357 cites W1956143364 @default.
- W2013073357 cites W1964310407 @default.
- W2013073357 cites W1964598018 @default.
- W2013073357 cites W1967200327 @default.
- W2013073357 cites W1968483045 @default.
- W2013073357 cites W1975325447 @default.
- W2013073357 cites W1978139101 @default.
- W2013073357 cites W1978846511 @default.
- W2013073357 cites W1987506105 @default.
- W2013073357 cites W1987898211 @default.
- W2013073357 cites W1993629125 @default.
- W2013073357 cites W1996988785 @default.
- W2013073357 cites W2005690045 @default.
- W2013073357 cites W2008981610 @default.
- W2013073357 cites W2009230396 @default.
- W2013073357 cites W2011626152 @default.
- W2013073357 cites W2019497539 @default.
- W2013073357 cites W2023247734 @default.
- W2013073357 cites W2023286308 @default.
- W2013073357 cites W2024474477 @default.
- W2013073357 cites W2032967866 @default.
- W2013073357 cites W2037735248 @default.
- W2013073357 cites W2045765706 @default.
- W2013073357 cites W2049848440 @default.
- W2013073357 cites W2063226099 @default.
- W2013073357 cites W2064284529 @default.
- W2013073357 cites W2072274588 @default.
- W2013073357 cites W2074310540 @default.
- W2013073357 cites W2077202970 @default.
- W2013073357 cites W2077727777 @default.
- W2013073357 cites W2086358590 @default.
- W2013073357 cites W2092296126 @default.
- W2013073357 cites W2106042714 @default.
- W2013073357 cites W2110022036 @default.
- W2013073357 cites W2112194608 @default.
- W2013073357 cites W2121936687 @default.
- W2013073357 cites W2134539481 @default.
- W2013073357 cites W2138059603 @default.
- W2013073357 cites W2148674149 @default.
- W2013073357 cites W2152311269 @default.
- W2013073357 cites W2156034154 @default.
- W2013073357 cites W2161281789 @default.
- W2013073357 cites W2185275183 @default.
- W2013073357 cites W2289623110 @default.
- W2013073357 cites W2300552860 @default.
- W2013073357 cites W4321428222 @default.
- W2013073357 doi "https://doi.org/10.1073/pnas.1737042100" @default.
- W2013073357 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/193542" @default.
- W2013073357 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12923296" @default.
- W2013073357 hasPublicationYear "2003" @default.
- W2013073357 type Work @default.
- W2013073357 sameAs 2013073357 @default.
- W2013073357 citedByCount "94" @default.
- W2013073357 countsByYear W20130733572012 @default.
- W2013073357 countsByYear W20130733572013 @default.
- W2013073357 countsByYear W20130733572014 @default.
- W2013073357 countsByYear W20130733572015 @default.
- W2013073357 countsByYear W20130733572017 @default.
- W2013073357 countsByYear W20130733572018 @default.
- W2013073357 countsByYear W20130733572019 @default.
- W2013073357 countsByYear W20130733572020 @default.
- W2013073357 countsByYear W20130733572022 @default.
- W2013073357 countsByYear W20130733572023 @default.
- W2013073357 crossrefType "journal-article" @default.
- W2013073357 hasAuthorship W2013073357A5010096628 @default.
- W2013073357 hasAuthorship W2013073357A5017962710 @default.
- W2013073357 hasAuthorship W2013073357A5018451838 @default.
- W2013073357 hasAuthorship W2013073357A5060010220 @default.
- W2013073357 hasBestOaLocation W20130733572 @default.
- W2013073357 hasConcept C116592611 @default.
- W2013073357 hasConcept C119128870 @default.
- W2013073357 hasConcept C170493617 @default.
- W2013073357 hasConcept C185592680 @default.
- W2013073357 hasConcept C200385062 @default.
- W2013073357 hasConcept C207951395 @default.
- W2013073357 hasConcept C49051014 @default.
- W2013073357 hasConcept C55493867 @default.
- W2013073357 hasConcept C56940625 @default.
- W2013073357 hasConcept C61174792 @default.